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1.
Med. intensiva (Madr., Ed. impr.) ; 45(4): 234-342, Mayo 2021. ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-222217

RESUMO

Los cuidados intensivos orientados a la donación (CIOD) se definen como el inicio o la continuación de medidas de soporte vital, incluyendo la ventilación mecánica, en pacientes con lesión cerebral catastrófica y alta probabilidad de evolucionar a muerte encefálica, en los que se ha descartado cualquier tipo de tratamiento. Los CIOD incorporan la opción de la donación de órganos permitiendo un enfoque holístico en los cuidados al final de la vida coherente con los deseos y valores del paciente. Si el paciente no evoluciona a muerte encefálica, se deben retirar las medidas de soporte vital valorando la donación en asistolia controlada. Los CIOD respetan el marco ético y legal y contribuyen a aumentar las probabilidades de los pacientes de acceder a la terapia de trasplante, generando salud, incrementando la donación en un 24% con una media de 2,3 órganos trasplantados por donante y contribuyendo a la sostenibilidad del sistema sanitario. Estas recomendaciones ONT-SEMICYUC proporcionan una guía para facilitar una práctica armonizada de los CIOD en las UCI españolas. (AU)


Intensive care to facilitate organ donation (ICOD) is defined as the initiation or continuation of life-sustaining measures, such as mechanical ventilation, in patients with a devastating brain injury with high probability of evolving to brain death and in whom curative treatment has been completely dismissed and considered futile. ICOD incorporates the option to organ donation allowing a holistic approach to end-of-life care, consistent with the patients wills and values. Should the patient not evolve to brain death, life-supportive treatment must be withdrawal and controlled asystolia donation could be evaluated. ICOD is a legitimate practice, within the ethical and legal regulations that contributes increasing the accessibility of patients to transplantation, promoting health by increasing deceased donation by 24%, and with a mean of 2.3 organs transplanted per donor, and collaborating with the sustainability of health-care system. This ONT-SEMICYUC recommendations provide a guide to facilitate an ICOD harmonized practice in spanish ICUs. (AU)


Assuntos
Humanos , Obtenção de Tecidos e Órgãos , Morte Encefálica , Transplantes
2.
Med Intensiva (Engl Ed) ; 45(4): 234-242, 2021 May.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31740045

RESUMO

Intensive care to facilitate organ donation (ICOD) is defined as the initiation or continuation of life-sustaining measures, such as mechanical ventilation, in patients with a devastating brain injury with high probability of evolving to brain death and in whom curative treatment has been completely dismissed and considered futile. ICOD incorporates the option to organ donation allowing a holistic approach to end-of-life care, consistent with the patients wills and values. Should the patient not evolve to brain death, life-supportive treatment must be withdrawal and controlled asystolia donation could be evaluated. ICOD is a legitimate practice, within the ethical and legal regulations that contributes increasing the accessibility of patients to transplantation, promoting health by increasing deceased donation by 24%, and with a mean of 2.3 organs transplanted per donor, and collaborating with the sustainability of health-care system. This ONT-SEMICYUC recommendations provide a guide to facilitate an ICOD harmonized practice in spanish ICUs.

3.
Med. intensiva (Madr., Ed. impr.) ; 43(6): 352-361, ago.-sept. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-183254

RESUMO

Objective: To determine factors related to limitations on life support within 48h of intensive care unit (ICU) admission. Study design: Prospective multicenter study. Setting: Eleven ICUs. Patients: All patients who died and/or had limitations on life support after ICU admission during a four-month period. Variables: Patient characteristics, hospital characteristics, characteristics of limitations on life support. Time-to-first-limitation was classified as early (<48h of admission) or late (≥48h). We performed univariate, multivariate analyses and CHAID (chi-square automatic interaction detection) analysis of variables associated with limitation of life support within 48h of ICU admission. Results: 3335 patients were admitted; 326 (9.8%) had limitations on life support. A total of 344 patients died; 247 (71.8%) had limitations on life support (range among centers, 58.6%-84.2%). The median (p25-p75) time from admission to initial limitation was 2 (0-7) days. CHAID analysis found that the modified Rankin score was the variable most closely related with early limitations. Among patients with Rankin >2, early limitations were implemented in 71.7% (OR=2.5; 95% CI: 1.5-4.4) and lung disease was the variable most strongly associated with early limitations (OR=12.29; 95% CI: 1.63-255.91). Among patients with Rankin ≤2, 48.8% had early limitations; patients admitted after emergency surgery had the highest rate of early limitations (66.7%; OR=2.4; 95% CI: 1.1-5.5). Conclusion: Limitations on life support are common, but the practice varies. Quality of life has the greatest impact on decisions to limit life support within 48h of admission


