Simple implantable wireless sensor platform to measure pressure and force.

Smart implants have the potential to enable personalized care regimens for patients. However, the integration of smart implants into daily clinical practice is limited by the size and cost of available sensing technology. Passive resonant sensors are an attractive alternative to traditional sensing technologies because they obviate the need for on-sensor signal conditioning or telemetry and are substantially simpler, smaller, less expensive, and more robust than other sensing methods. We have developed a novel simple, passive sensing platform that is adaptable to a variety of applications. Sensors consist of only two disconnected parallel Archimedean spiral coils and an intervening solid dielectric layer. When exposed to force or pressure, the resonant frequency of the circuit shifts which can be measured wirelessly. We fabricated prototype pressure sensors and force sensors and compared their performance to a lumped parameter model which predicts sensor behavior. The sensors exhibited a linear response (R2 > 0.91) to dynamic changes in pressure or force with excellent sensitivity. Experimental data were within 13.3% and 6.2% of the values predicted by the model for force and pressure respectively. Results demonstrate that the sensors can be adapted to measure various measurands through a span of sensitivities and ranges by appropriate selection of the intervening layer.

Reducing the effect of parasitic capacitance on implantable passive resonant sensors.

Passive, LC resonators have the potential to serve as small, robust, low cost, implantable sensors to wirelessly monitor implants following orthopedic surgery. One significant barrier to using LC sensors is the influence on the sensor's resonance of the surrounding conductive high permittivity media in vivo. The surrounding media can detune the resonant frequency of the LC sensor resulting in a bias. To mitigate the effects of the surrounding media, we added a "capping layer" to LC sensors to isolate them from the surrounding media. Several capping materials and thicknesses were tested to determine effectiveness at reducing the sensor's interaction with the surrounding media. Results show that a 1 mm glass capping layer on the outer surfaces of the sensor was sufficient to reduce the effects of the media on sensor signal to less than 1%.

Picosecond optical thermometry of protein in H2O.

We demonstrate the use of transient IR absorption measurements for picosecond thermometry of protein in an aqueous environment. For small temperature changes, measured transient absorption changes are shown to be in excellent agreement with the "static" temperature dependence of the protein and water constituents of the sample as measured by FTIR spectroscopy. The thermally induced changes in IR absorption reach equilibrium within a few picoseconds, making this technique an excellent tool for picosecond thermometry.

Cavity ringdown spectroscopy of thin films in the mid-infrared.

To demonstrate the potential of the cavity ringdown technique in mid-infrared spectroscopy of thin film samples, we measured absorption losses in a C60 film on a BaF2 substrate using a tunable optical parametric amplifier source. With a Brewster angle sample geometry, we achieved a fractional loss sensitivity as small as 1.3 x 10(-7) with 1.5 cm(-1) resolution, an improvement in sensitivity of 2 orders of magnitude compared to standard Fourier transform infrared methods. At an absorption sensitivity of 5 x 10(-7), spectra of several C60 overtone lines were recorded.