RESUMO
As a widely used brain-computer interface (BCI) paradigm, steady-state visually evoked potential (SSVEP)-based BCIs have the advantages of high information transfer rates, high tolerance for artifacts, and robust performance across diverse users. However, the incidence of mental fatigue from prolonged, repetitive stimulation is a critical issue for SSVEP-based BCIs. Music is often used as a convenient, non-invasive means of relieving mental fatigue. This study investigates the compensatory effect of music on mental fatigue through the introduction of different modes of background music in long-duration, SSVEP-BCI tasks. Changes in electroencephalography power index, SSVEP amplitude, and signal-to-noise ratio were used to assess participants' mental fatigue. The study's results show that the introduction of exciting background music to the SSVEP-BCI task was effective in relieving participants' mental fatigue. In addition, for continuous SSVEP-BCI tasks, a combination of musical modes that used soothing background music during the rest interval phase proved more effective in reducing users' mental fatigue. This suggests that background music can provide a practical solution for long-duration SSVEP-based BCI implementation.
RESUMO
Hybrid brain-computer interface (hBCI) refers to a system composed of a single-modality BCI and another system. In this paper, we propose an online hybrid BCI combining steady-state visual evoked potential (SSVEP) and eye movements to improve the performance of BCI systems. Twenty buttons corresponding to 20 characters are evenly distributed in the five regions of the GUI and flash at the same time to arouse SSVEP. At the end of the flash, the buttons in the four regions move in different directions, and the subject continues to stare at the target with eyes to generate the corresponding eye movements. The CCA method and FBCCA method were used to detect SSVEP, and the electrooculography (EOG) waveform was used to detect eye movements. Based on the EOG features, this paper proposes a decision-making method based on SSVEP and EOG, which can further improve the performance of the hybrid BCI system. Ten healthy students took part in our experiment, and the average accuracy and information transfer rate of the system were 94.75% and 108.63 bits/min, respectively.
RESUMO
Androgen receptor (AR) is an effective therapeutic target for the treatment of prostate cancer. We report herein the design, synthesis, and biological evaluation of highly effective proteolysis targeting chimeras (PROTAC) androgen receptor (AR) degraders, such as compound A031. It could induce the degradation of AR protein in VCaP cell lines in a time-dependent manner, achieving the IC 50 value of less than 0.25 µM. The A031 is 5 times less toxic than EZLA and works with an appropriate half-life (t 1/2) or clearance rate (Cl). Also, it has a significant inhibitory effect on tumor growth in zebrafish transplanted with human prostate cancer (VCaP). Therefore, A031 provides a further idea of developing novel drugs for prostate cancer.
