RESUMO
El lupus eritematoso profundo es una variante rara de lupus eritematoso cutáneo que afecta fundamentalmente al tejido celular subcutáneo. Describimosun caso en una mujer de 58 años de edad con lesiones nodulares subcutáneas en nalgas, brazos y espalda. Las lesiones desaparecierondejando una lipoatrofia severa y desfigurante (AU)
Lupus erythematosus profundus is an unusual variant of cutaneous lupus erythematosus that mainly affecting the subcutaneous fat. We report acase on a 58 year-old woman with deep subcutaneous nodules in buttocks, arms and back. The lesions dissappeared leaving severe and desfiguringlipo-atrophy (AU)
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Lúpus Eritematoso Cutâneo/diagnóstico , Paniculite de Lúpus Eritematoso/diagnóstico , Clobetasol/uso terapêutico , Triancinolona Acetonida/uso terapêuticoRESUMO
Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75 % of neoplastic cells. Currently it is considered a low grade lymphoma with favourable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up.
Assuntos
Linfócitos Nulos/patologia , Linfoma Anaplásico de Células Grandes/patologia , Linfoma não Hodgkin/patologia , Neoplasias Cutâneas/patologia , Idoso de 80 Anos ou mais , Feminino , Humanos , Imunofenotipagem , Úlcera da Perna/etiologia , Linfoma Anaplásico de Células Grandes/diagnóstico , Linfoma Anaplásico de Células Grandes/radioterapia , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/radioterapia , Indução de Remissão , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/radioterapiaRESUMO
El linfoma cutáneo primario anaplásico de células grandes CD30+ (LCPCG) forma parte del espectro de las enfermedades cutáneas primarias linfoproliferativas CD30+, junto a la papulosis linfomatoide. Afecta fundamentalmente a pacientes de edad avanzada, en forma de nódulos cutáneos con tendencia a la ulceración. El estudio histológico e inmunohistoquímico demuestra la expresión del antígeno CD30 en más del 75 % de las células neoplásicas. Actualmente se considera un linfoma de bajo grado de malignidad, con buen pronóstico y buena respuesta a tratamientos como la radioterapia local, el metotrexato o la cirugía. Presentamos un caso en una paciente de 93 años con nódulos ulcerados en la pierna derecha. El estudio histológico e inmunohistoquímico confirmó el diagnóstico de LCPCG CD30+, de origen no T no B. La paciente fue tratada con radioterapia local con resolución paulatina de los nódulos cutáneos y sin mostrar recidiva en los 6 meses de seguimiento
Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75 % of neoplastic cells. Currently it is considered a low grade lymphoma with favourable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up
