Assuntos
Transmissão Vertical de Doenças Infecciosas , Infecções por Polyomavirus/epidemiologia , Infecções por Polyomavirus/transmissão , Dermatopatias/epidemiologia , Dermatopatias/virologia , Adolescente , Adulto , Fatores Etários , Anticorpos/sangue , Camarões , Criança , Pré-Escolar , Feminino , Doenças do Cabelo , Humanos , Lactente , Recém-Nascido , Masculino , Mães , Razão de Chances , Polyomavirus , Infecções por Polyomavirus/imunologia , Estudos Soroepidemiológicos , Dermatopatias/imunologia , Adulto JovemRESUMO
Merkel cell polyomavirus (MCPyV) is linked to a cutaneous cancer mainly occurring in Caucasians. DNA from skin swabs of 255 adults, originating from the 5 continents, were subjected to MCPyV PCRs. Phylogenetic analyses demonstrate the existence of 5 major geographically related MCPyV genotypes (Europe/North America, Africa [sub-Saharan], Oceania, South America, and Asia/Japan).
Assuntos
Carcinoma de Célula de Merkel/epidemiologia , Poliomavírus das Células de Merkel/genética , Epidemiologia Molecular , Infecções por Polyomavirus/epidemiologia , Infecções Tumorais por Vírus/epidemiologia , Adulto , Idoso de 80 Anos ou mais , Carcinoma de Célula de Merkel/virologia , DNA Viral/genética , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , Filogenia , Reação em Cadeia da Polimerase/métodos , Infecções por Polyomavirus/virologia , Infecções Tumorais por Vírus/virologia , Adulto JovemRESUMO
Merkel cell polyomavirus (MCPyV) is thought to be the etiological agent of Merkel cell carcinoma, but little is known about its distribution and modes of transmission. We conducted seroepidemiological surveys in more than 1000 individuals, from two populations from Cameroon. Overall MCPyV seroprevalence was high in both populations (>75% in adults). Data from the first population, comprising mainly children, indicated that MCPyV infections mostly occurred during early childhood, after the disappearance of specific maternal antibodies. Results from the second family-based population provided evidence for familial aggregation of MCPyV infection status. We observed significant sib-sib correlation (odds ratio=3.42 [95% CI 1.27-9.19], p=0.014), particularly for siblings close together in age, and a trend for mother-child correlation (OR=2.71 [0.86-8.44], p=0.08). Overall, our results suggest that MCPyV infection is acquired through close contact, possibly involving saliva and/or the skin, especially between young siblings and between mothers and their children.
