RESUMO
El tratamiento del brote grave de colitis ulcerosa sigue siendo un reto para el gastroenterológo clínico. Un porcentaje no despreciable de pacientes presentará a lo largo de su vida un brote grave de colitis ulcerosa que precisará de un ingreso hospitalario. La mortalidad en los brotes graves de colitis ulcerosa sigue siendo elevada por lo que el tratamiento de este debe ser agresivo, evitando demoras en la realización de una terapia de rescate o incluso de la indicación de cirugía. El objetivo de esta revisión es describir el tratamiento médico del brote grave de colitis ulcerosa destacando los últimos avances terapéuticos
The treatment of severe ulcerative colitis remains a challenge for gastroenterologists. A not inconsiderable number of patients will experience severeflares throughout their lives and will require hospitalization. Mortality in severe ulcerative colitis is still high and consequently treatment must be aggressive, avoiding delays in rescue therapies or even surgery. The aim of this review was to describe the medical treatment of severe ulcerative colitis, highlighting recent therapeutic advances
Assuntos
Humanos , Colite Ulcerativa/tratamento farmacológico , Ciclosporina/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Tratamento de Emergência/métodos , Recidiva , Índice de Gravidade de Doença , Remoção de Componentes Sanguíneos , Calcineurina/antagonistas & inibidoresRESUMO
The treatment of severe ulcerative colitis remains a challenge for gastroenterologists. A not inconsiderable number of patients will experience severe flares throughout their lives and will require hospitalization. Mortality in severe ulcerative colitis is still high and consequently treatment must be aggressive, avoiding delays in rescue therapies or even surgery. The aim of this review was to describe the medical treatment of severe ulcerative colitis, highlighting recent therapeutic advances.
