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1.
Fiziol Zh (1994) ; 54(6): 87-99, 2008.
Artigo em Russo | MEDLINE | ID: mdl-19227245

RESUMO

We have analyzed the recent data about Toll-like receptors (TLRs) that play the most important role in host immune defense. TLRs involved in induction and modulation of innate and acquired immunity as the integrators of their reactions. Genetic disorders of TLRs or their signaling pathways components were noticed with different pathologies. TLRs are the ideal molecular target for the therapy of many diseases including inflammatory, autoimmune, allergic and tumor diseases.


Assuntos
Imunidade Inata/fisiologia , Receptores Toll-Like/fisiologia , Animais , Doença/etiologia , Humanos , Imunidade Inata/efeitos dos fármacos , Imunidade Inata/genética , Ligantes , Receptores Toll-Like/genética , Receptores Toll-Like/metabolismo
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