RESUMO
It has been shown that a single exposure to 171 MHz electromagnetic field with 180 V/m electric field strength and 0.04 mW/kg specific absorption rate significantly alters the Na+/Ca2+ exchange in the isolated rat heart. It is assumed that enhancement of the Na+/Ca2+ exchange towards removing Ca2+ from the cardiomyocytes electromagnetic field exposure is a result of Ca2+ extraction from the sarcoplasmic reticulum and the increase of its intracellular level.
Assuntos
Campos Eletromagnéticos , Coração/efeitos da radiação , Miócitos Cardíacos/efeitos da radiação , Ondas de Rádio , Animais , Cálcio/metabolismo , Miócitos Cardíacos/metabolismo , Técnicas de Cultura de Órgãos , Ratos , Retículo Sarcoplasmático/metabolismo , Retículo Sarcoplasmático/efeitos da radiação , Sódio/metabolismoRESUMO
The results of analysis of the literature publications suggest the necessity of experimental studies aimed at investigation of modulating effect of low-frequency magnetic fields on endocrine organs. The present study was carried out using 200 outbred white male rats (body weight 200-220 g). Corticosterone was measured in blood sera following the application of a low-frequency magnetic field (20 and 53 Hz with induction from 0.4 to 6 mT) generated by a Mini-Expert-T apparatus for induction magnetic therapy during 30 minutes. It was shown that the application of the alternating magnetic field to the adrenal region of the rats in the selected frequency and induction ranges caused a significant increase in the serum corticosterone levels. The results of the present study on the hormonal activity of rat adrenals give reason to consider the influence of the alternating magnetic fields as being modulatory. Analysis of the data thus obtained has demonstrated the non-linear dependence of glucocorticoid activity of the rat adrenal glands on the induction strength of the alternating magnetic field.
Assuntos
Glândulas Suprarrenais/metabolismo , Corticosterona/sangue , Campos Magnéticos , Animais , Masculino , Ratos , Fatores de TempoRESUMO
UV-light and dexamethasone influence on functional properties of lymphocytes and neutrophils of peripherical donors' blood was studied. An increase of phagocytic activity of neutrophils was observed after their incubation with photomodified lymphocytes. It was found that UV-irradiation of lymphocytes activated synthesis of interleukines 1beta and 2. Dexamethasone presence in lymphocyte suspension inhibited the synthesis of the studied cytokines, especially by the incubation with photomodified cells. It was shown by the method of fluorescent labels that UV-irradiation improved interaction between dexamethasone and cell membrane.
Assuntos
Dexametasona/farmacologia , Glucocorticoides/farmacologia , Linfócitos/efeitos dos fármacos , Linfócitos/efeitos da radiação , Neutrófilos/efeitos dos fármacos , Neutrófilos/efeitos da radiação , Raios Ultravioleta , Adulto , Doadores de Sangue , Membrana Celular/efeitos dos fármacos , Citocinas/biossíntese , Interpretação Estatística de Dados , Humanos , Técnicas In Vitro , Interleucina-1/biossíntese , Interleucina-2/biossíntese , Peroxidação de Lipídeos , Medições Luminescentes , Linfócitos/imunologia , Linfócitos/metabolismo , Masculino , Pessoa de Meia-Idade , Neutrófilos/imunologia , Neutrófilos/metabolismo , Fagocitose , Doses de Radiação , Fatores de TempoRESUMO
To conduct large-scale medical examinations of the population with a view to detecting cardiovascular affections an experimental automated complex has been set up. The program of the examination to be instituted is largely drawn up conformable to recommendation of the WHO. In the complex are envisaged collection and registration of the data on the patient, biochemical analyses of the blood and urine, compilation of the case-history, anthropometric measurements and determination of the arterial blood pressure, ECG recording, veloergometric load test measurements, along with spirometric ones and the measurement of the subcutaneous fat layer thickness. The processing of the information obtained is done at the computation under "off-line" conditions.
