[The intrauterine active disposition in the dysfunctional uterine bleeding: its action on miometrium, endometrium and vaginal epithelium]. / El dispositivo intrauterino active en los sangrados uterinos disfuncionales: su efecto sobre miometrio, endometrio y epitelio vaginal.

PIP: 30 patients, most of them with dysfunctional uterine bleeding, were inserted with Progestasert, a T-shaped IUD, releasing 65 mcg. of progesterone daily. All patients were carefully examined before and after insertion. In 90% of cases bleeding decreased in amount and in duration; there were 2 cases of amenorrhea. Endometrial action was characterized by secretory changes, decidual reaction, and desquamation of glandular structure. Vaginal cytology was not sensibly modified, while uterine contractility and uterine tonus were increased, particularly during the second phase of the menstrual cycle. It is obvious that progesterone has a definite in situ effect but no collateral systemic action, which makes it indicated in the treatment of dysfunctional uterine bleeding.^ieng

Fertility following termination of the once-a-month oral contraceptive.

PIP: The rate of fertility return as evidenced by conception after discontinuance, endometrial biopsies and return to menstruation was evaluated in 290 women who used the oral contraceptive quinestrol and quingestanol acetate once a month. 73% had their first menstrual flow 25-45 days after the last drug induced bleeding with a significant direct relationship of minimal influence between the duration of therapy and the time interval to menstruation. 104 of 111 women who desired a pregnancy conceived in an average of 7 months after their last treatment. There was no significant relationship between the duration of treatment, time to conceive or the autrome of the therapy. 72% of the 152 biopsies taken 14 days or less before the first regular menstruation showed a normal secretory endothelium with no correlation to duration of therapy.^ieng

[Use of the system of progesterone liberation in uterol in dysfunctional uterine bleeding]. / Uso del sistema de liberación de progesterona in utero en sangrados uterinos disfuncionales

PIP: 10 patients, aged 25-46, with dysfunctional menstrual bleeding, were inserted a progesterone-releasing IUD, delivering 65 mcg. of progesterone daily. Complete examinations were carried out before insertion, and after 3 and 6 months. Amount and duration of bleeding diminished in 9 patients; 2 patients presented short periods of amenorrhea. Proliferative endometria changed in secreting endometria, while vaginal cytology with previous estrogenic activity did not change in 2 cases, or insufficiently in 2 more cases. From these results it is concluded that progesterone has a local action at endometrial level, but no systemic collateral actions, and that it can be usefully employed in controlling dysfunctional bleeding.^ieng