RESUMO
PURPOSE: The aim of the present study was to evaluate and quantify the antiangiogenetic effect of ionizing radiation on tumor angiogenesis using digital subtraction angiography (DSA) in conjunction with computer assisted image analysis (CAIA). METHODS: Walker 256 carcinosarcoma was inoculated in both glutei of 12 Wistar rats. When the tumors reached a diameter of 1.5 cm, local irradiation of the right gluteus was performed. The left gluteus of each animal served as a control. After 24 hours of irradiation, angiography was performed, and images where digitized and subsequently processed. The effect of irradiation was observed both in big and small vessels (smaller or greater than 200 microm). RESULTS: Irradiated areas of both small and big vessels showed a statistically significant reduction in both total vessel area and length. Small vessels showed a greater trend toward suppression by irradiation (not statistically significant). CONCLUSION: Irradiation had a deleterious effect in both macro- and micro-blood supply of a tumor. The use of CAIA enhanced the efficacy of DSA and enabled the in vivo identification of the effect of irradiation on various caliber vessels as well as the ratios of total length and total area of small and big vessels.
Assuntos
Angiografia Digital , Interpretação de Imagem Assistida por Computador , Neoplasias/irrigação sanguínea , Neoplasias/radioterapia , Neovascularização Patológica/diagnóstico por imagem , Neovascularização Patológica/radioterapia , Animais , Feminino , Masculino , Ratos , Ratos WistarRESUMO
A 43-year old Caucasian male with end-stage renal disease presented with painful skin lesions and high calcium phosphate product that did not respond to medical treatment. Skin biopsy confirmed the diagnosis of calciphylaxis. Urgent parathyroidectomy was performed and resulted in decrease in the calcium phosphate product and improvement of his symptoms and signs.
Assuntos
Calciofilaxia/etiologia , Calciofilaxia/cirurgia , Falência Renal Crônica/complicações , Paratireoidectomia , Adulto , Osso e Ossos/diagnóstico por imagem , Calciofilaxia/diagnóstico , Cálcio/sangue , Humanos , Masculino , Fosfatos/sangue , Radiografia , Imagem Corporal TotalRESUMO
The case of a 35-year-old man is reported who developed a spontaneous anaphylactic shock as the only clinical manifestation of hepatic hydatidosis. Dermatologists should consider asymptomatic hydatid disease in the differential diagnosis of anaphylactic reactions, particularly in patients from regions in which echinococcosis is endemic.
