Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27
Filtrar
1.
Worldviews Evid Based Nurs ; 20(6): 525-531, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37905584

RESUMO

BACKGROUND: During the COVID-19 pandemic, acute care nurse managers functioned in a critical role by helping to advance the mission and goals of their organization while navigating a rapidly evolving healthcare landscape. This resulted in high levels of ongoing job-related stress which is linked to negative physical, psychological, and job-related outcomes. Little is known about the perceptions regarding their own professional well-being during this time. AIM: The aim of this study was to qualitatively describe acute care nurse managers' perceptions of and barriers to their professional well-being. METHODS: Using a qualitative descriptive approach, nurse managers from a hospital system in the southwestern United States responded to two short-answer, survey-based questions in 2022: (1) "Describe the definition of nurse-manager well-being in your own words" and (2) "What do you feel is your biggest barrier to professional well-being?" Reflexive thematic analysis was utilized to analyze participant responses (N = 80). RESULTS: Professional well-being is a complex concept influenced by the nurse manager's ability to navigate work-life balance; care for their own physical, emotional, and spiritual selves; give and receive support from stakeholders; and manage feelings of thriving vs. struggling in the role. Barriers most cited as influencing well-being included having too little time to get things done coupled with increasing workloads, feeling stuck in the middle among stakeholders, and coping with ongoing staffing challenges. LINKING EVIDENCE TO ACTION: The definition of and barriers to well-being are influenced by the specific needs and experiences of the nurse manager. While not all barriers can be immediately removed, the identification of individual and organization-specific barriers needs to be taken seriously, reviewed by those who can promote change, and evidence-based solutions for improvement piloted or implemented when feasible.


Assuntos
Enfermeiros Administradores , Estresse Ocupacional , Humanos , Enfermeiros Administradores/psicologia , Pandemias , Hospitais , Capacidades de Enfrentamento
2.
Worldviews Evid Based Nurs ; 20(2): 126-132, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37031350

RESUMO

BACKGROUND: Nurse managers have experienced tremendous stress during the COVID-19 pandemic, contributing to negative psychological outcomes. Positive professional well-being is a construct that can be promoted to mitigate poor psychological outcomes and burnout in nurses. Little is known about the health, healthy behaviors, effects of stress on homelife, and well-being of nurse managers in the United States (U.S.). AIMS: The aims of the study were to explore nurse managers' well-being related to self-reported stress and health perceptions and habits. METHODS: A sample of 80 (41% response rate) nurse managers responded to a cross-sectional web-based survey sent via email in a southwestern U.S. 13-hospital system. Nurses answered 39 quantitative questions about demographics, well-being (9-item Well-Being Index [WBI]), perceptions of stress affecting homelife, and perceptions of health and health-related behaviors. RESULTS: Mean WBI (2.9 [2.7]) indicated risk for poor psychological outcomes. Managers (75%) reported stress from work affected their personal lives and a decline in overall health during the pandemic. Most (80%) reported burnout and emotional problems. Nurse managers had 8.1 times increased risk of poor WBI scores if stress from work affected their personal life than if they reported no spillover stress into their personal life (OR = 8.1, 95% CI [2.6, 25.0]). LINKING EVIDENCE TO ACTION: Findings from this study add a nuanced understanding of nurse managers' well-being. The strongest risk factor for poor WBI scores was stress levels affecting personal life. Interventions to improve well-being in nurse managers are needed. Limitations are the convenience sampling, limited geographic location, and response rate of <50%. Further research is needed to support nurse managers in stress reduction and development of boundaries that prohibit the spillover effect of workplace stress. Organizations may consider a combination of administrative support and changes as well as provision of on-the-job training of interventions that support individual well-being.


