Investigation of the treatment modality in primary lymphoma of the salivary glands.

PURPOSE: To review our experience in managing primary lymphoma of the major salivary glands by analysing the treatment modality of patients. METHODS: In this study, we reviewed the medical records of 26 patients with primary malignant lymphoma of the major salivary glands who were treated at Beijing Stomatological Hospital of Capital Medical University from January 1999 to March 2015. The predictor variable was treatment modality. The outcome variables were overall survival (OS), disease-free survival (DFS), disease-special survival (DSS) and local control (LC). Other relevant variables were as follows: age, sex, pathological pattern, tumour site, clinical features, source, IPI and Ann-Arbor stage. The data were analysed by the χ2 test, log-rank test, and univariate analysis. RESULTS: Of the 26 patients, 14 received surgery only, four received initial surgery combined with adjuvant radiotherapy, five received adjuvant chemotherapy, and three received adjuvant radiochemotherapy. During the median follow-up period of 104 months, the overall estimates of OS, DFS, DSS and LC were 84.6, 84.6, 88.5 and 92.3%, respectively. Good outcomes were achieved in patients who received surgery combined with postoperative RT, followed by surgery only. MALT lymphoma had a better prognosis than the other pathological patterns. Mass, swelling, pathological pattern and Ann-Arbor stage were important prognostic factors. CONCLUSION: Surgery combined with postoperative radiotherapy may be an appropriate choice for patients with MALT lymphoma. The pathological pattern, mass, swelling and Ann-Arbor stage were associated with an unfavourable prognosis.

Prognostic value of pathologic grade for patients with oral squamous cell carcinoma.

OBJECTIVE: The purposes of this study were to explore both the prognostic value of pathologic grade and the relationships between differentiation and clinicopathological characteristics in oral squamous cell carcinoma. METHODS: This retrospective cohort study included the records of 2036 patients with oral squamous cell carcinoma who were surgically treated from June 1999 to December 2011. Chi-square test, Kaplan-Meier analysis, and Cox proportional hazards regression model were performed for statistical analysis. RESULTS: Many clinicopathological characteristics were associated with pathologic grade. Kaplan-Meier analysis showed that well-differentiated tumors had a better prognosis than the other two grades. Cox regression model showed that differentiation was an independent risk factor for prognosis in patients with early stage, but not with advanced stage. The predictive abilities of pathologic grade, T stage, N status, and lymph node ratio were similar, but the presence of extracapsular spread and perineural invasion were stronger prognostic factors than pathologic differentiation. CONCLUSIONS: Pathologic grade was found to be an independent risk factor for early-stage oral squamous cell carcinoma, but not for advanced stage. Many important clinicopathological characteristics were associated with histological classification; however, its prognostic value was limited.

[Changes in the binding characteristics of central kappa-opioid receptor during the development of 100 Hz electroacupuncture (EA) tolerance in rats].

The effect of repetitive 100 Hz EA stimulation on the characteristics of binding of kappa opioid receptors in discrete brain regions and the spinal cord of rats was investigated by radioligand binding assay. 100 Hz EA was administered once a day (30 min) for 7 d. Changes in Bmax and Kd of kappa opioid receptors of 4 discrete brain regions (cortex, midbrain, pons-medulla and striatum) and spinal cord were observed at d 1, 3, 5 and 7, respectively. It was found that the numbers (Bmax) of kappa opioid receptors of all the brain regions observed were decreased during the development of 100 Hz EA tolerance with a differential time course. In rat cortex and pons-medulla, a marked down regulation of kappa opioid receptors occurred within 24 h and remained at a low level throughout the observation. The Bmax of kappa receptor in spinal cord showed a bell-shaped curve, i.e., up regulation in the first 5 days and down regulation at d 7. In contrast a slow and steady down regulation was found in the midbrain and striatum, matching the course of development of 100 Hz EA tolerance. No significant changes in Kd of [3H]-U69593 were found except for a decrease of Kd in midbrain. In conclusion, administration of 100 Hz EA 30 min per day for 7 consecutive days resulted in a significant down regulation of kappa opioid receptor in CNS, especially in midbrain and striatum.