[Immunohistochemic staining for CK5/6 and P63 significance in prostate premalignant lesions and adenocarcinoma]. / Semnificatia imunohistochimica a CK5/6 si P63 în leziunile premaligne si î adenocarcinomul de prostata.

UNLABELLED: The morphologic information from usual hematoxiline-eosine staining are sometimes insufficient in certifying or excluding the adenocarcinoma of the prostate, cases who must be study by immunohistochemistry. AIM: The investigation of staining for CK5/6 and P63 in cases diagnosed with prostate adenocarcinoma associated with high grade prostatic intraepithelial neoplasia. MATERIAL AND METHODS: The study was realized on 56 cases analyzed in Pathology Laboratory of Focsani Emergency Hospital. RESULTS: We registered a positive correct diagnosis for atypical adenomatous hyperplasia in 86% of cases and for prostate adenocarcinoma grade 1 in 14% of cases. CONCLUSIONS: CK5/6 and P63 are useful markers for elucidating a positive false diagnosis for prostate adenocarcinoma grade 1.