Three contextual dimensions of information on social media: lessons learned from the COVID-19 infodemic.

The COVID-19 pandemic has been accompanied on social media by an explosion of information disorders such as inaccurate, misleading and irrelevant information. Countermeasures adopted thus far to curb these informational disorders have had limited success because these did not account for the diversity of informational contexts on social media, focusing instead almost exclusively on curating the factual content of user's posts. However, content-focused measures do not address the primary causes of the infodemic itself, namely the user's need to post content as a way of making sense of the situation and for gathering reactions of consensus from friends. This paper describes three types of informational context-weak epistemic, strong normative and strong emotional-which have not yet been taken into account by current measures to curb down the informational disorders. I show how these contexts are related to the infodemic and I propose measures for dealing with them for future global crisis situations.

Clinical and Pathogenic Correlations Between SARS-CoV-2 Infection and Hemolytic Uremic Syndrome in Children.

Background The present paper examines the correlations between coronavirus disease (COVID-19) and hemolytic uremic syndrome (HUS) from a clinical and pathophysiological point of view. Method: We describe COVID-19 and HUS by outlining the similarities and differences, detailing each one's pathway into the body, explaining the consequences of the inflammatory response, mainly on multiple organ dysfunction, the foremost complication that can lead to death in both cases. Using reviews from specialized literature and guidelines, we had an approach based on critical interpretive synthesis. Nonetheless, the present article has certain limitations, mainly due to the short period from the emergence of the virus and the everincreasing body of research that have been shedding light each day. Discussion: Both COVID-19 and HUS require binding to a membrane receptor to trigger the pathophysiological mechanism. Despite the evident difference in tropism, both conditions develop with severe endothelial dysfunction, microangiopathy and important inflammatory response, responsible for MODS. The role of the coagulation pathway is more significant in COVID-19 but less in HUS. Excessive complement activation appears to be a determinant of severe prognosis in both diseases. Regarding COVID-19, children have a milder symptomatology than adults, but in some cases the paediatric inflammatory multisystem syndrome (PIMS) is described.