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1.
J Perinatol ; 44(3): 360-365, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37580511

RESUMO

BACKGROUND: Pregnancies with prenatally diagnosed congenital heart disease (CHD) have increased cesarean delivery (CD) rates, with no outcome improvement. OBJECTIVE: We aim to examine indications for delivery, indications for CD and risk factors associated with CD. STUDY DESIGN: Retrospective cohort of 322 singleton pregnancies prenatally diagnosed with moderate to severe CHD. We compared maternal and fetal factors correlated with delivery route. RESULTS: CD rate was 46% (95% CI 40, 51%). Of all CD, 31.3% (95% CI 23.8, 38.7) were secondary to urgent fetal indications. However, 79.7% of inductions resulted in vaginal delivery (VD). Factors associated with CD include morbid obesity (RR 3.0, 95% CI 1.5, 6.1), diabetes (RR 3.9, 95% CI 2.0, 7.3) and severe pre-eclampsia (6.0, 95% CI 1.7, 21.4). Of the 10 most frequent CHD diagnoses, only hypoplastic-left-heart was associated with CD (OR 1.9, 95% CI 1.02, 3.4). CONCLUSIONS: Although the CD rate is higher in fetal CHD, most indications for CD are maternal.


Assuntos
Doenças Fetais , Cardiopatias Congênitas , Gravidez , Recém-Nascido , Feminino , Humanos , Estudos Retrospectivos , Cesárea/efeitos adversos , Parto Obstétrico/métodos , Cardiopatias Congênitas/diagnóstico por imagem , Cardiopatias Congênitas/etiologia , Doenças Fetais/etiologia
2.
Obstet Gynecol ; 140(6): 965-973, 2022 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-36357989

RESUMO

OBJECTIVE: To describe the pregnancy outcomes of patients who experienced previable and periviable prelabor rupture of membranes (PROM) after the treatment of twin-twin transfusion syndrome. METHODS: We conducted a retrospective cohort study of patients whose pregnancies were complicated by twin-twin transfusion syndrome who were treated with fetoscopic laser photocoagulation at a single fetal center and subsequently experienced PROM from April 2010 to June 2019. Outcomes were infant survival and latency from PROM to delivery. Patients were grouped by gestational age at PROM (before 26 weeks of gestation and 26 weeks or later). The group with PROM before 26 weeks of gestation was stratified by gestational age at PROM for further description of outcomes. RESULTS: Two-hundred fifty of 653 patients (38%) developed PROM, 81 before 26 weeks of gestation and 169 after 26 weeks of gestation. In the setting of PROM before 26 weeks of gestation, the rate of survival of both twins to neonatal intensive care unit (NICU) discharge was 46.3%, compared with 76.9% in the setting of PROM at 26 weeks of gestation or later ( P <.001); the survival rate of at least one twin was 61.2% and 98.5%, respectively ( P <.001). Fourteen, 22, and 45 patients experienced PROM at 16-19 6/7, 20-22 6/7, and 23-25 6/7 weeks of gestation, respectively. Survival of both twins and at least one twin to NICU discharge was 25.0%, 47.4%, 52.8% (for two) and 33.3%, 47.4%, and 77.8% (for at least one), respectively, among those groups. Fifty-seven of the 81 patients with PROM before 26 weeks of gestation experienced a latency longer than 48 hours. In the setting of PROM before 26 weeks of gestation, when latency lasted longer than 48 hours, overall survival was improved (69.6% vs 53.7%, respectively, P =.017). With latency longer than 48 hours and PROM at 16-19 6/7, 20-22 6/7, and 23-25 6/7 weeks of gestation, survival of both twins to NICU discharge was 60.0%, 61.5%, and 60.7%, respectively, and survival of at least one twin was 80.0%, 61.5%, and 85.7%, respectively. CONCLUSION: Earlier gestational age at PROM after laser photocoagulation is associated with longer latency but lower rates of survival. When PROM occurs before 26 weeks of gestation and latency exceeds 48 hours, rates of neonatal survival are significantly improved.