Objetivo: Determinar los factores relacionados con la limitación del tratamiento de soporte vital (LTSV) en las primeras 48h de ingreso en Unidades de Cuidados Intensivos (UCI). Diseño: Multicéntrico prospectivo. Ámbito: Once UCI. Pacientes: Pacientes fallecidos y/o en los que se aplicó LTSV durante 4 meses. Variables de interés: Características de pacientes, hospital y LTSV. Se definió LTSV precoz la que ocurría en las primeras 48h de ingreso y tardía >48h. Realizamos análisis univariado, multivariado y árbol de decisión chi-square automatic interaction detection (CHAID) con las variables asociadas con LTSV en las primeras 48h. Resultados: Incluidos 3.335 pacientes, en 326 (9,8%) se aplicó LTSV y 344 fallecieron; de estos 247 (71,8%) se limitaron (variabilidad interhospitalaria: 58,6-84,2%). La mediana de tiempo (p25-p75) entre el ingreso y la LTSV inicial fue de 2 (0-7) días. El análisis CHAID evidenció que la escala de Rankin modificada fue la variable más estrechamente relacionada con la limitación precoz. Entre los pacientes con Rankin>2 la LTSV precoz se realizó en el 71,7% (OR=2,5; IC 95%: 1,5-4,4) y la enfermedad pulmonar fue la variable más relacionada con la LTSV precoz (OR=12,29; IC 95%: 1,63-255,91). Entre los pacientes con Rankin≤2, la LTSV precoz ocurrió en el 48,8% siendo los pacientes con cirugía urgente aquellos con mayor LTSV precoz (66,7%; OR=2,4; IC 95%: 1,1-5,5). Conclusión: La LTSV es común pero la práctica es variable. La calidad de vida es la variable que mayor impacto tiene sobre la LTSV en las primeras 48h del ingreso en la UCI


Assuntos
Humanos , Pessoa de Meia-Idade , Idoso , Suporte Vital Cardíaco Avançado/métodos , Unidades de Terapia Intensiva , Estudos Prospectivos , Análise Multivariada , Qualidade de Vida , Cuidados Paliativos na Terminalidade da Vida , Modelos Logísticos , Algoritmos
4.
Med Intensiva (Engl Ed) ; 43(6): 352-361, 2019.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29747939

RESUMO

OBJECTIVE: To determine factors related to limitations on life support within 48h of intensive care unit (ICU) admission. STUDY DESIGN: Prospective multicenter study. SETTING: Eleven ICUs. PATIENTS: All patients who died and/or had limitations on life support after ICU admission during a four-month period. VARIABLES: Patient characteristics, hospital characteristics, characteristics of limitations on life support. Time-to-first-limitation was classified as early (<48h of admission) or late (≥48h). We performed univariate, multivariate analyses and CHAID (chi-square automatic interaction detection) analysis of variables associated with limitation of life support within 48h of ICU admission. RESULTS: 3335 patients were admitted; 326 (9.8%) had limitations on life support. A total of 344 patients died; 247 (71.8%) had limitations on life support (range among centers, 58.6%-84.2%). The median (p25-p75) time from admission to initial limitation was 2 (0-7) days. CHAID analysis found that the modified Rankin score was the variable most closely related with early limitations. Among patients with Rankin >2, early limitations were implemented in 71.7% (OR=2.5; 95% CI: 1.5-4.4) and lung disease was the variable most strongly associated with early limitations (OR=12.29; 95% CI: 1.63-255.91). Among patients with Rankin ≤2, 48.8% had early limitations; patients admitted after emergency surgery had the highest rate of early limitations (66.7%; OR=2.4; 95% CI: 1.1-5.5). CONCLUSION: Limitations on life support are common, but the practice varies. Quality of life has the greatest impact on decisions to limit life support within 48h of admission.


