[The efficacy of the ultrashort-term action insulin-lispro preparation "humalog" and the antioxidant mexidol in the complex treatment of type I diabetes in infants and adolescents].

Monitoring of a group of 96 children with type I diabetes mellitus showed the positive effect of fast-acting insulin analog humalog on the long-term glycemic control and correction of metabolic disturbances in the vegetative nervous system and on the elimination of psychological problems. Additional prescription of the antioxidant drug mexidol promoted restoration of the cardiac rhythm variability, normalization of a daily structure of the heart rate, improvement of memory and attention and decreased the level of anxiety. The observations showed a decrease in the rate of formation of the diabetic cardiac neuropathy and a reduction of expressiveness of cerebroasthenic syndrome.

[Cytoprotective properties of 3-oxy-6-methyl-2-ethylpyridine succinate in cell cultures].

Tests on calf coronary vessel cells (CVC) cultures showed that 3-oxi-6-methyl-2-ethylpiridine succinate (OMEPS) in dozes within 5.0-10.0 microg/ml did not decrease proliferation index, monolayer development, and viability factor. OMEPS also did not increase cytotoxicity index and did not change cytomorphological characteristics of the culture. In a concentration of 100 microg/ml, OMEPS exhibited some cytotoxyc properties, but to a lower degree compared to the reference antiarrhythmic drug moricisine (1.0-20.0 microg/ml). However, OMEPS (2.5 microg/ml) reduced the cytotoxicity moricisine introduced into CVC culture in a doze of 1.0 microg/ml.