[Technological problems in use of fast reactors for radiotherapy of patients with malignant tumors]. / Tekhnologicheskie problemy ispol'zovaniia issledovatel'skikh reaktorov na bystrykh neítronakh dlia luchevoí terapii bol'nykh zlokachestvennymi opukholiami.

The authors discuss the technological problems associated with the use of fast neutrons in radiotherapy of cancer patients and outline the approaches to the solution of these problems. The state of the art is assessed. Physical and radiobiological prerequisites for the use of fast reactors for radiotherapy of patients with malignant tumors are analyzed. Results of clinical use of BR-10 reactor at the Medical Radiology Research Center, Russian Academy of Medical Sciences, are presented. Experimental and clinical findings indicate that the results of radiotherapy may be appreciably improved if a novel perspective source of fast neutrons, a nuclear reactor, is used.

[Combined therapy of malignant tumors of the upper jaw and nasal cavity using pre- and post-operative radiation with metronidazol radiomodification]. / Kombinirovannye lechenie zlokachestvennykh opukholei verkhnei cheliusti i polosti nosa s ispol'zovaniem pred- i posleoperatsionnogo kyrsov oblucheniia v sochetanii s radiomodifikatsiei metronidazolom.

Seventy-five patients with malignant tumors of the upper jaw and nasal cavity have received combination therapy. Administration of metronidasol (5-8 g/m2 body surface) in combination with large doses of preoperative radiation was shown to significantly improve 3-year total and recurrence-free survival-from 50 to 60% and 32 to 57%, respectively. As a result, no postoperative radiotherapy was required. Postoperative radiation treatment is indicated when means of radiosensibilization are not used. The use of radiomodifiers is mandatory in combination therapy of non-differentiated cell carcinoma, cylindroma, transitory-cell papilloma and non-epithelial neoplasms.