Assuntos
Cuidados Críticos/normas , Cuidados para Prolongar a Vida/normas , Suspensão de Tratamento , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Admissão do Paciente , Estudos Prospectivos , Fatores de Tempo
5.
Transplant Proc ; 47(8): 2314-7, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26518914

RESUMO

OBJECTIVE: The objective of this study was to describe tissue procurement activity performed during 10 years (2004-2014) by trained medical students in a large university hospital. METHODS: In this study, third to sixth year medical students were trained as in-hospital Tissue Coordinators (Tc) to perform tissue procurement activity on a 24/7 schedule supervised by an on-call senior Transplant Coordinator (sTC) in a large university hospital. Tc duty consisted of detection, initial evaluation of all hospital deaths, donor's family approach for tissue donation, and retrieval logistics organization, including corneal tissue retrieval after training and certification. They also assist sTC in organ procurement activity. RESULTS: A total of 18,931 deaths were prospectively evaluated, 79% of whom (n = 14,879) presented medical contraindications for tissue donation. Of the remaining 4052 (21%) potential tissue donors (PTD), 2522 (62%) were not converted into real donors, mostly due to family refusal (66%; n = 1650) followed by detection system failure and other logistical issues (34%; n = 872). A total of 2814 corneal units, 225 skin donations, 327 muscleskeletal tissue donations, 91 blood vessels donations, and 177 heart valve donations were obtained from the remaining 1530 (38%) real donors. Tissue potentiality increased from 19% to 43% throughout the study period as a consequence of the fluctuating acceptance criteria used by tissue banks depending on tissue demand. CONCLUSIONS: The tissue donation program performed by trained students was successful in achieving a high and sustainable tissue donation rate in a large university hospital.


Assuntos
Educação de Graduação em Medicina , Estudantes de Medicina , Obtenção de Tecidos e Órgãos , Adulto , Criança , Família , Feminino , Hospitais Universitários , Humanos , Masculino , Espanha , Bancos de Tecidos , Doadores de Tecidos
6.
Anaesthesia ; 70(10): 1130-9, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26040194

RESUMO

We conducted a multicentre study of 1844 patients from 42 Spanish intensive care units, and analysed the clinical characteristics of brain death, the use of ancillary testing, and the clinical decisions taken after the diagnosis of brain death. The main cause of brain death was intracerebral haemorrhage (769/1844, 42%), followed by traumatic brain injury (343/1844, 19%) and subarachnoid haemorrhage (257/1844, 14%). The diagnosis of brain death was made rapidly (50% in the first 24 h). Of those patients who went on to die, the Glasgow Coma Scale on admission was ≤ 8/15 in 1146/1261 (91%) of patients with intracerebral haemorrhage, traumatic brain injury or anoxic encephalopathy; the Hunt and Hess Scale was 4-5 in 207/251 (83%) of patients following subarachnoid haemorrhage; and the National Institutes of Health Stroke Scale was ≥ 15 in 114/129 (89%) of patients with strokes. Brain death was diagnosed exclusively by clinical examination in 92/1844 (5%) of cases. Electroencephalography was the most frequently used ancillary test (1303/1752, 70.7%), followed by transcranial Doppler (652/1752, 37%). Organ donation took place in 70% of patients (1291/1844), with medical unsuitability (267/553, 48%) and family refusal (244/553, 13%) the main reasons for loss of potential donors. All life-sustaining measures were withdrawn in 413/553 of non-donors (75%).


Assuntos
Morte Encefálica/diagnóstico , Cuidados Críticos/organização & administração , Obtenção de Tecidos e Órgãos/organização & administração , Adulto , Idoso , Feminino , Escala de Coma de Glasgow , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Neurocirurgia/organização & administração , Prática Profissional/organização & administração , Espanha/epidemiologia , Doadores de Tecidos/provisão & distribuição , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Índices de Gravidade do Trauma
8.
Am J Transplant ; 12(9): 2498-506, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22682056

RESUMO

A benchmarking approach was developed in Spain to identify and spread critical success factors in the process of donation after brain death. This paper describes the methodology to identify the best performer hospitals in the period 2003-2007 with 106 hospitals throughout the country participating in the project. The process of donation after brain death was structured into three phases: referral of possible donors after brain death (DBD) to critical care units (CCUs) from outside units, management of possible DBDs within the CCUs and obtaining consent for organ donation. Indicators to assess performance in each phase were constructed and the factors influencing these indicators were studied to ensure that comparable groups of hospitals could be established. Availability of neurosurgery and CCU resources had a positive impact on the referral of possible DBDs to CCUs and those hospitals with fewer annual potential DBDs more frequently achieved 100% consent rates. Hospitals were grouped into each subprocess according to influencing factors. Hospitals with the best results were identified for each phase and hospital group. The subsequent study of their practices will lead to the identification of critical factors for success, which implemented in an adapted way should fortunately lead to increasing organ availability.