Assuntos
Esgotamento Profissional , COVID-19 , Enfermeiros Administradores , Humanos , Saúde Mental , Enfermeiros Administradores/psicologia , Estudos Transversais , Pandemias , Satisfação no Emprego , COVID-19/epidemiologia , Esgotamento Profissional/psicologia , Inquéritos e Questionários , Medição de Risco
3.
J Holist Nurs ; 41(2): 142-154, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35620800

RESUMO

Background: Nursing students face unique academic and clinical workloads linked to increased stress. Previous studies indicate formal and informal mindfulness meditation provide stress-reducing benefits. This practice aligns with holistic nursing core values of self-care and self-reflection; little is known about meditation practice in nursing students. Objectives: Our study aimed to describe meditation practice and predictors in pre-licensure nursing students. Design: Cross-sectional, multi-site. Methods: Qualtrics surveys queried individual demographics, personal meditation and exercise habits, and indicators of wellbeing. Results: Of 417 participants, 65% (n = 271) reported at least one type of meditation practice. Prayer/spiritual activities were most prevalent (almost 70%), followed by breathing exercises (41%). Meditators reported good or excellent self-rated health status or engaged in exercise (p < .05). Meditators also reported more self-compassion, happiness, and satisfaction with life, and perceived less stress than non-meditators (p < .05). Of all factors studied, only engaging in exercise significantly predicted practicing meditation (OR = 2.05, 95%CI 1.10-3.82). Conclusion: Nursing students who engage in meditation report signs of health and well-being and utilize holistic methods such as prayer and breathing. The intrinsic motivation to engage in healthy habits such as exercise may also help students engage in mindfulness meditation and is an important finding for nursing educators.


Assuntos
Meditação , Estudantes de Enfermagem , Humanos , Meditação/métodos , Estudos Transversais , Estresse Psicológico/terapia , Satisfação Pessoal
4.
J Prof Nurs ; 38: 45-53, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35042589

RESUMO

BACKGROUND: Nursing students are at increased risk for the consequences of stress on wellbeing. Little is known about nursing students' health promoting behaviors and how these relate to health, stress, and well-being. PURPOSE: The purpose was to describe perceived stress and measures of well-being (self-compassion, happiness, and life satisfaction) along with self-reported health promoting behaviors and health status in order to identify factors that could affect stress and well-being in nursing students. METHODS: A multi-site team employed cross-sectional research methods to explore well-being, stress, and potential physical and emotional health-relevant factors in undergraduate nursing students. Baccalaureate Nursing students from three nursing programs in North Texas participated in a web-based survey. Undergraduate students (n = 417) reported being junior or senior level in a traditional (74.1%) or an alternative nursing training program (on-line, fast-track, or weekend nursing program; 24.9%) in the fall of 2019. Recruitment fliers went to a total of 2264 potential participants via university e-mail. Consenting students completed online surveys collecting demographic and health related factors as well as measures of well-being and stress. RESULTS: More than half (56.6%) of students reported worsening health since starting nursing school. Exercise and meditation were related to higher measures of well-being and lower stress, but this relationship diminished in the multivariate model when considering individual demographic and health related factors. Our multivariate model suggests that self-rated health status remains a main potential predictor of reduced stress and improved well-being. CONCLUSIONS: Self-reported health factors are related to wellbeing in nursing students. Targeted interventions to improve well-being among nursing students may be necessary and would fit with national recommendations for nursing education programs. Resiliency skills training with mindfulness practices may help nursing students reduce stress, improve overall well-being, and equip students to avoid burnout and stress-related illness once in the workforce.


Assuntos
Bacharelado em Enfermagem , Estudantes de Enfermagem , Estudos Transversais , Comportamentos Relacionados com a Saúde , Humanos , Autocompaixão , Estresse Psicológico , Inquéritos e Questionários
5.
J Allied Health ; 50(3): e87-e90, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34495037

RESUMO

Our interprofessional team examined the mental health effects of a pilot mindfulness meditation workshop for college students (n = 39) from 4 health professions. A mixed-methods survey examined students' self-compassion (short form; SCS-sf), perceived stress (PSS-10), and self-reported mindfulness behaviors pre-workshop and at 2 months. The survey captured attitudes, beliefs, and intentions to continue mindfulness practices over time and perceived barriers to mindfulness practice. Participants (69%; 27/39) indicated significantly improved SCS-sf (p=0.016) and significantly reduced PSS (p=0.009) at 2 months post-workshop. Students reported improved mental health after 2 months, but the small sample size limits generalizability of findings. Interprofessional education promoting mindfulness skills may help prevent burnout and empathy fatigue for health professionals entering the workplace.


