Clinical and Microbiological Aspects of Chronic Endometritis in Women of Reproductive Age.

OBJECTIVE: Estimation of microbiocenosis of lower and upper genital tract in different morphological forms of chronic endometritis and endometrial polyps. MATERIAL AND METHODS: Histological examination of endometrial aspirates and microview of the lower and upper genital tract in 164 women of reproductive age with different character of menstrual and reproductive history. RESULTS: The risk of endometrial colonization in, disturbance microecology of the vagina is 3.5 times higher than that, in patients with normosenosis (p<0.01, OP=3.5 [95%. CI 1.63-8.11]). CONCLUSION: The microbiological diagnosis can be considered as a component of comprehensive diagnostics necessary to choose the appropriate management of patients with CE and PE.

[A comparison of the results of analyzing the clinical data from gynecological, ophthalmological and dental patients using a set of rapid methods for the diagnosis of herpesvirus infection]. / Sopostavlenie rezul'tatov analiza klinicheskikh materialov ginekologicheskogo, oftal'mologicheskogo i stomatologicheskogo profilei naborom ékspress-metodov diagnostiki gerpesvirusnoi infektsii.

Analysis of biological specimens from gynecological, ophthalmological, and stomatological patients was carried out using current express methods for diagnosis of herpes virus infection developed by the authors: enzyme immunoassay (EIA), time-resolved fluoroimmunoassay (tr-FIA), molecular hybridization and conventional immunofluorescence technique. Monoclonal antibodies (MCA) generated by us with epitope specificity for gpD HSV-2 were used in EIA and tr-FIA. F(ab')2-fragments of MCA used as sorbents and for preparation of conjugates were found to be by 250% more sensitive than intact IgG used for similar purposes. The employment of EIA based on MCA F(ab')2-fragments contributed to detection of 0.2-0.6 ng of virus-specific protein in a specimen. Comparison of the results of analysis of clinical specimens of broad spectrum (mucous secreta from the cervical canal of the uterus and posterior vault of the vagina, saliva, lacrimal fluid) by the above express methods for diagnosis of herpes virus infection revealed a high percentage of positive findings, none of the methods providing 100% diagnosis. The use of a set of methods makes the resultant information more objective. Therefore, in future the data obtained by a number of current express methods for herpes diagnosis should be compared.

[Laparoscopic picture in patients with oligomenorrhea treated for chronic salpingo-oophoritis]. / Laparoskopicheskaia kartina u bo'lnykh s oligomenoreei, lechivshikhsia po povodu khronicheskogo sa'lpingooforita.

Sixty patients with oligomenorrhea and the painful syndrome were examined to study the course of a chronic inflammatory process of the genitals. Laparoscopy has confirmed the initial diagnosis of salpingo-oophoritis in 24 of the 60 examinees. The authors call for a more thorough examination of this patient population, for an erroneous diagnosis of a chronic inflammation leads to erroneous therapeutic strategy, consisting in irrational administration of antibacterial, balneo- and physiotherapy.

[Platelet aggregation during the intake of sex steroids in patients with dysfunctional uterine hemorrhages in the climacteric]. / Agregatsiia trombotsitov pri primenenii polovykh steroidov u bol'nykh s disfunktsional'nymi matochnymi krovotecheniiami v klimaktericheskom periode.

PIP: Platelet aggregation during steroidal treatment of dysfunctional uterine hemorrhages in the climacteric was studied. Non-ovlon, containing .05 mg of ethinyl estradiol and 1 mg of norethisterone acetate, and Norcolut, containing 5 mg of norethisterone, were used as sex steroids. The study included 60 women, aged 40-53 years, with dysfunctional hemorrhages. The control group consisted of 20 healthy women in the same age group. Upon admission, all patients were complaining of uterine hemorrhages and general weakness. In most cases, the hemorrhages were of an acyclical nature. In 3 months, 5 of the 20 women taking Non-ovlon developed the clinical symptoms of thrombophilia. In 3 of the 5 patients, symptoms of thrombophlebitis were observed. Hormonal therapy for these patients was terminated and they were treated with anticoagulants and antiaggregants. Norcolut caused no clinical symptons of thrombophilia. Results were confirmed by platelet determinations and aggregatograms. Comparison of clinical and laboratory data suggests a direct correlation between platelet hyperactivity and the genesis of the aforementioned complications of combined estrogen/gestagen preparations. Results contribute to a better understanding of the disorders occurring during the intake of sex steroids in the climacteric.^ieng