RESUMO
The influence of smoking on cerebral hemodynamics and biochemical blood indices has been studied in 50 male patients with chronic insufficiency of brain circulation (CIBC), aged 40-50 years, divided into 2 groups: smoking (n=26) and nonsmoking (n=24). Smoking was shown to play a substantial role in the development of discirculatory encephalopathy with atrophic brain changes, causing metabolic disturbances (a shift of acid-basic balance towards acidosis) and microcirculation disorders due to altered cerebrovascular reactivity. These alterations develop previously to hemodynamically significant atherosclerotic arteries lesion and emerge irrespective of the presence of atherosclerotic vascular changes, atherogenic shifts of lipid metabolism, disturbances of free-radical processes and platelet aggregation.
Assuntos
Encéfalo/irrigação sanguínea , Encéfalo/metabolismo , Arteriosclerose Intracraniana/etiologia , Arteriosclerose Intracraniana/metabolismo , Arteriosclerose Intracraniana/fisiopatologia , Peroxidação de Lipídeos/fisiologia , Lipoproteínas/metabolismo , Fumar/efeitos adversos , Circulação Cerebrovascular/fisiologia , Hemodinâmica/fisiologia , HumanosRESUMO
Changes of spontaneous unit activity in the lateral vestibular nucleus of the rat following 5-, 10- and 15-day vibration (60 Hz, 2 hrs. Daily), were studied. Averaged histogramz and autocorrelograms were analysed following computerized interspike intervals. The data obtained revealed a variety of the unit activity in its direct or mediated effects exerted through several structures of the central nervous system.