Assuntos
Atenção Plena , Estudantes de Ciências da Saúde , Ocupações em Saúde , Humanos , Saúde Mental , Estresse Psicológico/prevenção & controle
6.
J Perianesth Nurs ; 35(2): 140-146, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31959507

RESUMO

PURPOSE: The purpose was to examine if children experience weight-based risks for post-tonsillectomy pain (PTP) in the postanesthesia care unit (PACU). DESIGN: This retrospective correlational cohort design included a sample of 180 children between the ages of 4 to 12 years who had tonsillectomy and adenoidectomy or tonsillectomy before August 2016; half were obese (OB) or overweight (OW). METHODS: The sample was obtained from children who had surgery at a large pediatric hospital with an attached outpatient surgical center in North Texas. Children were defined as either OB and OW or non-OB and non-OW based on a cutoff of standardized body mass index z scores of 85th percentile and greater per the National Center for Health Statistics. Pain scores were obtained in the PACU after surgery. Early PTP was defined as the most severe pain experienced by a child in the first 15 minutes after extubation. Prolonged PTP was sustained and uncontrolled pain in the PACU. FINDINGS: OB and OW status did not increase the likelihood of experiencing early PTP when examined by multiple logistic regression controlling for covariates (adjusted odds ratio, 1.391; P = .369). OB and OW status was associated with longer episodes of prolonged PTP (rs[178] = 0.16; P = .03). OB and OW children were more likely to experience prolonged PTP in the PACU (χ2[1] = 8.353; P = .004), with these children experiencing an average PTP period twice as long as their peers. CONCLUSIONS: OB and OW children did experience risk for prolonged PTP, averaging sustained pain for approximately twice as long as other children. The increased risk for prolonged PTP in OB and OW children occurred despite well-managed early PTP with rates that matched those of their peers. No weight-based risk for early PTP was observed. Further research is needed in the area of PTP management in OB and OW children.


Assuntos
Índice de Massa Corporal , Sobrepeso/complicações , Dor Pós-Operatória/etiologia , Tonsilectomia/efeitos adversos , Criança , Pré-Escolar , Estudos de Coortes , Correlação de Dados , Feminino , Humanos , Masculino , Sobrepeso/fisiopatologia , Manejo da Dor/métodos , Manejo da Dor/normas , Dor Pós-Operatória/fisiopatologia , Estudos Retrospectivos , Fatores de Risco , Texas , Tonsilectomia/métodos
7.
J Perianesth Nurs ; 34(6): 1106-1119, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31307907

RESUMO

An estimated 100,000 obese (OB) and overweight (OW) children undergo tonsillectomy each year in the United States. Pain management in this population is particularly challenging because of weight-based dosing, clinician fears, potential for airway obstruction, and genetic differences. A framework is proposed to explain factors involved in the post-tonsillectomy pain (PTP) experience in OB and OW children. The tonsillectomy, the body's inflammatory state, and mechanical stressors comprise influencing factors in PTP progression. Clinician-delivered medication doses, genetic variants of drug metabolism, and soothing factors serve as mediating factors in the progression of PTP. Postanesthesia care unit (PACU) nurses may use this framework to better understand PTP progression in OB and OW children. PACU nurses may manipulate certain mediating factors discussed in this framework to moderate PTP progression in OB and OW children. Researchers may use this framework to support future research to improve PTP management in OB and OW children.


Assuntos
Obesidade/complicações , Sobrepeso/complicações , Dor/etiologia , Tonsilectomia/efeitos adversos , Criança , Progressão da Doença , Humanos , Inflamação/complicações , Dor/complicações , Dor/enfermagem , Dor/fisiopatologia , Enfermagem em Pós-Anestésico , Tonsilectomia/enfermagem
8.
Adv Emerg Nurs J ; 37(4): 281-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26509725

RESUMO

This study addresses the development of a modified early warning system (MEWS) to predict hospital admissions from emergency departments (EDs) using the 2010 National Hospital Ambulatory Medical Care Survey (NHAMCS). A MEWS score was created for each patient in the NHAMCS data set using the vital signs recorded at admission. Multiple logistic regression analyses indicated that for every 1 unit increase in the MEWS score, patients were 33% more likely to be admitted to the hospital for further care even after controlling for demographics. Females were 19% less likely to be admitted and older persons were more likely to be admitted. A MEWS score of 13 resulted in almost 90% chance of admission to the hospital. Results indicate that an early warning system may be used to identify signs of physiological decline in many health care settings. Use of MEWS in EDs could be a helpful predictor of the need for hospitalization and could serve as a focus for early decision making and as a point of comparison for efficacy of interventions both in the emergency department and if the patient is admitted to the hospital.


Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Indicadores Básicos de Saúde , Hospitalização , Adolescente , Adulto , Idoso , Enfermagem em Emergência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação em Enfermagem , Valor Preditivo dos Testes , Fatores de Risco , Inquéritos e Questionários , Estados Unidos
9.
J Pediatr Nurs ; 30(6): 888-95, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25707869

RESUMO

Nurses', respiratory therapists' (RTs), and physicians' concerns about oxygen weaning practices and pulse oximetry use in healthy children during inpatient admissions prompted this multidisciplinary evidence-based project. A nurse-led inter-professional team found lack of consistent oxygen weaning practices and lack of guidelines for nurses or RTs regarding pulse oximetry use with children admitted for acute respiratory illness. The team created and piloted evidence-based oxygen weaning and pulse oximetry protocols. After a 6 month pilot, children in the pilot had shorter length of stay, time on oxygen, and time on continuous pulse oximetry. Protocols improved patient outcomes and decreased associated charges.


Assuntos
Asma/terapia , Bronquiolite/terapia , Tempo de Internação , Oximetria/métodos , Oxigênio/uso terapêutico , Asma/diagnóstico , Bronquiolite/diagnóstico , Criança , Pré-Escolar , Progressão da Doença , Medicina Baseada em Evidências , Feminino , Hospitalização , Humanos , Pacientes Internados , Masculino , Oxigênio/sangue , Equipe de Assistência ao Paciente/organização & administração , Projetos Piloto , Terapia Respiratória/métodos , Medição de Risco , Fatores de Tempo , Resultado do Tratamento
11.
Urology ; 84(1): 237-42, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24857271

RESUMO

OBJECTIVE: To determine the feasibility of a novel low-barrier-to-entry image guidance system. METHODS: Initially a randomized crossover study was performed to establish the interface (iPad or 3-dimensional mouse) that minimized both the amount of time required to perform a manual image registration and the error of that registration. A subsequent clinical feasibility study was undertaken on 5 patients undergoing robot-assisted partial nephrectomy. Randomized crossover study primary outcomes were time to task completion, NASA-Task Load Index score, and alignment error (translational and rotational). The Mann-Whitney U test was used to compare groups. Surgeon feedback was sought when assessing the system in a clinical setting. RESULTS: In the initial randomized crossover study, the iPad-based system was able to achieve adequate alignment accuracy (Frobenius norm of 0.3; total error of 20.8 mm) in significantly less time (33 seconds; P<.01) than the 3-dimensional mouse interface. The platform received good feedback from the operating surgeon in all instances with the surgeon commenting particularly on the improved appreciation of hilar vascular anatomy. CONCLUSION: In this study, we have demonstrated the feasibility of a "low-barrier-to-entry" image guidance system in a clinical setting. The system was able to achieve swift and sufficiently accurate alignment, with little impact on the surgical workflow.


Assuntos
Imageamento Tridimensional , Nefrectomia/métodos , Robótica , Software , Cirurgia Assistida por Computador , Estudos Cross-Over , Humanos
12.
J Perianesth Nurs ; 29(2): 94-106, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24661479

RESUMO

INTRODUCTION: Tonsillectomy causes discomfort in children. Positive therapeutic suggestions (TS) may be given to patients while they are emerging from general anesthesia as a potential tool to decrease distress. PURPOSE: This study examined impact of TS on outcomes, when delivered to children emerging from general anesthesia post tonsillectomy. DESIGN: A double blinded randomized controlled trial was conducted with 94 patient/parent pairs. METHODS: TS and noise recordings were played via headphones post tonsillectomy upon arrival to the Post Anesthesia Care Unit until the child showed signs of waking. FINDINGS: Pain scores at 30 minutes post extubation show significantly lower pain in the TS group, P = .04 (Mann Whitney U for independent samples). The TS group had 70% increased likelihood of receiving less intravenous (IV) opioid. CONCLUSION: TS may help lower pain in children post tonsillectomy and decrease demand for IV opioid pain management in the 4- to 8-year-old tonsillectomy population.


