Sweat gland carcinoma of the foot: a review and patient report.

Sweat gland neoplasms, whether benign or malignant, are rare. A case of sweat gland carcinoma occurring in the foot is represented. The literature, including clinical presentation, dermatopathology, and treatment is reviewed.

Porocarcinoma of the eyelid.

PURPOSE: The purpose of this report is to describe the clinical and histopathologic findings in a patient with porocarcinoma of the eyelid. METHODS: The case of a 68-year-old woman with a nodular lesion of the eyelid was studied, and the pertinent literature reviewed. RESULTS: No previous description of porocarcinoma of the eyelid was found in the literature. The present case presented with a nodular lesion of the right lower eyelid of 1-year duration. The tumor was completely excised. Microscopic study revealed ductal structures within lobules of tumor cells. CONCLUSIONS: Porocarcinoma is a rare cutaneous adnexal tumor arising from the eccrine secretory apparatus. Because the clinical behavior of this cancer includes deep invasion, regional lymphatic spread, and distant metastases, complete surgical excision is recommended, and should be verified by either conventional frozen sections or Mohs' micrographic sections.

Atypical fibroxanthoma of the eyelid.

Atypical fibroxanthomas are tumors that arise in the skin, show strikingly atypical cytologic features, but usually follow a benign clinical course. The authors present a case of atypical fibroxanthoma involving the eyelid. Although early reports noted a favorable prognosis, these tumors can recur aggressively and metastasize. Therefore, complete excision is recommended for atypical fibroxanthomas around the eye.

Periocular malignant fibrous histiocytoma.

We present a case of periocular cutaneous malignant fibrohistiocytoma that invaded the orbit. Complete excision is recommended for atypical fibrohistiocytic tumors around the eye. Examination of specimen margins by frozen section should be undertaken with caution. It is recommended that frozen section evaluation be performed by a pathologist familiar with spindle cell neoplasm to ensure complete removal of this tumor.

Leukemic dermal infiltrates as a complication of central venous catheter placement.

A leukemic dermal infiltrate at the site of a central venous catheter placement was the first manifestation of relapse in a 58-year-old woman in clinical remission of acute myelomonocytic leukemia. The patient developed a large hematoma around the site of an unsuccessful attempt to place a central venous (CV) catheter. Although the hematoma resolved completely by the time that complete remission was achieved, an indurated, erythematous mass subsequently developed, which when biopsied revealed leukemic cells in the dermis. The patient had a relapse in her peripheral blood shortly thereafter. The authors reviewed recent literature and their own experience with CV catheters and report on localized dermal relapse as a previously unpublished risk of CV catheter placement. They also speculate on the role of the dermis as a sanctuary for leukemic cells and a potential source for relapsing disease.

Neutrophilic eccrine hidradenitis associated with Hodgkin's disease and chemotherapy. A case report.

A 44-year-old man with Hodgkin's disease developed fever and erythematous macules and plaques associated with doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Biopsy results demonstrated a neutrophilic infiltrate around sweat glands and degeneration of eccrine glands. These findings are characteristic of neutrophilic eccrine hidradenitis, which, to our knowledge, has previously been reported only in patients with acute myelogenous leukemia who were receiving cytarabine chemotherapy. Neutrophilic eccrine hidradenitis may represent a reaction pattern to chemotherapeutic agents and may not be specific for a particular disease or drug.

Malignant Merkel cell neoplasm of the eyelid.

Malignant Merkel cell neoplasms of the eyelid are most commonly found in elderly patients. They occur most frequently on the upper eyelid and are seen as large, nontender , red or violaceous masses with intact overlying skin. Differential diagnosis includes lymphoma and oat cell carcinoma. Conventional light microscopic features are usually distinctive, but tissue should be saved for electron microscopy and immunocytochemical studies, since the presence of dense-core neurosecretory granules and perinuclear microfilaments on electron microscopic examination and positive staining for neuron-specific enolase, are strongly suggestive of malignant Merkel cell neoplasm. Because of the diffuse infiltrative growth pattern and early lymphatic spread of this tumor, treatment requires careful examination of regional lymph nodes and wide surgical excision of the tumor with frozen-section control of margins.