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1.
Braz J Med Biol Res ; 33(9): 1059-63, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10973138

RESUMO

Neurocysticercosis (NCC) is a common neurological disorder especially in developing countries, caused by infection of the brain with encysted larvae of the tapeworm Taenia solium. Seizures are a common finding associated with this disease. The objective of the present study was to evaluate the correlation between the levels of various cytokines present in the cerebrospinal fluid (CSF) of patients with NCC and the severity of the disease. The levels of the cytokines IL-1ss, TNF-alpha, IL-5, IL-10 and IFN-gamma were determined in the CSF of 22 patients with active NCC, 13 patients with inactive NCC and 15 control subjects. CSF from patients with active NCC presented significantly higher IL-5 levels compared to control subjects. IL-5 and IL-10 levels in CSF from NCC patients with inflammatory CSF were significantly higher than those detected in non-inflammatory CSF. These results show a predominant Th2 lymphocyte activation in human NCC and also indicate the possible use of cytokines in the CSF as a marker for the differential diagnosis between inactive disease and the active form of NCC.


Assuntos
Citocinas/líquido cefalorraquidiano , Neurocisticercose/líquido cefalorraquidiano , Animais , Anticorpos Anti-Helmínticos , Estudos de Casos e Controles , Cysticercus/imunologia , Ensaio de Imunoadsorção Enzimática , Humanos , Interferon gama/líquido cefalorraquidiano , Interleucina-1/líquido cefalorraquidiano , Interleucina-10/líquido cefalorraquidiano , Interleucina-5/líquido cefalorraquidiano , Fator de Necrose Tumoral alfa/líquido cefalorraquidiano
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;33(9): 1059-63, Sept. 2000.
Artigo em Inglês | LILACS | ID: lil-267971

RESUMO

Neurocysticercosis (NCC) is a common neurological disorder especially in developing countries, caused by infection of the brain with encysted larvae of the tapeworm Taenia solium. Seizures are a common finding associated with this disease. The objective of the present study was to evaluate the correlation between the levels of various cytokines present in the cerebrospinal fluid (CSF) of patients with NCC and the severity of the disease. The levels of the cytokines IL-1î, TNF-alpha, IL-5, IL-10 and IFN-gamma were determined in the CSF of 22 patients with active NCC, 13 patients with inactive NCC and 15 control subjects. CSF from patients with active NCC presented significantly higher IL-5 levels compared to control subjects. IL-5 and IL-10 levels in CSF from NCC patients with inflammatory CSF were significantly higher than those detected in non-inflammatory CSF. These results show a predominant Th2 lymphocyte activation in human NCC and also indicate the possible use of cytokines in the CSF as a marker for the differential diagnosis between inactive disease and the active form of NCC


Assuntos
Humanos , Citocinas/líquido cefalorraquidiano , Interleucina-10/líquido cefalorraquidiano , Interleucina-5/líquido cefalorraquidiano , Neurocisticercose/líquido cefalorraquidiano , Anticorpos Anti-Helmínticos , Contagem de Células Sanguíneas , Estudos de Casos e Controles , Líquido Cefalorraquidiano/citologia , Cysticercus/imunologia , Ensaio de Imunoadsorção Enzimática , Interferon gama/líquido cefalorraquidiano , Interleucina-1/líquido cefalorraquidiano , Fator de Necrose Tumoral alfa/líquido cefalorraquidiano
3.
Arq Neuropsiquiatr ; 56(1): 93-7, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9686127

RESUMO

Based on their own experience and on the literature, the authors compare the brain pathology due to HIV+ associated Trypanosoma cruzi reactivated infection to that described for the natural history of the Chagas' disease (CD). The peculiar focal necrotizing chagasic meningoencephalitis (MECNF) which appears only in immunedeficient chagasics, especially when the deficiency is due HIV is a safe criterion for reactivation of CD. MECNF morphologic findings are unlike to those found either for some cases of acute phase CD or for chronic nervous form of CD.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/fisiopatologia , Encéfalo/patologia , Doença de Chagas/patologia , Meningoencefalite/parasitologia , Doença Aguda , Doença Crônica , Humanos
4.
Arq Neuropsiquiatr ; 56(1): 133-6, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9686136

RESUMO

Terson's syndrome is characterized by the presence of a subarachnoid hemorrhage accompanied by retinal and vitreous hemorrhage leading to a not very favorable prognosis. We describe a case with a good outcome, probably because of a early diagnosis and medical intervention. We emphasize the routine optician's check up as very important in the evaluation of a prognosis in the cases of a suspect intracranial hemorrhage.


