Assuntos
Asma , Espasmo Brônquico , Criança , Humanos , Serviço Hospitalar de Emergência , Sons RespiratóriosAssuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Asma/terapia , Espasmo Brônquico/terapia , Serviço Hospitalar de Emergência , Sons Respiratórios , Recidiva , Estudos RetrospectivosAssuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Toxidermias/diagnóstico , Toxidermias/etiologia , Etoricoxib/efeitos adversos , Ativação Linfocitária/imunologia , Linfócitos/imunologia , Anti-Inflamatórios não Esteroides/administração & dosagem , Etoricoxib/administração & dosagem , Feminino , Humanos , Linfócitos/metabolismo , Pessoa de Meia-IdadeAssuntos
Amiodarona/efeitos adversos , Basófilos/imunologia , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/etiologia , Bloqueadores dos Canais de Potássio/efeitos adversos , Idoso de 80 Anos ou mais , Teste de Degranulação de Basófilos , Basófilos/metabolismo , Biomarcadores , Hipersensibilidade a Drogas/tratamento farmacológico , Hipersensibilidade a Drogas/metabolismo , Humanos , Imunoglobulina E/imunologia , Imunofenotipagem , Imunossupressores/farmacologia , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-IdadeRESUMO
INTRODUCTION: Children with asthma experience recurrent respiratory symptoms and exacerbations due to multiple environmental factors. The aim of this study was to describe the prevalence and triggers of asthma exacerbations and their management in a cohort of pediatric patients attended in an emergency department (ED). METHODS: We performed an observational, retrospective, single-center study in the pediatric ED of Hospital Universitario La Paz, Madrid, Spain in 2015. Children with asthma exacerbations attending the ED were included after a thorough search using our institutional computer database. Pollen and atmospheric mold spore counts and pollution data were collected for that period from official websites. Multiple logistic regression was used to assess the association between daily pollution (NO2, PM10, ozone, pollen, and molds) and admissions to the ED because of asthma. RESULTS: During 2015, a total of 50 619 patients were attended in the ED of our hospital. Of these, 2609 (5%) were diagnosed with asthma exacerbation/bronchospasm. The patient had to be admitted to hospital in 21.7% of cases. The main triggers of asthma exacerbations were respiratory infection in 1841 cases (70.6%). A significant correlation was found between grass pollen counts and ED admissions (P<.0001). A positive correlation was also found between ED admissions and NO2 0.58 (95%CI, 0.02-0.87) and PM10 0.75 (95%CI, 0.31-0.93) (P<.05). CONCLUSION: Environmental factors such as grass pollen counts and pollution (NO2 and PM10) are associated with a higher frequency of admission to the ED.