Assuntos
Ruptura Prematura de Membranas Fetais , Transfusão Feto-Fetal , Gravidez , Recém-Nascido , Lactente , Feminino , Humanos , Transfusão Feto-Fetal/cirurgia , Resultado da Gravidez , Ruptura Prematura de Membranas Fetais/terapia , Estudos Retrospectivos , Fetoscopia/efeitos adversos , Idade Gestacional , Fotocoagulação/efeitos adversos , Lasers , Gravidez de Gêmeos
3.
J Matern Fetal Neonatal Med ; 35(16): 3114-3118, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32862742

RESUMO

BACKGROUND: Preterm birth contributes to over one-third of infant deaths, and although there are several risk factors for preterm birth few tests predict this obstetric complication. Midtrimester transvaginal cervical length (TVCL) screening is currently the best clinical predictor of spontaneous preterm birth and has been suggested to be applied universally. Although several studies have examined the cost-efficacy of universal screening, the time consumption and resultant time management has not been examined. OBJECTIVE: We aim to quantitate the time requirement for transvaginal cervical length (TVCL) screening with the implementation of universal TVCL screening.Study design: This is a retrospective cohort study of women undergoing cervical length screening after implementation of universal Transvaginal Cervical Length (TVCL) screening at a university setting over a 1-year period. The primary outcome was time in minutes for TVCL screening from completion of transabdominal to completion of transvaginal ultrasound. RESULTS: This study included 2803 ultrasounds, 1673 of which involved completion of a TVCL after completion of abdominal imaging between 16 0/7 and 23 6/7 weeks of gestation. The mean duration of cervical length screening was 9.8 min (standard deviation [SD], 4.0 min). The time range was less than 1 min to 48 min. For women obtaining cervical lengths, 4.2% required less than 5 additional minutes to perform cervical length screening, 52.1% (872), required less than 10 additional minutes. The majority, 91.8%, of ultrasounds required less than 15 min to complete. Ultrasounds performed in private practice sites required less time compared to those at teaching sites (8.2 ± 3.1 min versus 10.2 ± 4.1 min, p < .001). No significant time improvement occurred after 6 months of universal TVCL screening, with the first 6 months average of 10.1 min versus 9.6 min in the later half, p = .61. CONCLUSION: Implementation of a universal TVCL program adds an average of 10 min to each ultrasound exam. This additional time does diminish with increasing experience with TVCL, but not to a significant degree.


Assuntos
Medida do Comprimento Cervical , Nascimento Prematuro , Medida do Comprimento Cervical/métodos , Colo do Útero/diagnóstico por imagem , Feminino , Humanos , Recém-Nascido , Gravidez , Segundo Trimestre da Gravidez , Nascimento Prematuro/diagnóstico , Nascimento Prematuro/prevenção & controle , Estudos Retrospectivos
4.
Am J Obstet Gynecol MFM ; 3(1): 100255, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33451594

RESUMO

BACKGROUND: Universal transvaginal cervical length screening has been increasingly implemented with both positive and negative consequences. OBJECTIVE: In this study, we described the diagnostic incidence of low-lying placenta and placenta previa with the implementation of universal transvaginal cervical length screening. STUDY DESIGN: This is a retrospective cohort study of women undergoing midtrimester universal transvaginal cervical length screening. The primary outcome was the rate of transvaginal diagnosis of low-lying placenta or placenta previa using midtrimester universal transvaginal cervical length screening. RESULTS: This study included 1982 midtrimester ultrasounds, of which 211 indicated a low-lying placenta or placenta previa on either transabdominal or transvaginal ultrasound. With transvaginal ultrasound, a low-lying placenta or placenta previa was diagnosed in 211 women (10.6% of the study population). Of the 211 patients with a low-lying placenta or placenta previa, 90 (42.6%) had a false-negative result, diagnosed using only transvaginal ultrasound; 112 (53.1%) had a true-positive result; and 9 (4.3%) had a false-positive result. The relative risk of having an abnormal finding on ultrasound with the addition of universal transvaginal cervical length screening was 9.2 (95% confidence interval, 4.6-18.1). Of the low-lying placenta or placenta previa diagnosed using midtrimester universal transvaginal cervical length screening, 98.9% resolved (95% confidence interval, 93.7-99.97). CONCLUSION: Implementation of universal transvaginal cervical length screening increases the diagnostic incidence of low-lying placenta or placenta previa without an increase in the diagnoses that persist to term, which comes at the cost of increased follow-up ultrasounds and potentially increased anxiety for the patient.


