1.
Infect Immun
; 19(2): 486-92, 1978 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-305416
RESUMO
Infection of susceptible strains of mice with Friend leukemia virus (FLV) results in a profound depression of cell-mediated immunity as assessed by lymphocyte-mediated cytotoxicity. This depression occurs early in the disease, before the onset of splenomegaly, and is associated with a decline in the susceptibility of splenocytes from FLV-infected mice to lysis by anti-Thy-1. 2 serum and complement. Treatment of splenocytes from FLV-infected mice with neuraminidase restores, in large part, their susceptibility to anti-Thy-1.2 serum as well as their cytolytic capacity. These studies suggest that one early immunosuppressive consequence of infection with FLV involves alteration of the effector T-lymphocyte cell surface.
Assuntos
Vírus da Leucemia Murina de Friend/imunologia , Terapia de Imunossupressão , Leucemia Experimental/imunologia , Linfócitos/imunologia , Neuraminidase/uso terapêutico , Baço/imunologia , Animais , Soro Antilinfocitário , Proteínas do Sistema Complemento , Testes Imunológicos de Citotoxicidade , Feminino , Leucemia Experimental/tratamento farmacológico , Camundongos , Camundongos Endogâmicos , Linfócitos T/imunologia
2.
Adv Exp Med Biol
; 73 Pt B: 305-18, 1976.
Artigo
em Inglês
| MEDLINE
| ID: mdl-793339