Assuntos
Anestesia Geral , Tonsilectomia/efeitos adversos , Criança , Método Duplo-Cego , Humanos
13.
J Robot Surg ; 4(2): 117-22, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27628777

RESUMO

This retrospective study of the largest single center experience (100 patients) with off-pump robotically assisted coronary procedures in the United Kingdom (April 2002-June 2008) aimed to rationalize patient selection, describe the technique, and determine the learning curve, technical feasibility and operative outcome of robotically assisted Atraumatic Coronary Artery Bypass (ACAB). Selected patients underwent either a robotic Totally Endoscopic Coronary Artery Bypass (12) or robotically assisted ACAB (88) using a standard Da Vinci robot with three arms. A fifth of all cases had percutaneous interventions as part of a hybrid strategy. The majority of patients were overweight men. After one hundred robotic coronary procedures, this operation is now performed as part of a routine theatre list. The mean operative and total procedure times for robotically assisted atraumatic procedures were 157 and 238 min, respectively. These measurements were significantly less in the atraumatic than the totally endoscopic group with a 34.3 and 20.6% reduction, respectively (P < 0.001; equal variance not assumed). The procedural learning curve was short and independent from internal thoracic artery harvesting. We have proven conclusively that robotically assisted ACAB is feasible, more so than the totally endoscopic procedure in this particular setting. Even in the absence of an ideal stabilizer device, this procedure causes minimal disruption to the daily operating room schedule. We have also proven that body mass index is a weak predictor of the ease of robotic internal thoracic artery harvesting and should not affect patient selection.

14.
J Exp Zool B Mol Dev Evol ; 312(2): 118-35, 2009 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-19051317

RESUMO

In a previous study (Li et al., 2001. J Exp Zool 290:18-30) a nude mouse model was established to investigate deer antler development. In that study we found nude mice could support the singularly implanted antlerogenic periosteum (AP) to form pedicle-like, but not antler-like, bony protuberances. To further develop the model and at the same time to use the updated model for the investigation of antler formation, three experiments were carried out in this study. The results showed that (1) antler-like protuberances were successfully induced on the nude mouse heads via subcutaneous co-transplantation of AP and deer skin, and subsequent exposure through wounding of the deer xenografts; (2) deer skin epidermis and its attached half thickness of dermis were sufficient to interact with the AP, and the interactions were capable of transforming adult scalp skin into velvet; (3) the putative initial inductive molecules were primarily derived from the AP cellular layer, rather than fibrous layer; (4) initiation of the ossification center in the avascular cartilage of each mouse "antler" took place via metaplasia, rather than classical endochondral ossification. Further research is required to identify means for effective stimulation of calcification of the "mouse antlers" in order to create the opportunity to investigate antler regeneration using the nude mouse model. Overall, the nude mouse model, once further developed, has the potential to become a powerful tool to study underlying mechanism of antlerogenesis and organogenesis/regeneration in general.


Assuntos
Chifres de Veado/crescimento & desenvolvimento , Modelos Animais , Osteogênese , Animais , Cervos , Camundongos , Camundongos Nus , Transplante Heterólogo
15.
Anat Rec (Hoboken) ; 290(8): 994-1004, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17610257

RESUMO

Deer antlers are the only mammalian appendage to display an annual cycle of full regeneration. The growth phase in antler involves the rapid proliferation of several tissues types, including epidermis, dermis, cartilage, bone, blood vessels, and nerves. Antlers thus provide an excellent model to study the developmental regulation of these tissues. We describe here the identification of two genes, pigment epithelium-derived factor (PEDF) and cyclin-dependent kinase inhibitor 1C (CDKN1C), both of which are known to be involved in cell proliferation and differentiation. These genes were identified as the result of screening an expressed sequence tag database derived from a cDNA library enriched for sequences from the growing antler tip. PEDF mRNA was detected in developing skin, cartilage, and bone during endochondral ossification. PEDF mRNA was not detected within endothelial cells that exhibited positive immunoreactivity to a CD146 antibody. CDKN1C mRNA was expressed by only the immature chondrocytes within the precartilage region. These results suggested that PEDF and CDKN1C are important genes involved in cell proliferation and differentiation during antler growth.


