RESUMO
In order to clarify an index which could be used as proof of the presence of hydroxyl radical, a new standard isomer distribution ratio of phenols formed from aromatic hydroxylation with [(4-bromophenyl)diazenyl](phenyl)methyl hydroperoxide 4, which is a stable source of hydroxyl radical, under a new appropriate photolysis condition in the presence or absence of benzoquinones is reported. We also demonstrated the strong electrophilic properties of hydroxyl radical in reference to earlier results of electron density calculations.
Assuntos
Radical Hidroxila/química , Cromatografia Gasosa , FotoquímicaRESUMO
The synthesis and biological activity of novel 1-phenylsulfonyl-4- phenylsulfonylaminopyrrolidine analogues are described. All compounds were produced through modification of the substituent formally corresponding to the 1,3-dioxane ring system and the omega-octenol side chain of thromboxane A(2) (TXA(2)), in reference to the structure of Daltroban. Several compounds were found to be potent TXA(2) receptor antagonists. Compound 51a was the most effective inhibitor of 9,11-epoxymethano PGH(2) (U-46619)-induced rat aortic strip contraction (IC(50)=0.48 nM).