Assuntos
Benchmarking , Morte Encefálica , Hospitais/normas , Obtenção de Tecidos e Órgãos , Humanos
9.
Am J Transplant ; 12(9): 2507-13, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22703439

RESUMO

The Spanish Quality Assurance Program applied to the process of donation after brain death entails an internal stage consisting of a continuous clinical chart review of deaths in critical care units (CCUs) performed by transplant coordinators and periodical external audits to selected centers. This paper describes the methodology and provides the most relevant results of this program, with information analyzed from 206,345 CCU deaths. According to the internal audit, 2.3% of hospital deaths and 12.4% of CCU deaths in Spain yield potential donors (clinical criteria consistent with brain death). Out of the potential donors, 54.6% become actual donors, 26% are lost due to medical unsuitability, 13.3% due to refusals to donation, 3.1% due to maintenance problems and 3% due to other reasons. Although the national pool of potential donors after brain death has progressively decreased from 65.2 per million population (pmp) in 2001 to 49 pmp in 2010, the number of actual donors after brain death has remained at about 30 pmp. External audits reveal that the number of actual donors could be 21.6% higher if all potential donors were identified and preventable losses avoided. We encourage other countries to develop similar comprehensive approaches to deceased donation performance.


Assuntos
Garantia da Qualidade dos Cuidados de Saúde , Obtenção de Tecidos e Órgãos , Humanos , Espanha
10.
Transplant Proc ; 43(9): 3533-4, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22099835

RESUMO

The initial experience in facial composite tissue allotransplantation has demonstrated that it is surgically feasible, safe, and reproducible. A robust team approach is necessary to warrant successful outcomes. We designed a specific face organ donation that limits facial donation requests followed by synchronous in situ dissection with the internal organs that has proved to be efficient and safe for face and solid organ procurement and transplantation. The first human full face transplantation in our institution was performed on March 27, 2010. The holistic team approach of donation and procurement proved to be effective and reproducible; the recipient showed excellent outcomes at 12 months.


Assuntos
Face/cirurgia , Transplante de Face/métodos , Doadores de Tecidos , Obtenção de Tecidos e Órgãos/métodos , Humanos , Masculino , Seleção de Pacientes , Desenvolvimento de Programas , Espanha , Transplante Homólogo/métodos , Resultado do Tratamento
11.
Med. intensiva (Madr., Ed. impr.) ; 34(8): 534-549, nov. 2010. tab
Artigo em Espanhol | IBECS | ID: ibc-95151

RESUMO

La Resucitación Cardiopulmonar (RCP) se debe aplicar si está indicada, omitirse si no está o no ha sido previamente aceptada por el paciente y suspenderse si es inefectiva. Si la RCP se previera fútil, se registrará una Orden de No Intentar la Resucitación, que deberá ser conocida por los profesionales sanitarios que atienden al enfermo. Es aceptable limitar el soporte vital a los supervivientes con encefalopatía anóxica, si se descarta la posibilidad de que evolucionen a muerte encefálica. Tras la RCP se debe informar y apoyar a la familia del paciente, y revisar el procedimiento realizado para mejorarlo. Previa limitación del soporte vital se podría plantear cierto tipo de donación de órganos a corazón parado. Adquirir competencia en RCP precisa practicar con simuladores y, en ocasiones, sobre cadáveres recientes, siempre con permiso. La investigación sobre RCP es imprescindible, respetando leyes y normas éticas de excelencia (AU)


Cardiopulmonary Resuscitation (CPR) must be attempted if indicated, not done if it is not indicated or if the patient does not accept or has previously rejected it and withdrawn it if it is ineffective. If CPR is considered futile, a Do-Not-Resuscitate Order (DNR) will be recorded. This should be made known to all physicians and nurses involved in patient care. It may be appropriate to limit life-sustaining-treatments for patients with severe anoxic encephalopathy, if the possibility of clinical evolution to brain death is ruled out. After CPR it is necessary to inform and support families and then review the process in order to make future improvements. After limitation of vital support, certain type of non-heart-beating-organ donation can be proposed. In order to acquire CPR skills, it is necessary to practice with simulators and, sometimes, with recently deceased, always with the consent of the family. Research on CPR is essential and must be conducted according to ethical rules and legal frameworks (AU)