Assuntos
Placenta Prévia , Feminino , Humanos , Incidência , Placenta/diagnóstico por imagem , Placenta Prévia/diagnóstico , Gravidez , Estudos Retrospectivos , Ultrassonografia Pré-Natal
5.
J Matern Fetal Neonatal Med ; 32(22): 3841-3846, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29739262

RESUMO

Objective: The objective of this study is to determine whether cervical ripening with misoprostol (MP) is associated with higher rates of cesarean delivery (CD) compared with dinoprostone (DP) or Pitocin/Foley balloon (PFB) in infants found to be small for gestational age (SGA). Study design: Single center institution based cohort study of all inductions between 2008 and 2012 where birth weight was found to be as SGA (< 10th percentile). Maternal demographic, obstetric, and labor characteristics were compared between SGA births where cervical ripening with MP, DP, or PFB was used as the primary agent. The primary outcome was CD after attempted induction between the three study groups which included MP, DP, and PFB. Secondary outcomes included inability to achieve active labor (defined as cervical dilation of 6 cm or greater), cervical dilation at the time of CD, the incidence of CD for the indication of non-reassuring fetal status, and neonatal outcomes including Apgar scores and admission to neonatal intensive care unit. Multivariable logistic regression was performed to evaluate the association of these outcomes with MP as the induction agent versus the referent groups, PFB. Results: Of 260 inductions where the infant was found to be SGA by birth weight during the 5-year period, 172 (66.2%) patients were induced using MP, 38 (14.6%) with DP, and 50 (19.2%) with PFB. There were no differences in baseline characteristics between groups (age, race, BMI, parity, induction indication, birth weights, or maternal comorbidities). MP did not increase rate of CD which was 25.6%, 26.3%, and 22.0% in the MP, DP, and PFB groups, respectively (p = .86). There were also no differences in incidence of CD for non-reassuring fetal well-being (NRFWB), failure to attain active labor, or cervical dilation at time of CD between induction groups. NICU admission was 18%, 18%, and 16% (p = .94) between MP, DP, and PFB groups, respectively. MP was not associated with an increased rate of CD when compared with the other two agents combined, aOR 0.93 (0.67-1.30, 95% CI). Conclusion: MP appears to have similar efficacy and safety when compared with other cervical ripening agents in pregnancies complicated by SGA.


Assuntos
Maturidade Cervical , Trabalho de Parto Induzido/métodos , Prostaglandinas/uso terapêutico , Cateterismo Urinário , Adolescente , Adulto , Maturidade Cervical/efeitos dos fármacos , Maturidade Cervical/fisiologia , Estudos de Coortes , Dinoprostona/uso terapêutico , Feminino , Humanos , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional , Misoprostol/uso terapêutico , Ocitócicos/uso terapêutico , Gravidez , Resultado da Gravidez , Resultado do Tratamento , Adulto Jovem
6.
J Hosp Med ; 14(1): 9-15, 2019 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-30534642

RESUMO

BACKGROUND: Hospitals are complex adaptive systems within which multiple components such as patients, practitioners, facilities, and technology interact. A careful approach to optimization of this complex system is needed because any change can result in unexpected deleterious effects. One such approach is discrete event simulation, in which what-if scenarios allow researchers to predict the impact of a proposed change on the system. However, studies illustrating the application of simulation in optimization of general internal medicine (GIM) team inpatient operations are lacking. METHODS: Administrative data about admissions and discharges, data from a time-motion study, and expert opinion on workflow were used to construct the simulation model. Then, the impact of four changes: aligning medical teams with nursing units, adding a hospitalist team, adding a nursing unit, and adding both a nursing unit and hospitalist team with higher admission volume were modeled on key hospital operational metrics. RESULTS: Aligning medical teams with nursing units improved team metrics for aligned teams but shifted patients to unaligned teams. Adding a hospitalist team had little benefit, but adding a nursing unit improved system metrics. Both adding a hospitalist team and a nursing unit would be required to maintain operational metrics with increased patient volume. CONCLUSION: Using simulation modeling, we provided data on the implications of four possible strategic changes on GIM inpatient units, providers, and patient throughput. Such analyses may be a worthwhile investment to study strategic decisions and make better choices with fewer unintended consequences.


