RESUMO
To study the dynamics of wild rodent populations and identify potential hosts for hantavirus, we conducted an eco-epidemiologic study in Campo Novo do Parecis, Mato Grosso State, Brazil. We detected and genetically characterized Castelo dos Sonhos virus found in a species of pygmy rice rat (Oligoryzomys utiaritensis).
Assuntos
Reservatórios de Doenças/veterinária , Infecções por Hantavirus/veterinária , Orthohantavírus/genética , Doenças dos Roedores/epidemiologia , Sigmodontinae/virologia , Animais , Anticorpos Antivirais/sangue , Brasil/epidemiologia , DNA Viral/análise , Reservatórios de Doenças/virologia , Orthohantavírus/imunologia , Orthohantavírus/isolamento & purificação , Infecções por Hantavirus/epidemiologia , Infecções por Hantavirus/virologia , Filogenia , Doenças dos Roedores/virologia , Análise de Sequência de DNARESUMO
We describe evidence of circulation of hantaviruses in the influence area of the Santarém-Cuiabá Highway (BR-163) in the Brazilian Amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: Novo Progresso (2.16%) and Trairão (4.37%), in state of Pará (PA), and Gua-rantã do Norte (4.74%) and Marcelândia (9.43%), in state of Mato Grosso. We also demonstrate the ongoing association between Castelo dos Sonhos virus (CASV) and hantavirus pulmonary syndrome (HPS) cases in the Castelo dos Sonhos district (municipality of Altamira, PA) and the first report of CASV in the municipalities of Novo Progresso and Guarantã do Norte. The results of this work highlight the risk for a possible increase in the number of HPS cases and the emergence of new hantavirus lineages associated with deforestation in this Amazonian area after the conclusion of paving works on BR-163 Highway.
Assuntos
Anticorpos Antivirais/sangue , Infecções por Hantavirus/virologia , Orthohantavírus/isolamento & purificação , RNA Viral/genética , Adolescente , Adulto , Idoso , Brasil , Criança , Pré-Escolar , Feminino , Orthohantavírus/classificação , Orthohantavírus/genética , Infecções por Hantavirus/diagnóstico , Infecções por Hantavirus/epidemiologia , Síndrome Pulmonar por Hantavirus/virologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Filogenia , Reação em Cadeia da Polimerase , Estações do Ano , Estudos Soroepidemiológicos , Adulto JovemRESUMO
We describe evidence of circulation of hantaviruses in the influence area of the Santarém-Cuiabá Highway (BR-163) in the Brazilian Amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: Novo Progresso (2.16 percent) and Trairão (4.37 percent), in state of Pará (PA), and Gua-rantã do Norte (4.74 percent) and Marcelândia (9.43 percent), in state of Mato Grosso. We also demonstrate the ongoing association between Castelo dos Sonhos virus (CASV) and hantavirus pulmonary syndrome (HPS) cases in the Castelo dos Sonhos district (municipality of Altamira, PA) and the first report of CASV in the municipalities of Novo Progresso and Guarantã do Norte. The results of this work highlight the risk for a possible increase in the number of HPS cases and the emergence of new hantavirus lineages associated with deforestation in this Amazonian area after the conclusion of paving works on BR-163 Highway.