Assuntos
Chifres de Veado/crescimento & desenvolvimento , Inibidor de Quinase Dependente de Ciclina p57/fisiologia , Cervos/fisiologia , Proteínas do Olho/fisiologia , Genes cdc/fisiologia , Fatores de Crescimento Neural/fisiologia , Serpinas/fisiologia , Animais , Chifres de Veado/citologia , Chifres de Veado/fisiologia , Sequência de Bases , Cartilagem/citologia , Cartilagem/crescimento & desenvolvimento , Cartilagem/fisiologia , Diferenciação Celular/genética , Diferenciação Celular/fisiologia , Proliferação de Células , Condrócitos/citologia , Condrócitos/fisiologia , Inibidor de Quinase Dependente de Ciclina p57/genética , DNA/genética , Cervos/genética , Proteínas do Olho/genética , Masculino , Dados de Sequência Molecular , Fatores de Crescimento Neural/genética , RNA Mensageiro/genética , RNA Mensageiro/fisiologia , Serpinas/genética
16.
Ann R Coll Surg Engl ; 89(1): 30-5, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17316517

RESUMO

INTRODUCTION: Surgical care practitioners (SCPs) are an expanding group of professionals, drawn from nursing and the allied health professions. Amongst other functions, SCPs can provide a range of surgical procedures including a 'minor surgical' service. The aim of this study was to audit the volume and outcomes related to the SCP service at St Mary's since its inception. PATIENTS AND METHODS: All prospectively collected data regarding SCP-managed patients between 2001 and 2005 were retrospectively audited. Volume, case mix, waiting times, complications and patient satisfaction were recorded and evaluated. RESULTS: In this 4-year period, the SCP performed 381 minor operative cases (year 1 to year 4: 32, 74, 114 and 161 cases, respectively). These included excision of lipomas, sebaceous cysts and suspicious naevi under local anaesthesia and 7 similar cases under general anaesthetic. There were 11 minor postoperative complications which included 7 wound infections which were all resolved with a short course of oral antibiotics, 2 seromas of which one needed aspiration under local anaesthetic and one minor wound dehiscence which was re-sutured the same day. Overall, 71% were seen within 1 month of referral, 16% within 1-2 months, 3% within 3 months and 10% within 6 months. In addition, 59% were seen and treated within 20 min of their appointed time, 15% within 30-60 min and 24% within 1-2 h. The 3-month patient perspective audit carried out between May and July 2004 included 59 completed patient questionnaires following surgery; 100% were totally satisfied with the care that they received; 98% were happy to see the SCP and 98% documented that they would recommend the SCP to others. CONCLUSIONS: The 4-year period of using an SCP at St Mary's shows that it is feasible and safe for minor operative procedures, that it contributes positively to waiting times and is acceptable to patients.


Assuntos
Corpo Clínico Hospitalar/estatística & dados numéricos , Procedimentos Cirúrgicos Menores/estatística & dados numéricos , Grupos Diagnósticos Relacionados , Estudos de Viabilidade , Humanos , Londres , Auditoria Médica , Neoplasias/cirurgia , Satisfação do Paciente , Estudos Prospectivos , Estudos Retrospectivos , Dermatopatias/cirurgia , Resultado do Tratamento
17.
Cell Tissue Res ; 328(1): 65-75, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17120051

RESUMO

Epimorphic regeneration is the "holy grail" of regenerative medicine. Research aimed at investigating the various models of epimorphic regeneration is essential if a fundamental understanding of the factors underpinning this process are to be established. Deer antlers are the only mammalian appendages that are subject to an annual cycle of epimorphic regeneration. In our previous studies, we have reported that histogenesis of antler regeneration relies on cells resident within the pedicle periosteum (PP). The present study elaborates this finding by means of functional studies involving the deletion of PP. Four yearling and four 2-year-old stags were selected for total PP deletion or partial PP deletion experiments. Of the animals in the total PP deletion group, one showed no signs of antler regeneration throughout the antler growth season. Two showed substantial and one showed marginal delays in antler regeneration (at 34, 20 and 7 days, respectively) compared with the corresponding sham-operated sides. Histological investigation revealed that the delayed antlers were derived from regenerated PP. Unexpectedly, the regenerative capacity of the antler from the total periosteum-deleted pedicles depended on antler length at surgery. Of the four deer that had partial PP deletion, two regenerated antlers exclusively from the left-over PP on the pedicle shafts in the absence of participation from the pedicle bone proper. The combined results from the PP deletion experiments convincingly demonstrate that the cells of the PP are responsible for antler regeneration.


