RESUMO
The diagnosis of acephalgic migraine is complicated by the fact that other neurological conditions such as transient ischaemic attacks, demyelinating disease, simple partial epilepsy, and even glaucoma, can present with similar symptoms. Using both flash and pattern stimulation, visual evoked potentials (VEPs) were examined as a means of differentiating between acephalgic migraine, migraine with aura, migraine without aura, demyelinating disease and a control group. This study demonstrated that by analysing the amplitude of the background fast activity in the flash and pattern VEP, acephalgic migraine can be differentiated from demyelinating disease, migraine with aura, migraine without aura and absolute controls.
Assuntos
Potenciais Evocados Visuais , Transtornos de Enxaqueca/complicações , Doenças do Sistema Nervoso/etiologia , Escotoma/etiologia , Adulto , Idoso , Doenças Desmielinizantes/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/diagnósticoRESUMO
The visual evoked responses (VERs) to both flash and pattern stimulation were recorded in 44 children with migraine, with or without aura, and 8 with periodic syndrome. The controls were 50 age and sex matched children. VERs of 50 sex matched adults with migraine were also recorded. The fast wave amplitude in children with migraine was higher than that in controls. The amplitude was higher in younger children with migraine (under 13 years) than that in older children or adults with migraine. Children with periodic syndrome had VERs similar to those of children with migraine. The VER, especially in children, may prove to be a useful test in the diagnosis of migraine.
Assuntos
Potenciais Evocados Visuais/fisiologia , Transtornos de Enxaqueca/diagnóstico , Adolescente , Adulto , Criança , Pré-Escolar , Estudos de Avaliação como Assunto , Febre Familiar do Mediterrâneo/complicações , Febre Familiar do Mediterrâneo/fisiopatologia , Feminino , Humanos , Masculino , Transtornos de Enxaqueca/fisiopatologiaRESUMO
Patients with acute closed-angle glaucoma were treated with a hydrophilic contact lens saturated in 1, 4, or 8 per cent. pilocarpine or bt intensive 4 per cent. pilocarpine drops. The greatest hypotensive response was produced by the 1 per cent. presoaked lens and increased strength of soaking solution gave reduced response. Intensive drops gave the least response. In vitro studies show that the lens is effectively saturated after 2 hrs' soaking holds c. 700 mug. pilocarpine and yields almost all of the contained pilocarpine after 2 hrs' elution. The method of lens preparation is described and pharmaceutical studies confirm a shelf life of 4 months in a domestic refrigerator.
Assuntos
Lentes de Contato Hidrofílicas , Glaucoma/tratamento farmacológico , Pilocarpina/administração & dosagem , Acetazolamida/uso terapêutico , Doença Aguda , Administração Tópica , Humanos , Pilocarpina/uso terapêutico , Tecnologia Farmacêutica , Fatores de TempoRESUMO
Hydrophilic gel contact lenses, presoaked in various strength saline solutions, were held in intimate contact with the in vivo human cornea. A change in corneal water content was observed taking place against the induced osmotic gradient. Direct stimulation of some aspect of the mechanisms controlling corneal hydration is postulated, in a manner which may be similar to that previously reported for the in vitro rabbit cornea.
