RESUMO
Twenty-two male and 20 female adults with Down's syndrome were examined. Ten of the men and two of the women had a follicular rash consistent with Malassezia folliculitis. Oral itraconazole treatment produced a significant improvement in the rash, accompanied by a decrease in the skin Malassezia count. Clinical relapse occurred when therapy was discontinued, and was accompanied by return of the Malassezia yeasts.
Assuntos
Síndrome de Down/complicações , Foliculite/microbiologia , Malassezia , Administração Oral , Adulto , Síndrome de Down/patologia , Feminino , Foliculite/tratamento farmacológico , Foliculite/patologia , Humanos , Itraconazol/administração & dosagem , Itraconazol/uso terapêutico , Masculino , Recidiva , Pele/patologiaRESUMO
Anorexia Nervosa (A.N.) is a relatively common eating disorder with well recognised psychological and physiological features. A study of 14 female patients with A.N. revealed a number of dermatological disorders, including lanugo hair, xeroderma and hyperpigmentation. Laboratory investigations revealed various abnormalities including elevated Beta-carotene levels, abnormal sex hormone and thyroid function. An unusual finding was the development of acne in a small subset of patients at the time of weight gain, during recovery from A.N. Anorexia Nervosa represents a useful model for the interaction between eating disorders, endocrine function and the skin.
