RESUMO
Multiple clinical and laboratory evaluations, including morning plasma cortisol levels, were done in forty patients having moderate to severe psoriasis vulgaris prior to and during treatment with either betamethasone dipropionate in optimized vehicle or clobetasol-17-propionate ointment. The study was randomized, double-blind, and of parallel group design, lasting 3 weeks. Both drugs were effective (3 of 4 achieving at least 75% or more improvement). Temporary reversible suppression of the hypothalamic-pituitary-adrenal axis, as reflected by low morning plasma cortisol determinations, was found in eight of forty patients (20%). The clinician should respect the potential for superpotent topical steroids to cause laboratory evidence of adrenal suppression.
Assuntos
Glândulas Suprarrenais/fisiopatologia , Betametasona/análogos & derivados , Clobetasol/análogos & derivados , Psoríase/tratamento farmacológico , Administração Tópica , Adolescente , Glândulas Suprarrenais/efeitos dos fármacos , Adulto , Idoso , Betametasona/administração & dosagem , Betametasona/efeitos adversos , Betametasona/uso terapêutico , Ensaios Clínicos como Assunto , Clobetasol/administração & dosagem , Clobetasol/efeitos adversos , Clobetasol/uso terapêutico , Método Duplo-Cego , Feminino , Humanos , Hidrocortisona/sangue , Masculino , Pessoa de Meia-Idade , Psoríase/sangue , Psoríase/fisiopatologia , Distribuição AleatóriaRESUMO
The relation between serum cholesterol and cancer incidence was investigated in the population of the Hypertension Detection and Follow-up Program. During the 5 years of follow-up, 286 new cancer cases were documented among the 10,940 participants. Overall, age-adjusted cancer incidence rates, computed by baseline serum cholesterol quartiles, showed a small, but statistically significant, inverse relation between serum cholesterol and cancer incidence. No evidence suggested that the observed relationship was primarily due to confounding by other cancer risk factors, association of low serum cholesterol with incipient but undiagnosed cancer, or problems of competing risks. However, the relationship is weak and a causal interpretation of these immediate results cannot be argued persuasively. Examinations of specific cancer sites and factors related to serum cholesterol are suggested as important lines of research toward clarification of the complex relationships observed.
Assuntos
Colesterol/sangue , Hipertensão/complicações , Neoplasias/complicações , Adulto , Idoso , Peso Corporal , Feminino , Seguimentos , Humanos , Hipertensão/prevenção & controle , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Neoplasias/sangue , Neoplasias/epidemiologia , Probabilidade , Grupos Raciais , Fatores Sexuais , Fumar , Estados UnidosRESUMO
Guidelines for employment and placement of the diabetic in industry have been updated. These guideline are intended to help the physician in his recommendations to management for hiring and job placement so that a safe work environment is insured for both the diabetic and the non-diabetic.
