[The choice of surgical strategy for patients with obstructive jaundice and high risk of multi-organ insufficiency syndrome]. / Vybor khirurgicheskoi taktiki u bol'nykh s obturatsionnoi zheltukhoi i vysokim riskov vozniknoveniia poliorgannoi nedostatochnosti.

We examined 128 patients with obstructive jaundice of non-tumoral genesis that were surgically treated. We studied the immune status and plasma concentration of interleukine-8 in pre-operation period in order to predict the polyorganic insufficiency (PI) risk. Depending on the results obtained, patients were divided into groups defined as those of low or high risk of PI. This permitted to apply differentiated treatment with the use of multi-grade surgical intervention and extracorporal detoxication. This contributed to decrease of post-operative complications rate and mortality.

[The stress mechanisms of mammalian adaptation to an elevated content of radionuclides in the environment]. / Stressovye mekhanizmy adaptatsii mlekopitaiushchikh k povyshennomu soderzhaniiu radionuklidov v srede.

Analysis of populations of rodents and their stability in radioactively contaminated territories (East Ural radioactive track and regions contaminated after the Chernobyl Nuclear Power Plant accident) suggests that non-specific stability due to the stress mechanisms plays an important role in adaptation of the animals to the life in these regions. According to the published data, the elevated radioresistance of animals in these regions appeared to be due to increased non-specific stability formed by the stress mechanisms.

[The immune protection of the gastroduodenal area after the surgical treatment of duodenal peptic ulcer]. / Immunnaia zashchita gastroduodenal'noi zony posle khirurgicheskogo lecheniia iazvennoi bolezni dvenadtsatiperstnoi kishki.

The complex study of the indices of local immune and natural resistance in the parietal mucus of the gastroduodenal zone and general immunity in 174 patients with duodenal ulcer disease before and after surgical treatment was performed. Pronounced suppression of local immunity, presence of autoimmune processes having influence on its indices were noted. After the organ-preserving operations with an ulcer excision, the immune indices restored more rapidly than after gastric resection and vagotomy without an ulcer excision.