Early detection of and intervention for two newborns with critical congenital heart disease using a specialized device as part of a screening system.

Screening for critical congenital heart disease is a clinical method used for their early detection using pulse oximetry technology. This, followed by a diagnostic confirmatory protocol, allows timely therapeutic interventions that improve the newborn's outcome. According to Mexican birth statistics, approximately 18,000-21,000 neonates are born with a form of congenital heart disease each year, of which 25% are estimated to be critical congenital heart disease. We report two cases with an early critical congenital heart disease detection and intervention through an innovative critical congenital heart disease screening program implemented in two Mexican hospitals. They integrated a new automated pulse oximetry data analysis method and a comprehensive follow-up system (Cárdi-k®). Both cases were confirmed by echocardiogram, which served for an intervention in the first week of life, and the patients were discharged in good clinical condition. In addition, to the routine physical assessments, the critical congenital heart disease screening program (which includes echocardiogram for presumptive positive cases) should be implemented in a timely manner.

La activación progresiva del sistema límbico (Kindling): un modelo de aprendizaje y plasticidad cerebral / Progressive activation of the limbic system (Kindling): a learning and brain plasticity model

Después de una breve revisión del concepto de Sistema Límbico (SL), se describen una serie de experimentos de nuestro laboratorio, utilizando el análisis de potenciales evocados sensoriales y repuestas paroxísticas en diversos modelos de epilepsia experimental: metrazol, electrochoque, focos corticales con cobalto, aplicación tópica repetida de penicilina y estimulación eléctrica breve y periódica de la amígdala del lóbulo temporal (kindling). Estos dos últimos modelos, por su cronicidad y permanencia, nos han permitido establecer medidas de cambios plásticos cerebrales con localizaciones precisas. En estos experimentos se implementaron programas para el análisis computacional (RFM) de la posdescarga paroxística y de las respuestas eléctricas sensoriales. Se describen las modificaciones en la organización del sueño, así como el efecto inhibidor del sueño paradójico o MOR sobre los paroxismos del Kindling químico o eléctrico