RESUMO
Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The aim of this study was to investigate whether or not there is a natural diurnal fluctuation during daytime in healthy and schizophrenic subjects with a normal light/dark cycle. In a sample of 33 subjects (10 male schizophrenics and 23 healthy subjects) an ELISA assay was used to study the ultradian NGF cycle in blood samples at 9.00, 13.00 and 20.00 hours. The study showed an ultradian rhythm of NGF in healthy subjects with a "V" trend: higher at 9:00 and 20:00 and lower at 13:00. We also show significant differences between male and female controls. No NGF ultradian rhythm among schizophrenic patients compared to healthy subjects was found. The results of this study lead to a rhythmic NGF regulation that appears altered in schizophrenics, where higher levels in the morning and lower levels in the evening were observed, compared to the controls, and support the hypothesis of a role played by NGF in schizophrenia.
Assuntos
Ciclos de Atividade/fisiologia , Fator de Crescimento Neural/sangue , Esquizofrenia/sangue , Adulto , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Escalas de Graduação Psiquiátrica , Valores de Referência , Caracteres Sexuais , Luz SolarRESUMO
The cytologic features of primary and metastatic uterine sarcomas, as seen in both gynecologic and nongynecologic smears from a series of 58 patients with positive cytologic findings, are presented and discussed. Cytologic examination plays a role in tumor typing but not in early diagnosis of uterine sarcomas since these neoplasms almost exclusively originate submucosally and infrequently shed cells prior to attaining considerable size. Cytomorphology of neoplastic cells varied greatly according to the type of tumor and ranged from small, uniform cells in tight, cohesive clusters to bizarre, pleomorphic spindle-shaped cells with long, ill-defined cytoplasmic processes. Distant metastases occurred within an average of 7 months after tissue diagnosis, and the average survival time was 21 months.
