Densidade dos mastócitos em lesões de quelite actínica / Densidad de los mastocitos en las lesiones de la queilitis actínica / Density of mast cells in lesions of actinic cheilitis

Objetivo: analisar a densidade dos mastócitos em Queilite Actínica segundo as características histológicas da lesão comparando com a mucosa normal. Método: estudo descritivo onde a amostra foi composta por dois grupos, sendo o primeiro com 33 espécimes de casos de queilite actínica diagnosticados clinicamente, e o segundo composto por 9 espécimes de mucosa oral normal, registrados no Serviço de Cirurgia de Cabeça e Pescoço do Hospital Dr. Napoleão Laureano, João Pessoa, PB. Os blocos parafinados da amostra foram cortados e corados em Hematoxilina e Eosina para avaliar o grau de displasia epitelial e infiltrado inflamatório; e por azul de toluidina para quantificar os mastócitos. A contagem dos mastócitos foi realizada com o auxilio de um retículo quadrado em 8 campos por caso. A leitura final foi expressa com o valor médio de mastócitos por caso em células/µm². Os dados foram analisados pelo SPSS (Statistical Package for Social Sciences) versão 15.0. Resultados: em 57,6 porcento dos casos houve algum grau de displasia epitelial, sendo 39,4 porcento leve, 15,2 porcento moderada e 3 porento severa. Em 21,2 porcento havia carcinoma de células escamosas. A presença de infiltrado inflamatório e elastose solar foi observada em 84,9 porcento e 81,8 porcento dos casos, respectivamente. Os mastócitos foram identificados em 87,8 porcento da amostra. A densidade dos mastócitos nos casos de queilite actínica foi de 17,4±10,4 células/µm² e no tecido normal 1,78±1,64 células/µm² (p<0,001). Houve correlação estatisticamente significante entre densidade de mastócitos com os processos de displasia (p=0,004) e infiltrado inflamatório (p=0,000). Conclusão: o aumento da densidade dos mastócitos nas lesões de queilite actínica, em relação a mucosa normal, e sua correlação com os processos de displasia e inflamação sugerem participação dessas células na progressão da doença para Carcinoma de Células Escamosas de lábio(AU)

Objective: analyze the density of mast cells in Actinic cheilitis according to the histological characteristics of the lesion compared with the normal mucosa. Methods: descriptive study where the sample consisted of two groups, the first with 33 specimens of cases of actinic cheilitis diagnosed clinically, and the second consists of 9 specimens of normal oral mucosa, registered in the Service of Head and Neck Hospital Dr. Napoleon Laureano, João Pessoa, PB. The paraffin blocks of the sample were cut and stained with hematoxylin and eosin to assess the degree of dysplasia and inflammatory infiltrate, and toluidine blue to quantify mast cells. The count of mast cells was performed with the aid of a square grid in the case of field 8. The final reading was expressed with an average value of mast cells by case / µm². Data were analyzed by SPSS (Statistical Package for Social Sciences) version 15.0. Results: in 57.6 percent of cases there was some degree of dysplasia, and 39.4 percent mild, 15.2 percent moderate and 3 percent severe. 21.2 percent had squamous cell carcinoma. The presence of inflammatory infiltrate and solar elastosis was observed in 84.9 percent and 81.8 percent , respectively. Mast cells were identified in 87.8 percent of the sample. The density of mast cells in cases of Actinic Cheilitis was 17.4 ± 10.4 cells / µm² and 1.78 ± 1.64 normal tissue cells / µm² (p <0.001). There was a statistically significant correlation between mast cell density with the processes of dysplasia (p = 0.004) and inflammatory cell infiltration (p = 0.000). Conclusion: the increase in mast cell density in actinic cheilitis lesions and its correlation with the processes of inflammation and dysplasia suggest involvement of these cells in disease progression for Squamous Cell Carcinoma lip(AU)

Objetivo: analizar la densidad de los mastocitos en la queilitis actínica según las características histológicas de la lesión en comparación con la mucosa normal. Métodos: estudio descriptivo donde la muestra consistió en dos grupos, el primero con 33 muestras de casos de queilitis actínica diagnosticados clínicamente, y el segundo se compone de 9 muestras de mucosa oral normal. Los casos estaba registardos en el servicios de Cirugía de Cabeza y Cuello del Hospital Dr. Napoleón Laureano, Joao Pessoa, PB. Los bloques de parafina de la muestra fueron cortados y teñidos con hematoxilina y eosina para evaluar el grado de displasia epitelial e infiltrado inflamatorio; y azul de toluidina para cuantificar los mastocitos. El recuento de células cebadas se realizó con la ayuda de una red cuadrada en 8 campos por caso. La lectura final se expresó con valor medio de mastocitos por células / m² ·. Los datos fueron analizados con el programa SPSS (Statistical Package for Social Sciences) versión 15.0. Resultados: En el 57,6 por ciento de los casos hubo algún grado de displasia epitelial, y 39,4 por ciento leve, 15,2 por ciento moderada y el 3 por ciento severa. El 21,2 por ciento tenían carcinoma de células escamosas. Se observó la presencia de infiltrado inflamatorio y elastosis solar en 84,9 por ciento y 81,8 por ciento, respectivamente. Se identificaron células cebadas en 87,8 por ciento de la muestra. La densidad de los mastocitos en los casos de queilitis actínica fue 17,4 ± 10,4 células / m² · tejido normal y 1.78 ± 1.64 células / m² · (p <0,001). Hubo una correlación estadísticamente significativa entre la densidad de los mastocitos con procesos de displasia (p = 0,004) y el infiltrado inflamatorio (p = 0,000). Conclusión: El aumento de la densidad de los mastocitos en la queilitis actínica, en comparación con mucosa normal, y su correlación con los procesos de displasia y la inflamación sugiere el papel de estas células en la progresión de la enfermedad para el Carcinoma de células escamosas(AU)

