[Optic nerve pilocytic astrocytoma with retinal involvement]. / Astrocitoma pilocítico de nervio óptico con afectación de retina.

INTRODUCTION: This is an atypical case of a pilocytic astrocytoma that involved the optic nerve (ON) and the retina. CLINICAL CASE: The patient was a 30-year-old male, who had attended ONCE since his early childhood because of the suspicion of an intraocular tumor. The ophthalmology exploration showed an ON and retinal coloboma in the right eye and microphthalmy, shutting of the pupil, retinal detachment and proof of an intraocular tumor in the left eye. The MR revealed an ON tumor that involved the retina. The histopathological study after enucleation was pilocytic astrocytoma. DISCUSSION: Long standing congenital pathology in a blind patient does not exclude the possibility of the patient suffering from other pathology as well.

Astrocitoma pilocítico de nervio óptico con afectación de retina / Optic nerve pilocytic astrocytoma with retinal involvement

Introducción: Se presenta un caso atípico de astrocitoma pilocítico de nervio óptico (NO) y retina.Caso clínico: Varón de 30 años afiliado a la ONCE desde niño, con sospecha de tumoración intraocular. En la exploración oftalmológica: coloboma de NO y retina en ojo derecho y microftalmos, seclusión pupilar, desprendimiento de retina y evidencia de una masa retiniana en ojo izquierdo. La RNM mostró una tumoración de NO y retina. El estudio anatomopatológico tras la enucleación diagnosticó astrocitoma pilocítico de NO y de retina.Discusión: La existencia de una patología congénita en un paciente con ceguera legal no excluye el que pueda presentar otras patologías

Introduction: This is an atypical case of a pilocytic astrocytoma that involved the optic nerve (ON) and the retina. Clinical case: The patient was a 30-year-old male, who had attended ONCE since his early childhood because of the suspicion of an intraocular tumor. The ophthalmology exploration showed an ON and retinal coloboma in the right eye and microphthalmy, shutting of the pupil, retinal detachment and proof of an intraocular tumor in the left eye. The MR revealed an ON tumor that involved the retina. The histopathological study after enucleation was pilocytic astrocytoma. Discussion: Long standing congenital pathology in a blind patient does not exclude the possibility of the patient suffering from other pathology as well

[Granuloma annulare of the eyelid: an unusual presentation]. / Granuloma anular del párpado: una localización poco frecuente.

CASE REPORT: Granuloma annulare is a benign dermatosis, relatively common during childhood, usually self-limited and of unknown etiology. Localized ocular involvement is rare. We report a case of granuloma annulare involving the eyelid of a child. A biopsy taken from a similar lesion presented later on the back of a thumb confirmed the diagnosis. Treatment with topical corticosteroids was introduced. DISCUSSION: The literature on periocular granuloma annulare is reviewed. This diagnosis should be considered for any acquired papular of the periorbital area, especially if there is a history of antecedent trauma. Unnecessary surgical excision can then be avoided.

Granuloma anular del párpado: una localización poco frecuente / Granuloma annulare of the eyelid: an unusual presentation

Caso Clínico: El granuloma anular es una dermatosis, benigna, autolimitada, relativamente frecuente en la infancia, de etiología desconocida. La afectación periocular es rara. Se presenta un caso de granuloma anular que aparece en el párpado superior de una niña. Una biopsia tomada de una lesión del dorso del dedo pulgar aparecida posteriormente confirmó el diagnóstico. Fue instaurado un tratamiento con corticosteroides. Discusión: Se hace una revisión de los granulomas perioculares descritos en la literatura. Se debe sospechar este diagnóstico ante toda pápula adquirida en la región periocular, especialmente si existe historia de traumatismo previo. El diagnóstico correcto puede evitar la escisión quirúrgica (AU)

[Epidermoid cancer of the penis: our experience]. / Cáncer epidermoide de pene: nuestra experiencia.

OBJECTIVES: We reviewed our series of epidermoid penile cancer to determine the predictive index of lymph node invasion and the incidence of phimosis in these patients. METHODS: We reviewed the records of 11 patients with epidermoid cancer of the penis. Six patients had been evaluated according to a protocol that included preoperative biopsy of the lesion, penile and abdominal ultrasound evaluation, CT and diagnostic lymphadenectomy for those cases suspected as having lymph node invasion. The predictive index (PI) was determined in relation to the grading of cell differentiation (G) and tumor stage (S) [PI = G+T] and the incidence of phimosis was sought during the interview. RESULTS: Lymph node invasion was confirmed in 2 patients with PI = 6 and in 1 patient with PI = 5. Diagnostic lymphadenectomy showed no evidence of lymphatic spread in 1 patient with PI = 3 and in another patient with PI = 4. The remaining 6 patients with PI < 2 did not undergo lymphadenectomy. Phimosis was associated in 73% of the cases. CONCLUSIONS: PI is a reliable index for lymph node invasion. Patients with PI < 4 do not require therapeutic lymphadenectomy. Phimosis should be operated early in childhood.

[Expression of p53 in prostatic carcinoma]. / Expresión de p53 en carcinomas de próstata.

The expression of the p53 protein was studied in 10 men with prostate cancer by means of an immunohistochemical method. Strong staining for p53 was found in six of ten prostate cancer (60%, mean: 26% of malignant cells stained in the positive tumours). On the other hand, the cell nuclei in benign glands did not stain positively. Immunohistochemical pattern of p53 was not related significantly to clinicopathologic parameters in the cases examined. However, significant relationship was observed between prostate cancer stage D and stage B and mean of expression of p53 in both groups. Also, relationship between mean of expression of p53 of tumoral cells of grade IV and mean of expression of p53 of tumoral cells of grades I, II and III was observed.

[Transitional carcinoma of the prostate. Report of a case treated with chemotherapy]. / Carcinoma transicional de próstata. A propósito de un caso tratado con quimioterapia.

A case of transitional cell carcinoma of the prostate is described which had been diagnosed following TUR of the prostate due to cervico-prostatic obstruction. Subsequent cystoscopic and cytological controls, as well as multiple bladder biopsies have discarded a concomitant urothelial tumor. We underscore the rarity of transitional cell tumor of the prostate, its response to chemotherapy and the possibility of suspecting this tumor type when there is massive invasion of the prostate following TUR.

[Rhabdomyosarcoma of the epididymis]. / Rabdomiosarcoma de epidídimo.

A 5-year-old boy with intrascrotal rhabdomyosarcoma arising from the epididymis is described. The patient was submitted to radical orchidectomy via the inguinal approach and high ligation of the spermatic cord. The anatomopathological examination revealed germ cell rhabdomyosarcoma of the epididymis with no testicular or spermatic cord involvement, which corresponded to stage I of the IRS classification (Intergroup Rhabdomyosarcoma Study). Its clinical and histological features and treatment are discussed.

[Epithelioid sarcoma]. / Sarcoma epitelioide.

A description is given of an epithelioid sarcoma observed in a male patient of 71 years of age. This two-year growth was located in the right leg and presented a clinical picture of a hard walled ulcer. After having been removed surgically the tumour reappeared after seven months at which point amputation was practised at the middle thigh. The patient died twelve months after amputation suffering from pleuropulmonary metastasis. An necropsy was not carried out. The finding of massive arterial neoplastic thrombosis in the histological study confirms the fatal outcome of the patient. The clinical, histological, evolutive and therapeutic characteristics of the epithelioid sarcoma are reviewed.