The Language of Nature and Artificial Intelligence in Patient Care.

Given the development of artificial intelligence (AI) and the conditions of vulnerability of large sectors of the population, the question emerges: what are the ethical limits of technologies in patient care? This paper examines this question in the light of the "language of nature" and of Aristotelian causal analysis, in particular the concept of means and ends. Thus, it is possible to point out the root of the distinction between the identity of the person and the entity of any technology. Nature indicates that the person is always an end in itself. Technology, on the contrary, should only be a means to serve the person. The diversity of their respective natures also explains why their respective agencies enjoy diverse scopes. Technological operations (artificial agency, artificial intelligence) find their meaning in the results obtained through them (poiesis). Moreover, the person is capable of actions whose purpose is precisely the action itself (praxis), in which personal agency and, ultimately, the person themselves, is irreplaceable. Forgetting the distinction between what, by nature, is an end and what can only be a means is equivalent to losing sight of the instrumental nature of AI and, therefore, its specific meaning: the greatest good of the patient. It is concluded that the language of nature serves as a filter that supports the effective subordination of the use of AI to its specific purpose, the human good. The greatest contribution of this work is to draw attention to the nature of the person and technology, and about their respective agencies. In other words: listening to the language of nature, and attending to the diverse nature of the person and technology, personal agency, and artificial agency.

Assessment of CFH and HTRA1 polymorphisms in age-related macular degeneration using classic and machine-learning approaches.

BACKGROUND: CFH and HTRA1 are pivotal genes driving increased risk for age-related macular degeneration (AMD) among several populations. Here, we performed a hospital-based case-control study to evaluate the effects of three single nucleotide polymorphisms (SNPs) among Hispanics from Mexico. MATERIALS AND METHODS: 122 cases and 249 controls were genotyped using Taqman probes. Experienced ophthalmologists diagnosed AMD following the American Association of Ophthalmology guidelines. We studied CFH (rs1329428, rs203687) and HTRA1 (rs11200638) SNPs thoroughly by logistic regression models (assuming different modes of inheritance) and machine learning-based methods (ML). RESULTS: HTRA1 rs11200638 is the most significant polymorphism associated with AMD in our studied population. In a multivariate regression model adjusted for clinically and statistically meaningful covariates, the A/G and A/A genotypes increased the odds of disease by a factor of 2.32 and 7.81, respectively (P < .05) suggesting a multiplicative effect of the polymorphic A allele. Furthermore, this observation remains statistically meaningful in the allelic, dominant, and recessive models, and ML algorithms. When stratifying by phenotype, this polymorphism was significantly associated with increased odds for geographic atrophy (GA) in a recessive mode of inheritance (12.4, p < .05). CONCLUSIONS: In sum, this work supports a strong association between HTRA1 genetic variants and AMD in Hispanics from Mexico, especially with GA. Moreover, ML was able to replicate the results of conventional biostatistics methods unbiasedly.

Design and Analysis for Fall Detection System Simplification.

This paper presents a methodology based on multimodal sensors to configure a simple, comfortable and fast fall detection and human activity recognition system that can be easily implemented and adopted. The methodology is based on the configuration of specific types of sensors, machine-learning methods and procedures. The protocol is divided into four phases: (1) database creation (2) data analysis (3) system simplification and (4) evaluation. Using this methodology, we created a multimodal database for fall detection and human activity recognition, namely UP-Fall Detection. It comprises data samples from 17 subjects that perform 5 types of falls and 6 different simple activities, during 3 trials. All information was gathered using 5 wearable sensors (tri-axis accelerometer, gyroscope and light intensity), 1 electroencephalograph helmet, 6 infrared sensors as ambient sensors, and 2 cameras in lateral and front viewpoints. The proposed novel methodology adds some important stages to perform a deep analysis of the following design issues in order to simplify a fall detection system: a) select which sensors or combination of sensors are to be used in a simple fall detection system, b) determine the best placement of the sources of information, and c) select the most suitable machine learning classification method for fall and human activity detection and recognition. Even though some multimodal approaches reported in literature only focus on one or two of the above-mentioned issues, our methodology allows simultaneously solving these three design problems related to a human fall and activity detection and recognition system.

A vision-based approach for fall detection using multiple cameras and convolutional neural networks: A case study using the UP-Fall detection dataset.

The automatic recognition of human falls is currently an important topic of research for the computer vision and artificial intelligence communities. In image analysis, it is common to use a vision-based approach for fall detection and classification systems due to the recent exponential increase in the use of cameras. Moreover, deep learning techniques have revolutionized vision-based approaches. These techniques are considered robust and reliable solutions for detection and classification problems, mostly using convolutional neural networks (CNNs). Recently, our research group released a public multimodal dataset for fall detection called the UP-Fall Detection dataset, and studies on modality approaches for fall detection and classification are required. Focusing only on a vision-based approach, in this paper, we present a fall detection system based on a 2D CNN inference method and multiple cameras. This approach analyzes images in fixed time windows and extracts features using an optical flow method that obtains information on the relative motion between two consecutive images. We tested this approach on our public dataset, and the results showed that our proposed multi-vision-based approach detects human falls and achieves an accuracy of 95.64% compared to state-of-the-art methods with a simple CNN network architecture.

UP-Fall Detection Dataset: A Multimodal Approach.

Falls, especially in elderly persons, are an important health problem worldwide. Reliable fall detection systems can mitigate negative consequences of falls. Among the important challenges and issues reported in literature is the difficulty of fair comparison between fall detection systems and machine learning techniques for detection. In this paper, we present UP-Fall Detection Dataset. The dataset comprises raw and feature sets retrieved from 17 healthy young individuals without any impairment that performed 11 activities and falls, with three attempts each. The dataset also summarizes more than 850 GB of information from wearable sensors, ambient sensors and vision devices. Two experimental use cases were shown. The aim of our dataset is to help human activity recognition and machine learning research communities to fairly compare their fall detection solutions. It also provides many experimental possibilities for the signal recognition, vision, and machine learning community.