RESUMO
Monoclonal therapies could represent baseline-personalized medicine for patients with neoplasia. One of the most successful examples is Trastuzumab, a humanized antibody against epidermal growth factor receptor 2. Human epidermal growth factor receptor 2 (HER2) is a trans-membrane tyrosine kinase coded by the gene HER2/neu and overexpressed in approximately 12% to 20% of infiltrating breast carcinomas. The overexpression of HER2 is an independent adverse prognostic factor in relation to survival and is also predictive of response to treatment. Therefore, the correct evaluation of HER2 status is essential for the management of infiltrating breast carcinoma to determine the response to Trastuzumab. The most common evaluation technique is immunohistochemistry, which is confirmed by fluorescent or chromogenic monochrome or dual-gene in situ hybridization in ambiguous cases (immunohistochemical 2+). Our objective was to evaluate the diagnostic value of a new technique on the basis of HER2 mRNA in situ hybridization (HistoSonda) and study its correlation with immunohistochemistry and dual-chromogenic in situ hybridization (DUO-CISH) in 403 cases of infiltrating breast carcinoma. The percentage of DUO-CISH amplification was 25.8%, HistoSonda positivity was 31.2%, and positivity for Hercep-Test was 48.1%, including (+2) and (+3). Comparisons were made of each of the techniques, HistoSonda to IHQ and HistoSonda to DUO-CISH. The overall concordance between DUO-CISH and HistoSonda was 89%. Our data support the consistency of HistoSonda as a useful tool to determine HER2 status in breast cancer.
Assuntos
Biomarcadores Tumorais/genética , Neoplasias da Mama/diagnóstico , Carcinoma Ductal de Mama/diagnóstico , Hibridização In Situ/métodos , RNA Mensageiro/metabolismo , Receptor ErbB-2/genética , Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/metabolismo , Carcinoma Ductal de Mama/metabolismo , Erros de Diagnóstico , Feminino , Humanos , Técnicas de Diagnóstico Molecular , Estudos Prospectivos , RNA Mensageiro/genética , Receptor ErbB-2/metabolismo , Estudos Retrospectivos , EspanhaRESUMO
La lesión de Dieulafoy es una rara anomalía vascular causa de hemorragias gastrointestinales masivas. Se caracteriza por el sangrado de una arteriola submucosa a través de una erosión en la mucosa, por otra parte normal. Aunque la lesión de Dieulafoy fue inicialmente descrita en el estómago y el tracto digestivo superior, también se han comunicado casos en el colon, recto y en canal anal. Publicamos el primer caso de lesión de Dieulafoy en la vesícula biliar que se presentó como una hemorragia peritoneal masiva. Describimos las características clínico-patológicas de esta inusual entidad, así como el abordaje de su diagnóstico y tratamiento(AU)
Dieulafoy's lesion is an uncommon vascular anomaly causing massive gastrointestinal hemorrhage, characterized by bleeding from an arteriole that protrudes through a tiny mucosal defect. Although Dieulafoy's lesion was initially described in the stomach and upper gastrointestinal tract, cases have also been reported in the colon, rectum and anal canal. We report the first case of Dieulafoy's lesion in the gallbladder, which presented as massive peritoneal bleeding. We describe the clinical and pathological characteristics of this unusual entity, as well as the approach to its diagnosis and treatment (AU)
Assuntos
Humanos , Masculino , Idoso , Hemobilia/etiologia , Hemoperitônio/etiologia , Hemorragia Gastrointestinal/etiologia , Vesícula Biliar/lesões , Lesões do Sistema Vascular/complicações , ColecistectomiaRESUMO
Dieulafoy's lesion is an uncommon vascular anomaly causing massive gastrointestinal hemorrhage, characterized by bleeding from an arteriole that protrudes through a tiny mucosal defect. Although Dieulafoy's lesion was initially described in the stomach and upper gastrointestinal tract, cases have also been reported in the colon, rectum and anal canal. We report the first case of Dieulafoy's lesion in the gallbladder, which presented as massive peritoneal bleeding. We describe the clinical and pathological characteristics of this unusual entity, as well as the approach to its diagnosis and treatment.
Assuntos
Artérias/anormalidades , Vesícula Biliar/irrigação sanguínea , Hemobilia/etiologia , Hemoperitônio/etiologia , Idoso , Humanos , MasculinoRESUMO
El carcinoma adenoide quístico es un tumor maligno que se origina en las glándulas salivares mayores o accesorias. La localización nasosinusal de estos tumores es rara. Se presenta un caso de carcinoma adenoide quístico del seno etmoidal anterior y se realiza una revisión de la literatura
Adenoid cystic carcinoma is a malignant tumour arising from major and minor salivary glands. Within the nasosinusal sinus it is uncommon. A case of adenoidcystic carcinoma of etmoidal sinus is presented along with a review of the literature
