Perspectives for self-driving labs in synthetic biology.

Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the world is probed, interpreted, and explained by machines for human benefit. While there are functioning SDLs in the fields of chemistry and materials science, we contend that synthetic biology provides a unique opportunity since the genome provides a single target for affecting the incredibly wide repertoire of biological cell behavior. However, the level of investment required for the creation of biological SDLs is only warranted if directed toward solving difficult and enabling biological questions. Here, we discuss challenges and opportunities in creating SDLs for synthetic biology.

Eczema de contacto agudo a parafenilendiamina contenida en tatuajes transitorios con henna / Acute contact eczema from paraphenylendiamine contained in temporary henna tattoos

La henna es una planta con propiedades colorantes que se usa, en ocasiones, mezclada con otras sustancias, como tinte para el pelo y el cuerpo. La parafenilendiamina (PPD) es uno de los aditivos que se emplea para acelerar el secado, mejorar la definición, y oscurecer su color rojizo. Existen varias descripciones en la literatura médica de sensibilización a PPD contenida en henna. Describimos 3 nuevos casos de dermatitis de contacto alérgica a tatuajes transitorios, con pruebas epicutáneas positivas para PPD en dos de ellos. En uno de los pacientes las lesiones se resolvieron dejando una hipopigmentación persistente. Es importante que la población conozca esta circunstancia y el riesgo que conlleva sensibilizarse a la PPD

Henna is a plant with coloring properties which is used as a dye for hair and skin, on occasion mixed with other substances. Paraphenylendiamine (PPD) is one of the additives used to accelerate drying, improve definition and darken its reddish color. There are several descriptions in literature of sensitization to the PPD contained in henna. We describe 3 new cases of allergic contact dermatitis to temporary tattoos, with skin tests positive for PPD in 2 of them. The lesions resolved in one of the patients, leaving persistent hypopigmentation. It is important for the population to be aware of this circumstance and the risk entailed by sensitization to PPD