Síndrome de boca ardiente: claves diagnósticas y terapéuticas / Burning mouth syndrome: Diagnostic and therapeutic keys

No disponible

Flujo salival y lesión bucal en pacientes VIH+ / Salivary flow and oral lesion in HIV +

El objetivo del presente estudio fue evaluar la tasa de flujo salival y la presencia de lesiones bucales en un grupo de pacientes VIH+, en correlación con la terapia antirretroviral. Se seleccionaron 82 pacientes adultos de ambos géneros, seropositivos al VIH, que se encontraban sometidos a tratamiento en el Hospital Clementino Fraga/João Pessoa/Brasil. La muestra fue dividida en grupo experimental, con 37 individuos bajo tratamiento antirretroviral y grupo control, con 45 individuos que no se encontraban bajo tratamiento antirretroviral. Se realizó exploración clínica bucal y se determinó el flujo salival en reposo (FSR) y el estimulado (FSE). Se realizó estudio estadístico descriptivo, test de Mann-Whitney y test chi cuadrado, considerando significativos los valores de p<0,05. El promedio del FSR fue 0,34 0,18 ml/min y 0,34 0,17 ml/min en el grupo experimental y control, respectivamente. El promedio del FSE fue 1,68 0,79 ml/min en el grupo experimental y de 1,59 0,73 ml/min en el grupo control, p=0,490. La xerostomía afectó al 24,3% de los pacientes del grupo experimental y 26% del control. No hubo diferencia significativa, p=0,809. El 43% de los pacientes del grupo experimental y el 40% de los del control presentaron lesiones bucales asociadas a la infección por el VIH/SIDA. Entre ellas, la candidiasis constituyó la forma más frecuente, representando un 8,1% y 35,5%, seguida por la leucoplasia vellosa con 2,7% y 11%, sialoadenitis con 8,1% y 4,4% y ulceraciones bucales con 8,1% y 4,9% para el grupo experimental y control, respectivamente. La terapia antirretroviral no causó disfunción en las glándulas salivales y redujo la prevalencia de candidiasis bucal

The aim of this study was to evaluate the salivary flow rate and the presence of oral lesions in a group of patients HIV+, correlating with the active antiretroviral therapy (HAART). 82 adult patients HIV inflected, on treatment in the Hospital Clementino Fraga/João Pessoa/Brazil were selected. The sample was divided in experimental group, with 37 individuals on HAART and group control, with 45 individuals not on HAART. Oral clinical exploration was realized and it determined unstimulated and stimulated salivary flow rates. The test of Mann-Whitney and chi-square test were used, considering the values of p<0.05 significant. The average of the unstimulated salivary flow was 0.34±0.18 ml/min and 0.34±0.17 ml/min in the experimental and control groups respectively. The average of the stimulated salivary flow was 1.68±0.79 ml/min in the experimental group and of 1.59±0.73 ml/min in the group control, p=0.490. The xerostomia affected 24.3% of the patients of experimental group and 26% of the control. p=0.809. 43% of the patients in the experimental group and 40% of the patients in the control group presented HIV - associated oral lesions. The candidiasis was the most frequent (8.1% and 35.5%), followed by hairy leukoplakia (2.7% and 11%), sialoadenosis (8.1% and 4.4%) and ulcerations (8.1% and 4.9%) for the experimental and control groups respectively. The antiretroviral therapy did not cause dysfunction in the salivary glands and reduced the prevalence of oral candidiasis

Multiple myeloma with primary manifestation in the mandible: a case report.

Multiple myeloma is a monoclonal malignant proliferation of plasma cells that causes osteolytic lesions in the vertebrae, ribs, pelvic bone, skull and jaw. We report on a clinical case of an 81-year-old male patient who presented with a tumefaction in the mandibular symphysis region, which had evolved over the previous seven months. In the radiographic examination, an extensive osteolytic lesion was observed in the region mentioned above. An incisional biopsy was performed and a histopathological study revealed a malignant hematopoietic neoplasm formed by plasmacytoid cells. During the bone gammagraphy a dissemination of the disease was detected in the scapula, clavicle and ribs. The diagnosis was multiple myeloma. Knowledge about the maxillofacial manifestations of multiple myeloma is important for the early diagnosis of the disease, since its primary form can manifest itself in the jaw. In the clinical case presented here, we highlight the interdisciplinarity needed to obtain a diagnosis and treatment of multiple myeloma.

