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PLoS One ; 19(6): e0305469, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38889116

RESUMO

Diarrheal diseases are important causes of morbidity and mortality, worldwide. The occurrence of multiple pathogens in stool samples of symptomatic and asymptomatic individuals in resource-limited countries have been repeatedly described. In this study, we assessed the differentiated effects of combined pathogen detections on recorded symptoms. A case-control study was conducted among 620 under-five-year-old children in rural northeastern Tanzania with emphasis of multiple detection. The median age of children was 11 months (IQR = 7, 20), and 52.1% were male. Cases (50.2%, n = 157) were less likely than controls (64.5%, n = 198) to have multiple colonization with gastrointestinal tract (GIT) pathogens. The children's age was positively associated with the likelihood of harboring multiple GIT pathogens [OR, 1.02, 95% CI = 1.01, 1.04]. Shigella spp./enteroinvasive Escherichia coli (EIEC) [OR = 2.80, 95% CI 1.62, 4.83] and norovirus [OR = 2.04, 95% CI 1.23, 3.39] were more common in cases and were strongly associated with diarrhea, while enteroaggregative E. coli (EAEC) [OR = 0.23, 95%CI 0.17-0.33] were more common in controls. Diarrheal diseases in under-five children from rural Tanzania are likely to be due to infections with Shigella spp./EIEC, and norovirus with strongly age-dependent associations.


Assuntos
Diarreia , População Rural , Humanos , Tanzânia/epidemiologia , Masculino , Feminino , Estudos de Casos e Controles , Diarreia/epidemiologia , Diarreia/microbiologia , Lactente , Pré-Escolar , População Rural/estatística & dados numéricos , Shigella/isolamento & purificação , Fezes/microbiologia , Trato Gastrointestinal/microbiologia , Norovirus/isolamento & purificação , Escherichia coli/isolamento & purificação
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