RESUMO
Parenteral ivermectin treatment of disseminated strongyloidiasis and hyperinfection is increasing, although not licensed in humans and with limited pharmacokinetic data available. Plasma and postmortem tissue analysis in an human immunodeficiency virus (HIV)/hepatitis C virus-positive man with disseminated strongyloidiasis suggests loading subcutaneous ivermectin doses are required, from which the central nervous system is protected.
Assuntos
Antiparasitários/farmacocinética , Diarreia/diagnóstico , Infecções por HIV/diagnóstico , Hepatite C/diagnóstico , Pseudo-Obstrução Intestinal/diagnóstico , Ivermectina/farmacocinética , Estrongiloidíase/diagnóstico , Adulto , Animais , Autopsia , Diarreia/complicações , Diarreia/tratamento farmacológico , Diarreia/patologia , Evolução Fatal , Infecções por HIV/complicações , Infecções por HIV/tratamento farmacológico , Infecções por HIV/patologia , Hepatite C/complicações , Hepatite C/tratamento farmacológico , Hepatite C/patologia , Humanos , Injeções Subcutâneas , Pseudo-Obstrução Intestinal/complicações , Pseudo-Obstrução Intestinal/tratamento farmacológico , Pseudo-Obstrução Intestinal/patologia , Masculino , Strongyloides/patogenicidade , Strongyloides/fisiologia , Estrongiloidíase/complicações , Estrongiloidíase/tratamento farmacológico , Estrongiloidíase/patologiaAssuntos
Adenocarcinoma Mucinoso , Ampola Hepatopancreática/patologia , Neurofibromatose 1/patologia , Neoplasias Pancreáticas/patologia , Somatostatinoma/patologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/patologia , Adenocarcinoma Mucinoso/diagnóstico , Adenocarcinoma Mucinoso/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Neurofibromatose 1/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Somatostatinoma/diagnósticoRESUMO
A 70-year-old man, who was recently diagnosed with sclerosing mesenteritis following an abdominal biopsy, presented with an acute onset of left upper eyelid swelling, moderate ptosis, mild chemosis and restriction of movements. A computed tomography scan showed an enlarged lateral rectus muscle with surrounding soft tissue changes. A diagnosis of orbital inflammation manifesting as myositis was made and the patient was commenced on high-dose prednisolone, which showed a rapid response. It is believed that this may be a new association similar to that previously reported with retroperitoneal fibrosis and orbital inflammation.
Assuntos
Pseudotumor Orbitário/etiologia , Paniculite Peritoneal/complicações , Idoso , Glucocorticoides/uso terapêutico , Humanos , Masculino , Músculos Oculomotores/diagnóstico por imagem , Músculos Oculomotores/patologia , Pseudotumor Orbitário/diagnóstico , Pseudotumor Orbitário/tratamento farmacológico , Paniculite Peritoneal/diagnóstico , Paniculite Peritoneal/tratamento farmacológico , Prednisolona/uso terapêutico , Tomografia Computadorizada por Raios XRESUMO
This paper reviews some aspects of the application of immunohistochemistry in gynaecological pathology. The use of cytokeratins 7 and 20 are discussed with reference to applications in ovarian pathology, including metastatic disease to the ovaries. Developments in utilising MIB-1 and p16 in cervical squamous and glandular lesions are discussed. Recent assertions regarding the differential diagnosis between endocervical and endometrial carcinomas are also reviewed. Antibodies that may be of use in the diagnosis of uterine mesenchymal and ovarian tumours are highlighted, as are antibodies of use in trophoblastic lesions including the use of p57 in evaluating hydatidiform moles.
Assuntos
Carcinoma/diagnóstico , Neoplasias dos Genitais Femininos/diagnóstico , Imuno-Histoquímica/métodos , Biomarcadores Tumorais , Carcinoma/química , Feminino , Neoplasias dos Genitais Femininos/química , Humanos , Neoplasias Ovarianas/química , Neoplasias Ovarianas/diagnóstico , Neoplasias Uterinas/química , Neoplasias Uterinas/diagnóstico , Neoplasias Vulvares/química , Neoplasias Vulvares/diagnósticoRESUMO
A 65-year-old woman presented with an 8-year history of progressive frontotemporal alopecia and hirsutism. She had elevated serum levels of testosterone, androstenedione and estradiol. Ultrasound and computed tomography imaging suggested a right ovarian mass, while bilateral ovarian venous sampling demonstrated increased testosterone levels originating from both ovarian veins. Histology obtained following bilateral oophorectomy demonstrated bilateral ovarian hyperthecosis. Six months after surgery, the patient remains well with no progression of the alopecia. Ovarian hyperthecosis is a rare cause of androgenetic alopecia in postmenopausal women. The role of hyperthecosis and its relationship to androgenetic alopecia is reviewed.