Asociación de síndrome de boca ardiente con xerostomía y medicamentos / Association of burning mouth syndrome with xerostomia and medicines

Objetivo: Identificar factores de riesgo para el síndrome de boca ardiente (SBA) a través de estudio de casos y controles.Material y métodos: Se realizó análisis cuantitativo del flujo salival total en reposo y estimulado; se registraron la xerostomía subjetiva, el consumo de medicamentos y los estados psicológicos de ansiedad y depresión en 40 pacientes con SBA y 40 controles.Resultados: El análisis ANOVA mostró diferencias significativas en las medias del número de medicamentos/día, número de medicamentos xerostomizantes/día, xerostomía subjetiva, ansiedad y depresión, entre los grupos estudiados. No se observaron diferencias significativas en las tasas de flujo salival en reposo y estimulado. El análisis de asociación Odds ratio determinó asociación del SBA con xerostomía y con el consumo de hipotensores y diuréticos.Conclusiones: Según los resultados de este estudio, se puede afirmar que el consumo de hipotensores y diuréticos fue un factor de riesgo para el padecimiento del SBA. La función de las glándulas salivales en los pacientes con SBA no está deteriorada

Objective: A case control study to identify risk factors for burning mouth syndrome (BMS). ;;Material and Methods: Quantitative analysis was carried out on the total salivary flow at rest and stimulated; subjective xerostomia, ingestion of medicines and the psychological states of anxiety and depression in 40 patients with BMS and 40 controls. ;;Results: The ANOVA analysis showed significant differences in the means of the number of medicines/day, number of xerostomising agents/day, subjective xerostomia, anxiety and depression, between the groups studied. No significant differences were seen in the at rest or stimulated saliva flow rates. The odds ratio analysis determined the association of BMS with xerostomia and the consumption of hypotensives and diuretics. ;;Conclusions: From the results of this study, it can be shown that the consumption of hypotensives and diuretics was a risk factor for the development of BMS. The function of the salivary glands in patients with BMS is not affected

Tuberous sclerosis and its oral manifestations. A clinical case.

Tuberous sclerosis (TS) is a congenital anomaly in the development of the embryo which is transmitted through the autosomal dominant gene. It has various forms of clinical expression. It is classified as one of what are known as Phacomatoses (phakos stain and oma tumour), which are development anomalies that can originate tumours and/or hamartomas in the nervous system. Lesions in the nervous system are nearly always accompanied by cutaneous anomalies. In this study we introduce the case of a woman patient aged 55, diagnosed several years earlier with Tuberous Sclerosis, who attended for intraoral lesions which were clinically compatible with fibromata. These lesions of fibrous appearance occurred above all on the lower lip and in both cheeks' mucous membranes, little mentioned in the literature as a site for such a manifestation of TS. The pathological anatomy suggested lesions compatible with Angiomyolipoma. In addition, the data referring to TS are reviewed; its implications for the mouth are described; and histopathological results are used to examine the significance of the word Angiomyolipoma.

Burning mouth and saliva.

Stomatodynia is the complaint of burning, tickling or itching of the oral cavity, and can be associated with other oral and non-oral signs and symptoms. However, the oral mucosa often appears normal, with no apparent underlying organic cause to account for the symptomatology. The etiology is unknown, though evidence points to the participation of numerous local, systemic and psychological factors. Among the local factors, saliva may play an important role in the symptoms of burning mouth. Saliva possesses specific rheological properties as a result of its chemical, physical and biological characteristics - these properties being essential for maintaining balanced conditions within the oral cavity. Patients with burning mouth present evidence of changes in salivary composition and flow, as well as a probable alteration in the oral mucosal sensory perception related particularly to dry mouth and taste alterations. On the other hand, alterations in salivary composition appear to reflect on its viscosity and symptomatology of burning mouth. Saliva is a field open to much research related to burning mouth, and knowledge of its properties (e.g., viscosity) merits special attention in view of its apparent relationship to the symptoms of burning mouth. The present study describes our clinical experience with burning mouth, and discusses some of the aspects pointing to salivary alterations as one of the most important factors underlying stomatodynia.

La función masticatoria en el anciano / Masticatory function in elderly people

La función oral está intrínsecamente relacionada con actividades diarias esenciales como la alimentación y la comunicación. Además tiene un papel fundamental en las relaciones del individuo con otras personas y en la conservación del autoestima. Con el envejecimiento se producen cambios en las estructuras bucodentales que, junto a la variación del estado de salud oral y general, determinan el deterioro habitual de la función oral. No obstante, las personas mayores suelen adaptarse a muchos de los cambios del sistema estomatognático, conducentes muchas veces a limitaciones en la función oral. En este artículo se hace una breve revisión de los cambios de la función oral en el anciano centrada en la masticación (AU)