RESUMO
1,4-dihydropyridines (DHPs) are biologically active. 1,4-DHP analogs with appropriate substituents also show characteristic fluorescence activity. Here, for the first time, we report a simple and easy synthesis of a novel fluorescent 1,4- DHP derivative of dibenzo[18]-crown-6 (2), which showed promising sensing ability towards physiologically important metal ions. The covalent linking of 1,4-DHP analog with dibenzo[18]-crown-6 instigates its fluorescence activity in (2) and makes it biologically relevant. (2) shows a noteworthy enhancement of fluorescence intensity toward Fe3+ and Ba2+ in methanol medium. DFT studies revealed that metal binding by the crown ether-O atoms leads to structural rigidity, enhancing the fluorescence intensity. Interestingly, (2) shows utility in the quantitative detection of Fe3+ ions in the biological (human blood serum) and food samples.
