RESUMO
INTRODUCTION: The British Antarctic Survey Medical Unit works in a very remote area of the world, with several Antarctic bases receiving only a single annual resupply of consumable goods. Pharmaceuticals supplied in this manner will often be approaching or past the end of their nominal shelf life before the following year's resupply. Drugs are transported from the UK via ship; the hold is not temperature controlled, and the ship crosses through the tropics (air temperature 25-30°C for approximately 3 wk). The drugs then must be transported from the ship to the base, often in temperatures substantially below freezing. This study assessed the stability of 5 expired drugs (atropine, nifedipine, flucloxacillin, naproxen, and bendroflumethiazide) returned from Antarctic bases. METHODS: Drugs were opportunistically obtained and tested using stability-indicating assays. RESULTS: All tested drugs were stable. CONCLUSIONS: The results suggest that the studied drugs may be stable beyond expiry, even when not maintained in strictly temperature-controlled conditions.
