[Malonaldehyde and tumor necrosis factor-alpha as indicators of intoxication syndrome in erysipelatous inflammation].

The aim of the investigation was to study the implication of infectious endotoxicosis in the pathogenesis of erysipelas, by measuring the level of malondialdehyde and the proinflammatory cytokine tumor necrosis factor-a (TNF-a) depending on the stage, severity, pattern of the disease, and possible complications. Fifty-six patients with erysipelas were followed up. Their blood level of malondialdehyde and TNF-a was determined at the height of the disease and during the reduction of clinical symptoms, and early convalescence. There was an increase in the study indicators, which depended on the period and severity of the disease and the presence of comorbidity and complications. The changes found in the study indicators characterize the development of intoxication syndrome in erysipelas and make possible their use to evaluate the severity of the diseases, the presence of complications, and the completeness of recovery.

[Evaluation of the endogenous intoxication syndrome in food toxic infections].

To study the endogenous intoxication syndrome in patients with food toxic infections is essential in revealing the pathogenetic mechanisms underlying this disease. For this, the authors measured the level of low and average molecular weight, as well as their protein component--oligopeptides in plasma, red blood cells, and urine in the course of the disease. There were increased levels of the study parameters, which depended on the stage and degree of a pathological process. The determination of the level of low and average molecular weight and oligopeptides in plasma, red blood cells, and urine may serve as a marker of the intoxication syndrome; the level of the study parameters may be used as additional criteria for the severity of the process, the prediction of disease development and comorbidity, and as a criterion for recovery completeness.

[T-lymphocyte subpopulations and tumor necrosis factor-alpha in patients with acute Flexner's dysentery]. / Subpopuliatsii T-limfotsitov i factor nekroza opukholi alpha u bol'nykh ostroi dizenteriei Fleksnera..

In 41 patients aged 24-63 years with acute Flexner's dysentery T-lymphocyte subpopulations CD-3, CD-4, CD-8, IRI and the content of tumor necrosis factor alpha (TNF-alpha) in the blood serum were detected. The suppression of T-cell mediated immunity on account of the presence of CD-4 with decreased immunoregulatory index and an increased content of TNF-alpha were established. Changes in T-cell mediated immunity and TNF-alpha depended on the period and the severity of the diseases.

[Malondialdehyde and ceruloplasmin levels in plasma of patients with alimentary toxic infection]. / Soderzhanie malonovogo dial'degida i tseruloplazmina v plazme krovi u bol'nykh s pishchevymi toksikoinfektsiiami.

The content of malonic dialdehyde and of ceruloplasmin in blood plasma was studied, as an indicator of the prooxidant-antioxidant system, in 84 patients, aged 21 to 63, with alimentary toxicoinfection. A higher level of malonic dialdehyde and a lower level of ceruloplasmin were detected, which depended on a disease stage and on a severity of the clinical course and pathologic progression.

[Some aspects of evaluating endogenous intoxication in patients with acute dysentery]. / Nekotorye voprosy otsenki éndogennoi intoksikatsii u bol'nykh ostroi dizenteriei.

AIM: To evaluate endogenic intoxication in patients with acute dysentery (AD) by examination of substances of low and medium molecular mass (LM and MM) in different body media. MATERIAL AND METHODS: 122 patients with acute dysentery were tested for LM and MM substances by M. Ya. Malakhova in plasm, red cells, urine in the course of the disease. RESULTS: Concentration of LM and MM substances in patients with AD was much higher compared to healthy subjects in all the examined fluids at the height of the disease. In decline of clinical symptoms the studied concentrations diminished, in early convalescence the substances were at normal levels in red cells and urine being higher in plasm. Maximal changes of the LM and MM substances' concentrations were noted in a severe course of AD. CONCLUSION: In acute bacterial dysentery concentration of LM and MM substances in blood plasm, red cells and urine depend on the period of the disease course and AD severity. This may indicate the degree of endogenic intoxication in these patients.