[Correlation of the genetic profile and features of the rehabilitation after ischemic stroke]. / Korreliatsiia geneticheskogo profilia i osobennostei reabilitatsii posle ishemicheskogo insul'ta.

AIM: To examine an effect of polymorphisms of lipid peroxidation system genes on the risk of ischemic stroke as well as the prognosis of disease outcome after rehabilitation measures. MATERIAL AND METHODS: Seven hundred and forty-six patients with ischemic stroke and 500 patients of the control group were genotyped for 6 polymorphisms of lipid peroxidation system genes: HIF1a C1772T, ApoE Σ2/Σ3/Σ4, MnSOD C47T, GPX-1 C599T, BDNF G196T, p22phox C242T. RESULTS AND CONCLUSION: The HIF1a C1772T polymorphism was a significant risk factor for the development of ischemic stroke with the odds ratio 1.702 (p<0.05). For GPX-1 C599T and BDNF G196T polymorphisms, a trend towards a higher frequency of heterozygous genotypes was shown in patients with the negative dynamics of neurological status. The results suggest the influence of genetic variants not only on the risk of stroke but also on treatment and rehabilitation outcomes.

[Emergency laboratory diagnosis of diphtheria]. / Ekstrennaia laboratornaia diagnostika difterii.

The immune response to diphtheria toxin (clinically pronounced infection or carrier state with the presence of toxigenic bacteria) or toxoid (vaccination) the blood has been found to contain lymphocytes (1.00-5.71%), specifically binding diphtheria toxoid (DTX). The method for the determination of lymphocytes, specifically binding DTX, may serve both for early diagnosis and in the process of the disease, irrespective of the injection of therapeutic serum to the patient. The result of the test is obtained 2-3 days earlier than the positive result of the bacteriological analysis. The set of immune reagents for the rapid diagnosis of diphtheria by the method of rosette formation has been developed.

[An experimental study of the effect of immunomodulators on the immune response to the anatoxin components of adsorbed DPT vaccine against a background of poisoning]. / Izuchenie v éksperimente vliianiia immunomoduliatorov na immunnyi otvet k anaktosinnym komponentam AKDS na fone intoksikatsii.

An experiment of rabbits subjected to artificial lead intoxication revealed that after the immunization of the animals with adsorbed DPT vaccine myelopid and thymoptin exhibited practically the same immunomodulating activity with respect to antibody response to diphtheria and tetanus toxoids, exceeding that of rabbits without intoxication. Still the immunomodulators used in this experiment did not completely compensate the negative effect of intoxication on antibody response to the toxoids. For the first time after immunization with adsorbed DPT toxoid lymphocytes capable of binding diphtheria toxoid were detected and the specific features of their dynamics in comparison with the activity of antitoxin were established. Myelopid and thymoptin were found to modulate immune response, evaluated by the content of antigen-binding lymphocytes, the injection of thymoptin completely compensating the negative effect of intoxication.

[Environmental pollution and the characteristics of the epidemic process in diphtheria]. / Zagriaznenie okruzhaiushchei sredy i osobennosti épidemicheskogo protsessa difterii.

The analysis of materials for 1981-1993 on the city of Almaty and the Zhambyl, Aktyubinsk, East Kazakhstan and Kustanai provinces of the Republic of Kazakhstan made it possible to find out a number of specific features in diphtheria morbidity under the conditions of environmental pollution. It caused an increase in the number of the foci of the disease and in the proportion of bacterial carriers and diphtheria patients in the foci, the growth of the proportion of children among the patients and the proportion of toxic forms of diphtheria, the tendency towards a rise in the frequency of unfavorable outcomes of the disease. These features correspond to earlier data on the decreased immunological effectiveness of immunization with adsorbed DPT vaccine in the presence of environmental pollution in the above-mentioned territories.

[The ecological aspects of ADTP vaccination]. / Ekologicheskie aspekty AKDS-vaktsinatsii.

The results of measuring the activity of diphtheria and tetanus toxoids in the blood of 19,654 persons immunized with adsorbed DPT vaccine have shown a pronounced decrease in the effectiveness of booster immunization with adsorbed DPT vaccine. The negative influence of environmental pollution is more pronounced with respect to less active diphtheria toxoid. The possibility of the separation of the population into strata differing in the intensity of their immune response to toxoids under the influence of environmental pollution is considered.