FEATURES OF ANATOMICAL LESIONS OF CORONARY ARTERIES DEPENDING ON THE LEVELS OF ST2 AND TROPONIN I IN BLOOD PLASMA IN PATIENTS WITH NSTEMI.

The aim of the study is to evaluate the dependence of associations of ST2, and Troponin I level on the nature of the anatomical lesion of the coronary arteries. We examined 200 patients with NSTEMI aged 38 to 80 years, who were urgently hospitalized in the Vinnytsya Regional Clinical Center of Cardiovascular Pathology. All patients underwent laboratory testing of ST2, and Troponin I level in plasma by enzyme-linked immunosorbent assay on the first day of hospitalization before coronary angiography. In the association of relatively high levels of ST2 and relatively high levels of Troponin I, there is a positive correlation between the degree of coronary arteries damage, while in the association of relatively low levels of ST2 and Troponin I, severe stenotic coronary arteries lesions can be ruled out. Determining the associations of ST2 and Troponin I before coronary angiography allows to predict the degree of stenotic lesions of the coronary arteries and to determine the expected intervention strategy in patients with NSTEMI.

FEATURES OF THE CORONARY ARTERIES ANATOMICAL LESIONS IN NSTEMI PATIENTS DEPENDING ON THE ASSOCIATION WITH THE INITIAL CLINICAL CHARACTERISTICS.

The aim of the study is to determine the nature of the anatomical lesion of the coronary arteries in NSTEMI depending on different clinical characteristics. We examined 156 patients with NSTEMI aged 38 to 80 years, who were urgently hospitalized in the Vinnytsya Regional Clinical Center of Cardiovascular Pathology. The results of the study showed no gender differences in coronary artery disease. However, an association has been established with a number of clinical and instrumental parameters, including Troponin I levels, ECG changes such as ST depression, smoking status, age less than 62 years, concomitant type II diabetes, and a GRACE score of ≤ 126. Conclusions. 1. There were no significant gender differences in the nature of the anatomical lesion of the coronary arteries in the general cohort of NSTEMI patients aged 38 to 80 years. 2. In patients with NSTEMI 2- or 3-vascular lesions of the coronary arteries should be expected in the case of registration of significant depression of the ST segment on the ECG (≥ 3 mm) and relatively high levels of troponin I in plasma (≥ 6 ng/ml) at baseline, as well as in if there is such a risk factor as smoking and its history for more than 26 years. 3. Relatively intact coronary arteries should be expected in younger patients (≤ 62 years), in patients with type II diabetes mellitus, as well as in the case of relatively low plasma troponin I levels (≤ 6 ng/ml) and low score on the GRACE score stratification (≤ 126 points) at the initial examination of patients.