Assuntos
Hemorragia Retiniana/diagnóstico , Hemorragia Subaracnóidea/diagnóstico , Hemorragia Vítrea/diagnóstico , Adulto , Feminino , Seguimentos , Humanos , Hemorragia Retiniana/complicações , Hemorragia Subaracnóidea/complicações , Síndrome , Hemorragia Vítrea/complicações
5.
Rev Soc Bras Med Trop ; 31(2): 163-71, 1998.
Artigo em Português | MEDLINE | ID: mdl-9608234

RESUMO

Twenty-two HIV+ patients with encephalitis were studied. Of these, 7 had meningoencephalitis due to Toxoplasma gondii (MT) and 15 due to Trypanosoma cruzi (MC). Pathologic and computerized axial tomography (CAT) changes were compared. We found that focal necrotizing encephalitis due to Toxoplasma involved the cerebral cortex and the basal ganglia, whereas lesions due to Trypanosoma cruzi were centered in the white matter, sometimes extending into the cortex. Hemorrhages, myelin lesions and organisms were more pronounced in chagasic than in toxoplasmic encephalitis. These findings are consistent with the literature reviewed.


Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Doença de Chagas/diagnóstico , Meningoencefalite/parasitologia , Toxoplasmose/diagnóstico , Doença de Chagas/parasitologia , Doença de Chagas/patologia , Diagnóstico Diferencial , Humanos , Meningoencefalite/diagnóstico por imagem , Meningoencefalite/patologia , Radiografia , Toxoplasmose/diagnóstico por imagem , Toxoplasmose/parasitologia , Toxoplasmose/patologia
6.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;31(2): 163-171, mar.-abr. 1998. ilus, tab
Artigo em Português | LILACS | ID: lil-464110

RESUMO

Em 22 pacientes com sorologia positiva para o vírus da imunodeficiência humana, com ou sem síndrome da imunodeficiência adquirida, dos quais 7 com meningoencefalite toxoplásmica e 15 com meningoencefalite chagásica associadas, procuraram-se dados diferenciais, entre as duas encefalopatias, tanto à anatomia patológica quanto à tomografia computadorizada do crânio. Os resultados observados e os dados da literatura nos permitiram concluir que enquanto na meningoencefalite necrosante focal por Toxoplasma gondii o acometimento dos núcleos da base é freqüente, na meningoencefalite necrosante focal causada pelo Trypanosoma cruzi, lesões dessas estruturas parecem não ocorrer ou ser excepcionais. De outro lado, o acometimento da substância branca parece nitidamente maior na meningoencefalite chagásica que na meningoencefalite toxoplásmica, ao passo que o parasitismo e a hemorragia do tecido nervoso, bem como as lesões das bainhas de mielina são mais freqüentes e intensos na meningoencefalite causada pelo Trypanosoma cruzi que naquela por Toxoplasma.


Twenty-two HIV+ patients with encephalitis were studied. Of these, 7 had meningoencephalitis due to Toxoplasma gondii (MT) and 15 due to Trypanosoma cruzi (MC). Pathologic and computerized axial tomography (CAT) changes were compared. We found that focal necrotizing encephalitis due to Toxoplasma involved the cerebral cortex and the basal ganglia, whereas lesions due to Trypanosoma cruzi were centered in the white matter, sometimes extending into the cortex. Hemorrhages, myelin lesions and organisms were more pronounced in chagasic than in toxoplasmic encephalitis. These findings are consistent with the literature reviewed.


