RESUMO
The level of complications in patients with the mandibular fractures does not have a tendency to the decline. A research purposes is a study of the basic laws of immunological reactions and possibility of optimizing processes osteogenesis by drugs-cytokines at patients with the mandibular fractures with delayed consolidation of bone tissue. 46 patients with the mandibular fractures were observed. The maintenance of cytokines IL - 1ß, TNF - α, IL - 4, SICAM-1 in the blood serum, IgA, IgM, IgG in a mouth liquid was probed. It is set that in pathogenesis of delayed consolidation a basic role is played by changes reactivity of organism, which realized in three directions: immunodeficit of humoral immunity, immunodepression of cellular factors of defence, disbalance in functioning of the cytokines system. It is necessary to count the levels of products SICAM-1 and cytokine IL-1ß in the blood serum by the diagnostic criteria of bone repair features at patients with the mandibular fractures: development of delayed consolidation of mandibular fragments is accompanied the increase of their parameters at the control group more than in 2 and in 15 times (668,2±10,3 pg/ml and 363,4 ±6,6 pg/ml relatively). Includding in the complex treatment of the mandibular fractures of immunomodulator Ronkoleukin showed clinico-immunological efficiency for the patients with impaired bone repair.
Assuntos
Regeneração Óssea/imunologia , Fraturas Mandibulares/tratamento farmacológico , Fraturas Mandibulares/imunologia , Osteogênese/imunologia , Adulto , Regeneração Óssea/efeitos dos fármacos , Feminino , Humanos , Imunoglobulina A/imunologia , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Fatores Imunológicos/administração & dosagem , Molécula 1 de Adesão Intercelular/sangue , Molécula 1 de Adesão Intercelular/imunologia , Interleucina-1beta/sangue , Interleucina-1beta/imunologia , Interleucina-4/sangue , Interleucina-4/imunologia , Masculino , Fraturas Mandibulares/sangue , Osteogênese/efeitos dos fármacos , Fator de Necrose Tumoral alfa/sangue , Fator de Necrose Tumoral alfa/imunologiaRESUMO
The study based on immunological and epidemiological evaluation of large groups of population has revealed the factors responsible principally for periodontitis pattern. They are: 1) microbial and tissue sensitization, 2) immune defences, 3) disturbed microcirculation in periodontal tissues. In view of various causes underlying periodontitis it is advisable to take them into consideration when evaluating diagnostic data and deciding on indications for immunocorrective therapy.
