1.
Bioorg Med Chem Lett
; 19(18): 5321-4, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19692239
RESUMO
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-13 inhibitors. Potency and selectivity were improved by extending the hit structure out from the active site into the S1' pocket.