Assuntos
Humanos , Doença de Chagas/diagnóstico , Meningoencefalite/parasitologia , Síndrome da Imunodeficiência Adquirida/complicações , Toxoplasmose/diagnóstico , Diagnóstico Diferencial , Doença de Chagas/parasitologia , Doença de Chagas/patologia , Meningoencefalite/patologia , Meningoencefalite , Toxoplasmose/parasitologia , Toxoplasmose/patologia , Toxoplasmose
7.
Rev Soc Bras Med Trop ; 24(2): 101-4, 1991.
Artigo em Português | MEDLINE | ID: mdl-1841424

RESUMO

The frequency of strokes was studied in chronic chagasic and years of age, non-chagasic patients, older than 15 coming to necropsy in Uberaba, from 1979 than 1988. The study consisted of paired sex and age matched controls. Two hundred and eight pairs were analysed. Either ischemic or hemorrhagic strokes were found in 41 (19.7%) of the chagasics and in 55 (26.4%) of the non-chagasic, a difference not significant at the level of 5%. Twelve (75%) of the former had infarcts and 4 (25%) had brain hemorrhage; five (31.3%) of the non-chagasics had ischemic strokes and 11 (68.7%) had hemorrhagic strokes. The differences were significant to the level of 5%. The results indicate a high frequency of ischemic strokes in human Chagas' disease and demonstrate a lesser frequency of hemorrhagic stroke in chagasics when compared with non-chagasics.


Assuntos
Transtornos Cerebrovasculares/parasitologia , Doença de Chagas/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Análise por Pareamento , Pessoa de Meia-Idade
8.
Braz J Med Biol Res ; 20(3-4): 441-4, 1987.
Artigo em Inglês | MEDLINE | ID: mdl-3330464

RESUMO

Eighteen of nineteen patients reported relief from chronic pain (40 to 100%, analogue scale) lasting from a few hours to up to two months after single or repeated regional infusion of dipyrone into a limb. A tendency towards increased duration of pain relief was observed after repeated infusions. The present series of observations in man and experiments with rat paw hyperalgesia are consistent with the interpretation that dipyrone blocks a persistent hyperalgesic state which may result from a previous frequent nociceptive stimulation (memory?) rather than an ongoing inflammatory process.


Assuntos
Aminopirina/análogos & derivados , Analgesia/métodos , Dipirona/uso terapêutico , Nociceptores/efeitos dos fármacos , Animais , Doença Crônica , Ensaios Clínicos como Assunto , Dipirona/administração & dosagem , Humanos , Infusões Intra-Arteriais , Projetos Piloto , Ratos
9.
Arq. bras. neurocir ; 3(2): 119-23, 1984.
Artigo em Português | LILACS | ID: lil-22142

RESUMO

E apresentado 1 paciente, portador de 2 cistos gigantes na regiao frontal, que apresentou sintomatologia clinica de hipertensao intracraniana e sinal neurologico focal. Justifica-se a apresentacao do caso pelo fato de, contrariamente ao tratamento cirurgico empregado na literatura (craniotomia + exerese), ter sido utilizada drenagem atraves de sistema valvular de baixa pressao (cisto-cavidade peritoneal) e a seguir tratamento com praziquantel com o que desapareceram os cistos


Assuntos
Pessoa de Meia-Idade , Humanos , Masculino , Cisticercose , Encefalopatias , Procedimentos Cirúrgicos Operatórios , Tomografia Computadorizada por Raios X
10.
Arq Neuropsiquiatr ; 36(3): 210-5, 1978 Sep.
Artigo em Português | MEDLINE | ID: mdl-687155

RESUMO

A bibliographical revision about Silverstein's amyotrophy, with a historical sight analizing the physiopathogeny and its clinical manifestations is reported. The authors discussed the possible cause of the few references in the literature about the matter and relate three cases; they leave a blank in one of them with amyotrophy in the other side and the same side of the lesion, that got better with surgical treatment. This was not found in the bibliographical revision that has been looked for.


Assuntos
Neoplasias Encefálicas/complicações , Atrofia Muscular/etiologia , Lobo Parietal , Adulto , Neoplasias Encefálicas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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