Assuntos
Chifres de Veado/citologia , Chifres de Veado/fisiologia , Periósteo/citologia , Periósteo/fisiologia , Regeneração , Animais , Especificidade de Órgãos
18.
Hist Psychiatry ; 18(71 Pt 3): 275-99, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18175633

RESUMO

Through examination of the career of the psychiatrist August Hoch (1868-1919), this essay challenges two assumptions implicit in histories of US progressive-era psychiatry: that the emergence of Freudian psychoanalysis signalled a devaluation of Kraepelin's contributions and that theoretical and therapeutic eclecticism inhibited psychiatric research. Locating Hoch's guiding principles within the context of Kraepelin's clinical psychiatry, I analyse how Hoch mediated the demands of classification and the dynamic understanding of persons in prosecuting a new kind of clinical research that would not have been possible within either the Kraepelinian or Freudian perspective alone.


Assuntos
Psiquiatria/história , Teoria Psicológica , Pesquisa Biomédica/história , História do Século XIX , História do Século XX , Humanos , Psiquiatria/métodos , Psicanálise/história , Estados Unidos
19.
Anat Rec A Discov Mol Cell Evol Biol ; 288(9): 973-81, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16892427

RESUMO

The process of angiogenesis is of interest because of the significant clinical benefits associated with controlling vascular growth. Within the antler, chondrogenesis and antler elongation are occurring at the rate of 1-2 cm per day and thus blood vessels are growing at this same rapid pace. We demonstrate that the process of angiogenesis in the antler is controlled at various tissue locations. The findings clearly differentiate the spatial location of the stem cells that drive chondrogenesis from the proliferation process driving the angiogenesis. Vessels within the lateral dermis contained BrdU-positive cells, suggesting that these vessels were elongating. Within the precartilage region, proliferating vessels were detected in bundles of complex structure evenly distributed throughout this tissue layer. The support cells within these bundles of vessels were detected by staining with alpha-smooth muscle actin, while the endothelial cells were negative. Additionally, the alpha-smooth muscle actin staining was found in association with the cartilage cells of the antler. The marked proliferation of the vascular associated cells in the precartilage region identified this area as a major region of vascular growth in the antler. We propose that within the precartilage region, the most likely mechanisms to explain the observed vascular morphology are that of vascular extension of the existing vessels and intussusceptive angiogenesis or sprouting to generate the small bundles of vessels. Wiley-Liss, Inc.


Assuntos
Chifres de Veado/irrigação sanguínea , Chifres de Veado/crescimento & desenvolvimento , Vasos Sanguíneos/crescimento & desenvolvimento , Cervos/fisiologia , Neovascularização Fisiológica/fisiologia , Actinas/metabolismo , Animais , Biomarcadores/metabolismo , Vasos Sanguíneos/citologia , Vasos Sanguíneos/metabolismo , Cartilagem/citologia , Cartilagem/crescimento & desenvolvimento , Cartilagem/metabolismo , Proliferação de Células , Condrócitos/citologia , Condrócitos/metabolismo , Técnicas Imunoenzimáticas
20.
Mem Cognit ; 33(3): 471-8, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16156182

RESUMO

Mathematical solutions to textbook word problems are correlated with semantic relations between the objects described in the problem texts. In particular, division problems usually involve functionally related objects (e.g., tulips-vases) and rarely involve categorically related objects (e.g., tulips-daisies). We examined whether middle school, high school, and college students use object relations when they solve division word problems (WP) or perform the less familiar task of representing verbal statements with algebraic equations (EQ). Both tasks involved multiplicative comparison statements with either categorically or functionally related objects (e.g., "four times as many cupcakes [commuters] as brownies [automobiles]"). Object relations affected the frequency of correct solutions in the WP task but not in the EQ task. In the latter task, object relations did affect the structure of nonalgebraic equation errors. We argue that students use object relations as "semantic cues" when they engage in the sense-making activity of mathematical modeling.


Assuntos
Sinais (Psicologia) , Modelos Teóricos , Resolução de Problemas , Semântica , Vocabulário , Adolescente , Humanos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...