Psychological Continuum of Elderly Patients Suffering from Arterial Hypertension with Metabolic Syndrome, Against the Background of Chronotherapy with a Fixed Combination of Amlodipine, Lisinopril and Rosuvastatin.

Aim        To study the psychological continuum in elderly patients with arterial hypertension associated with metabolic syndrome during the chronotherapy with a fixed combination (FC) of amlodipine, lisinopril, and rosuvastatin.Material and methods        In the inpatient conditions, 63 patients aged 60-74 years with arterial hypertension associated with metabolic syndrome were treated with chronotherapy with a FC of amlodipine, lisinopril, and rosuvastatin (5 / 10 / 10 mg/day in the evening). These patients composed the main group. The control group (58 patients aged 60-74 years with arterial hypertension associated with metabolic syndrome) was treated with the FC of amlodipine, lisinopril, and rosuvastatin at the same dose of 5 / 10 / 10 mg/day in the morning.Results   At one year, the disorders of psychological continuum were significantly decreased with the chronotherapy (evening dosing) with the antihypertensive FC of amlodipine, lisinopril, and rosuvastatin compared to the traditional treatment (morning dosing) at the same dose of 5 / 10 / 10 mg/day in both groups. With the chronotherapeutic approach, the dynamic of cognitive disorders in patients aged 60-74 years with arterial hypertension associated with metabolic syndrome was characterized by a significant increase in the Mini-Mental-State-Examination scale score from 17.8±0.3 at baseline to 23.5±0.4 with the evening dosing (р<0.001) vs. the increase from 16.9±0.3 to 20.4±0.4 (р<0.001) with the morning dosing. The situational anxiety score decreased from 40.0±2.2 to 30.6±1.8 (р<0.05) and from 40.8±2.5 to 33.5±1.9  (р<0.05), and the trait anxiety score decreased from 48.8±2.0 to 26.4±1.9 (р<0.001) and from 44.9±1.9 to 30.7±1.7  (р<0.01) with the evening and morning dosing, respectively. Depressive disorders slightly decreased with the chronotherapy by 14.1 % vs. 7.7 % with the traditional regimen; nevertheless, they were consistent with depressive spectrum disorders in both groups.Conclusion            The study results showed a higher effectiveness of the chronotherapeutic treatment compared to the traditional treatment with FC of amlodipine, lisinopril, and rosuvastatin in arterial hypertension with metabolic syndrome.

[The information content and predictive value of cardiac markers in myocardial infarction in the elderly.]

Myocardial infarction in old age is the leading pathology and cause of deaths. The aim of the study was to evaluate the prognostic significance and informative value of cardiac markers of blood in elderly patients with myocardial infarction. The study of cardiac markers in 107 patients with myocardial infarction at the age of 65-75 years and in 83 patients with myocardial infarction at the age of 50-60 years was carried out by immunochromatographic, bioluminescent methods and by electrophoresis on cellulose acetate, followed by the calculation of informativeness and prognostic coefficients. 95 persons aged 65-75 years without myocardial infarction served as control. Troponin T, brain natriuretic peptide, glucose-6-phosphate dehydrogenase and lactate dehydrogenase-1 have the most informative and prognostic significance in elderly patients with myocardial infarction. The use of these cardiac markers will improve the diagnosis and isolation of patients with myocardial infarction at high risk.

[Improvement of laboratory diagnostics of metabolic syndrome with arterial hypertension in elderly patients.]

Metabolic syndrome (MS) is considered an age-associated pathology, often combined with hypertension (AH) and has a high prevalence in the elderly. However, a comparative study of the broad spectrum of proinflammatory and anti-inflammatory interleukins with an assessment of their informative value in elderly patients WITH MS with AH was not carried out. The aim of the study was to improve the diagnosis of MS with hypertension in elderly patients based on the analysis of the informativity of serum interleukins.. The content of interleukins in serum was studied in 86 patients with MS and AH aged 60-75 years and 35 persons without MS and AH, comparable in age and sex. It was found that for the diagnosis of S in combination with AH as the leading laboratory markers of systemic immunity it is necessary to use highly informative IL-8, IL-1B, IL-4 and IL-10. Other serum interleukins (Il-6, IL-2, TNF-α, interferon-É£, interferon-α and IL-18) can be considered as additional markers in the diagnosis of MS with hypertension in the elderly.

Extraction of the 131Cs from neutron irradiated barium oxide under microwave radiation.

In this work, the solubility dependence of radioactive baric samples under influence of microwave radiation (MWR) has been investigated at various concentrations of HCl after irradiation of BaO target at a flux of thermal neutrons. It is established that the use of MWR for dissolution of a sparingly-soluble barium oxide will accelerate a dissolution process at almost an order of magnitude in comparison with usual heating. Each time after separation of the 131Cs from radioactive barium solution analyses on radionuclide purity of the 131Cs product solutions were carried out.