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Colloids Surf B Biointerfaces ; 139: 95-9, 2016 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-26700238

RESUMO

A polymer film composed of a mixture of chitosan (Ch) and carboxymethyl cellulose sodium salt (CMC) nanofibers was deposited on a glass surface. The thin film of the Ch-CMC mixture obtained was stable, and fibroblast adhesion to the film was lowest when the weight ratio of Ch to CMC was 4:6. The ζ-potential and contact angle of the mixture film indicated that a polyion complex of Ch and CMC was formed. The mechanical strength of the film composed of Ch-CMC nanofiber complexes was much higher than that of the film composed of Ch-water-soluble CMC complexes (non-nanofiber), likely because the entanglement of nanofibers was enhanced by electrostatic attractions. These results indicate that the charge-neutralized nanofiber film was highly effective in suppressing cell adhesion and therefore is a promising material for biomedical applications.


Assuntos
Carboximetilcelulose Sódica/farmacologia , Quitosana/farmacologia , Nanofibras/química , Animais , Carboximetilcelulose Sódica/química , Adesão Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Quitosana/química , Camundongos , Células NIH 3T3 , Eletricidade Estática , Propriedades de Superfície , Resistência à Tração/efeitos dos fármacos
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