Assuntos
Humanos , Reanimação Cardiopulmonar/ética , Parada Cardíaca/terapia , Suporte Vital Cardíaco Avançado/ética , Ordens quanto à Conduta (Ética Médica)/ética , Doadores de Tecidos/ética
12.
Med Intensiva ; 34(8): 534-49, 2010 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-20542599

RESUMO

Cardiopulmonary Resuscitation (CPR) must be attempted if indicated, not done if it is not indicated or if the patient does not accept or has previously rejected it and withdrawn it if it is ineffective. If CPR is considered futile, a Do-Not-Resuscitate Order (DNR) will be recorded. This should be made known to all physicians and nurses involved in patient care. It may be appropriate to limit life-sustaining-treatments for patients with severe anoxic encephalopathy, if the possibility of clinical evolution to brain death is ruled out. After CPR it is necessary to inform and support families and then review the process in order to make future improvements. After limitation of vital support, certain type of non-heart-beating-organ donation can be proposed. In order to acquire CPR skills, it is necessary to practice with simulators and, sometimes, with recently deceased, always with the consent of the family. Research on CPR is essential and must be conducted according to ethical rules and legal frameworks.


Assuntos
Reanimação Cardiopulmonar/ética , Assistência ao Convalescente , Reanimação Cardiopulmonar/educação , Tomada de Decisões/ética , Eutanásia Passiva , Família , Controle de Formulários e Registros , Humanos , Hipóxia Encefálica/terapia , Futilidade Médica , Prontuários Médicos , Relações Profissional-Família , Pesquisa , Ordens quanto à Conduta (Ética Médica) , Espanha , Consentimento do Representante Legal , Coleta de Tecidos e Órgãos/ética , Coleta de Tecidos e Órgãos/legislação & jurisprudência , Suspensão de Tratamento
13.
Transplant Proc ; 41(6): 2265-7, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19715893

RESUMO

INTRODUCTION AND AIMS: It has been described that patients who receive a transplant display a better Health Related Quality of Life (HRQoL). Our objective was to describe the HRQoL before and after a solid organ transplantation, comparing results among various transplantations. METHODS: This HRQoL study using the SF-36 was implemented before as well as at 3 and 12 months posttransplantation. Posttransplantation were compared with pretransplantation scores as well as with the general population. RESULTS: One hundred sixty-two renal, 159 liver, and 58 lung candidates were included before transplantation, among whom there were 126 renal, 108 liver, and 22 lung recipients. The median age of all transplant recipients was 53 years with 68% men. The various transplant types began with different HRQoL: lung showed the worst, followed by the liver, and then renal. The scores of the SF-36 before and 3 months posttransplantation showed significant improvements, except for "Pair." At 12 versus 3 months, mental health was somewhat better for renal, and almost all dimensions showed significant improvement for liver and lung patients. All subjects showed clear improvements after transplantation. CONCLUSION: All patients showed clear improvements after transplantation when mental health was compared with the general population, particularly lung transplant recipients who expressed the greatest improvement. However, they still showed deficits in physical health.


Assuntos
Nível de Saúde , Transplante de Rim/fisiologia , Transplante de Fígado/fisiologia , Transplante de Pulmão/fisiologia , Qualidade de Vida , Feminino , Humanos , Transplante de Rim/psicologia , Transplante de Fígado/psicologia , Transplante de Pulmão/psicologia , Masculino , Saúde Mental , Pessoa de Meia-Idade , Período Pós-Operatório , Estudos Prospectivos , Espanha , Fatores de Tempo
14.
Transplant Proc ; 37(9): 3641-2, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16386490

RESUMO

We believe that it is important to spread information about the organ and tissue transplant-donation (T-D) process to obtain the participation of all society. We prepared an information program about the T-D process for secondary school students in collaboration with the Education Department. We chose these students because they wish to receive information about life and are already conscious about its possible loss, and because they take risks practicing sports or driving cars. We spoke about the frequency of the T-D process in our hospitals, the organs and tissues that can be transplanted the number of people on the waiting list, as well as the origin and circumstances of potential donors. During the last 3 years we have done more than 200 lessons at 44 secondary schools. We consider our experience to be pleasant and useful. Students have accepted us and 96.5% of them have recommended the T-D lessons to future classmates.


Assuntos
Educação em Saúde , Estudantes , Doadores de Tecidos , Transplante , Adolescente , Humanos , Instituições Acadêmicas , Espanha
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