Assuntos
Simulação por Computador , Previsões , Medicina Interna , Eficiência Organizacional , Feminino , Médicos Hospitalares/estatística & dados numéricos , Hospitais/estatística & dados numéricos , Humanos , Masculino , Admissão do Paciente/estatística & dados numéricos , Equipe de Assistência ao Paciente/estatística & dados numéricos , Alta do Paciente/estatística & dados numéricos , Estudos de Tempo e Movimento
7.
Am J Perinatol ; 35(14): 1423-1428, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29920640

RESUMO

OBJECTIVE: We aim to quantify the impact of obesity on maternal intensive care unit (ICU) admission. MATERIALS AND METHODS: This is a population-based, retrospective cohort study of Ohio live births from 2006 to 2012. The primary outcome was maternal ICU admission. The primary exposure was maternal body mass index (BMI). Relative risk (RR) of ICU admission was calculated by BMI category. Multivariate logistic regression quantified the risk of obesity on ICU admission after adjustment for coexisting factors. RESULTS: This study includes 999,437 births, with peripartum maternal ICU admission rate of 1.10 per 1,000. ICU admission rate for BMI 30 to 39.9 kg/m2 was 1.24 per 1,000, RR: 1.20 (95% confidence interval [CI]: 1.07, 1.35); BMI 40 to 49.9 kg/m2 had ICU admission rate of 1.80 per 1,000, RR: 1.73 (95% CI: 1.38, 2.17); and BMI ≥ 50 kg/m2 had ICU admission rate of 2.98 per 1,000, RR: 1.73 (95% CI: 1.77, 4.68). After adjustment, these increases persisted in women with BMI 40 to 49.9 kg/m2 with adjusted relative risk (adjRR) of 1.37 (95% CI: 1.05, 1.78) and in women with BMI ≥ 50 kg/m2, adjRR: 1.69 (95% CI: 1.01, 2.83). CONCLUSION: Obesity is a risk factor for maternal ICU admission. Risk increases with BMI. After adjustment, BMI ≥ 40 kg/m2 is an independent risk factor for ICU admission.


Assuntos
Unidades de Terapia Intensiva , Obesidade/complicações , Admissão do Paciente/estatística & dados numéricos , Complicações na Gravidez/epidemiologia , Adolescente , Adulto , Índice de Massa Corporal , Cesárea , Feminino , Humanos , Modelos Logísticos , Análise Multivariada , Ohio/epidemiologia , Gravidez , Cuidado Pré-Natal , Sistema de Registros , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
8.
JAMA ; 318(11): 1026-1034, 2017 09 19.
Artigo em Inglês | MEDLINE | ID: mdl-28975304

