Prevalence of human papillomavirus infection among women at a gynaecological clinic in Tlemcen, Algeria.

High-risk human papillomavirus (HR-HPV) is recognized as the etiologic agent responsible for cervical cancer, ranking as the second most prevalent cancer among women in Algeria with an incidence rate of 10.4 per 100,000. The primary aim of this study was to conduct a preliminary prospective investigation into the detection of HR-HPV infections in Tlemcen, Algeria, where screening is exclusively based on cytology. A total of 130 cervical swabs were analysed in this study. HPV detection was performed utilizing the Cobas® 4800 test, incorporating polymerase chain reaction (PCR) for individual genotyping of HPV-16 and HPV-18, as well as pooled detection of 12 other commonly occurring HPVs. The findings revealed that out of the 130 samples, 28 tested positive for HR-HPV, resulting in a prevalence rate of 21.5%. Among these cases, five infections demonstrated the coexistence of HPV16 with other HR-HPV genotypes. The prevalence of HPV16 infections was determined to be 28.6% (8/28), whereas 68% of infections (19/28) were attributed to other HR-HPV genotypes. These observations indicate that HPV16 was not the prevailing genotype. Consequently, these results underscore the necessity for a larger-scale study with an expanded sample size encompassing cytology and HPV testing. Such an investigation would be invaluable in facilitating the development of a national prevention program to effectively control cervical cancer.

Erratum to: colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years.

[This corrects the article DOI: 10.1111/agc.123.].

Colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years.

Aims: The objective of this work is to evaluate the epidemiological profile of colorectal cancers, histologically proven over a 5-year period (2012-2016) in the Tlemcen region. Methods: A retrospective study of 581 cases of colorectal cancer collected at the epidemiology department of the University Hospital Center (UHC) of Tlemcen between January 2012 and December 2016 was performed. Epidemiological data were processed using SPSS version 25 and Microsoft Excel 2010. Results: The epidemiological profile has shown that colorectal cancer in our region ranks 3rd in both sexes. There were 322 men (55.4%) affected compared to 259 women (44.6%) with a sex ratio of 1.2. A predominance of males is noted in 50-60 age group, while for the female sex, the dominance is between 60-70 years old. The mean age of CRC occurrence was 60±13 years, with an extremity ranging from16 to 90. A significantly higher rate was recorded for rectal cancer (43.7%) followed by sigmoid colon (5.7%). Variable rates were recorded during the 5 years with a peak in 2014 (27.9%). Conclusion: Regular analysis of these data, if supplemented with additional data on diagnostic modalities like circular RNA diagnostic, will contribute to the assessment of the impact over time of public policies on nationally organized CRC screening.

Retrospective epidemiological study on stomach cancer in a region of western Algeria: about 394 cases between 2011 and 2015.

PURPOSE: Stomach cancer is a major global health problem; it is one of the ten most common cancers with poor survival, and its incidence is characterized by wide variation. The aim of this work is to carry out a retrospective epidemiological study on gastric cancer in the wilaya of Tlemcen (West Algeria) over a period of 5 years (2011-2015). METHODS: The data set was provided by the cancer registry of the Tlemcen wilaya. The statistical analysis was performed using software SPSS.21. RESULTS: During this period, 394 cases of gastric cancers were collected, including 199 patients with gastric adenocarcinoma (50.50%); gastric cancer was ranked in 5th rank of the ten most answered cancers in the wilaya. The average age of the patients was 60.5 ±  14.208 years (60.618 ±  13.556 men, 56.654 ±  14.8761 women) with an extremity ranging from 18 to 91 years. A predominance of men has been observed with 60.4% against 39.6% of women, with a sex ratio of 1.5 and a significant difference between the two sexes (p = 0.08). Patients over 50 years of age represented the predominant age group (73.4%). The tumor topography was antropyloric in 6.09% of the cases, and the vast majority of the diagnosed cases was in the local stage (17.01%). CONCLUSION: Stomach cancer remains one of the top ten cancers in the Tlemcen willaya, so extensive research on the risk factors for gastric cancer remains important to plan effective preventive and curative strategies to reduce this burden.

[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population]. / Le génotypage d'ADN d'HPV : une étude de cancers ano-génitaux, de cancers des VADS et de cancers cutanés dans la population de l'ouest algérien. Détection d'HPV dans différents cancers dans la population de l'ouest algérien.

OBJECTIVES: To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014. MATERIAL AND METHODS: Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was provided from 39 anogenital cancers, 10 head and neck cancers and 36 skin cancers. The viral DNA was detected using the INNO-LiPA HPV Genotyping Extra(®) kit. RESULTS: The prevalence of HPV was 100% in cervical cancers, 40% in vaginal cancers, 17% in vulvar cancers, 33% in anal cancers, 0% in tonsil and larynx cancers and 6.4% in skin squamous cell carcinoma. In cervical cancers, the most prevalent genotypes were HPV16 (52%) and HPV18 (12%) as single infection. CONCLUSION: The overall results agree partially with literature. Extensive research is necessary to promote HPV vaccine to reduce in particular the burden of cervical cancer in Algeria.