RESUMO

Importance: The rate of obesity among US women has been increasing, and obesity is associated with increased risk of surgical site infection (SSI) following cesarean delivery. The optimal perioperative antibiotic prophylactic regimen in this high-risk population undergoing cesarean delivery is unknown. Objective: To determine rates of SSI among obese women who receive prophylactic oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery. Design, Setting, and Participants: Randomized, double-blind clinical trial comparing oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery for the prevention of SSI in obese women (prepregnancy BMI ≥30) who had received standard intravenous preoperative cephalosporin prophylaxis. Randomization was stratified by intact vs rupture of membranes prior to delivery. The study was conducted at the University of Cincinnati Medical Center, Cincinnati, Ohio, an academic and urban setting, between October 2010 and December 2015, with final follow-up through February 2016. Interventions: Participants were randomly assigned to receive oral cephalexin, 500 mg, and metronidazole, 500 mg (n = 202 participants), vs identical-appearing placebo (n = 201 participants) every 8 hours for a total of 48 hours following cesarean delivery. Main Outcomes and Measures: The primary outcome was SSI, defined as any superficial incisional, deep incisional, or organ/space infections within 30 days after cesarean delivery. Results: Among 403 randomized participants who were included (mean age, 28 [SD, 6] years; mean BMI, 39.7 [SD, 7.8]), 382 (94.6%) completed the trial. The overall rate of SSI was 10.9% (95% CI, 7.9%-14.0%). Surgical site infection was diagnosed in 13 women (6.4%) in the cephalexin-metronidazole group vs 31 women (15.4%) in the placebo group (difference, 9.0% [95% CI, 2.9%-15.0%]; relative risk, 0.41 [95% CI, 0.22-0.77]; P = .01). There were no serious adverse events, including allergic reaction, reported in either the antibiotic group or the placebo group. Conclusions and Relevance: Among obese women undergoing cesarean delivery who received the standard preoperative cephalosporin prophylaxis, a postoperative 48-hour course of oral cephalexin and metronidazole, compared with placebo, reduced the rate of SSI within 30 days after delivery. For prevention of SSI among obese women after cesarean delivery, prophylactic oral cephalexin and metronidazole may be warranted. Trial Registration: clinicaltrials.gov Identifier: NCT01194115.


Assuntos
Antibacterianos/uso terapêutico , Antibioticoprofilaxia , Cefalexina/uso terapêutico , Cesárea/efeitos adversos , Obesidade/complicações , Infecção da Ferida Cirúrgica/prevenção & controle , Administração Oral , Adulto , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Humanos , Metronidazol/uso terapêutico , Cuidados Pós-Operatórios
9.
J Ultrasound Med ; 34(5): 837-42, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25911717

RESUMO

OBJECTIVES: To evaluate the growth rate in fetuses with suspected growth restriction according to their Doppler characteristics. METHODS: A retrospective cohort of fetuses with suspected growth restriction was identified. We reviewed umbilical artery and middle cerebral Doppler pulsatility indices and calculated the cerebroplacental ratio. Three study groups were determined: (1) normal umbilical artery Doppler findings; (2) abnormal umbilical artery findings with a normal cerebroplacental ratio; and (3) abnormal umbilical artery findings with an abnormal cerebroplacental ratio. The primary outcome was the growth rate as estimated by fetal biometry from serial sonographic evaluations. Analysis of the mean growth rate in each study group was performed by analysis of variance. In addition, linear regression analysis comparing the cerebroplacental ratio to the growth rate was performed. RESULTS: Fetal growth restriction was suspected in 416 patients; 176 patients were included in this analysis: 113, 38, and 25 in groups 1, 2, and 3 respectively. The estimated mean (SD) growth rate in group 3 was significantly lower than in groups 1 and 2: 8.3 (4.4) versus 19.6 (6.0) and 18.6 (7.7) g/d, respectively (P < .001). Linear regression analysis revealed a strong correlation between the growth rate and cerebroplacental ratio (r = 0.76; R(2) = 0.58) as well as the birth weight and cerebroplacental ratio (r = 0.78; R(2) = 0.61). CONCLUSIONS: In fetuses with suspected growth restriction and abnormal umbilical artery Doppler findings, an abnormal cerebroplacental ratio is strongly associated with reduced fetal growth. In contrast, if the cerebroplacental ratio is normal, even in the setting of abnormal umbilical artery Doppler findings, fetuses grow similarly to those with normal umbilical artery findings.


Assuntos
Artérias Cerebrais/diagnóstico por imagem , Ecocardiografia Doppler/métodos , Retardo do Crescimento Fetal/diagnóstico por imagem , Interpretação de Imagem Assistida por Computador/métodos , Ultrassonografia Pré-Natal/métodos , Artérias Umbilicais/diagnóstico por imagem , Algoritmos , Artérias Cerebrais/embriologia , Feminino , Humanos , Aumento da Imagem/métodos , Masculino , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Artérias Umbilicais/embriologia
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