RESUMO
PURPOSE: To compare the efficiency and ocular side-effect profile of topical loteprednol applied to one eye and topical dexamethasone applied to the other eye in the early period on the same patient who has subepithelial infiltrates (SEI). METHODS: The patients who developed bilateral SEI following epidemic keratoconjunctivitis (EKC) were applied topical loteprednol on one eye (group 2) and topical dexamethasone on the other (group 1). RESULTS: Decrease in the symptoms was faster in the dexamethasone group, but this difference between the groups was not statistically significant (p = 0.073). Both groups were found to have substantial recurrence. However, the difference between the groups was not statistically significant (p = 0.131). CONCLUSIONS: The study has found that in the treatment of SEI, which developed after EKC, statistically similar results can be obtained with loteprednol, which is known to have fewer adverse effects.
Assuntos
Infecções por Adenovirus Humanos/tratamento farmacológico , Antialérgicos/uso terapêutico , Conjuntivite Viral/tratamento farmacológico , Doenças da Córnea/tratamento farmacológico , Dexametasona/uso terapêutico , Epitélio Corneano/efeitos dos fármacos , Glucocorticoides/uso terapêutico , Etabonato de Loteprednol/uso terapêutico , Administração Oftálmica , Adolescente , Adulto , Antialérgicos/efeitos adversos , Criança , Doenças da Córnea/etiologia , Substância Própria/efeitos dos fármacos , Substância Própria/patologia , Dexametasona/efeitos adversos , Epitélio Corneano/patologia , Infecções Oculares Virais/tratamento farmacológico , Feminino , Glucocorticoides/efeitos adversos , Humanos , Etabonato de Loteprednol/efeitos adversos , Masculino , Pessoa de Meia-Idade , Soluções Oftálmicas , Estudos Prospectivos , Resultado do Tratamento , Acuidade Visual/fisiologia , Adulto JovemRESUMO
PURPOSE: Genetic factors are shown to have a role in the development of primary open-angle glaucoma (POAG). The aim of this study was to determine the effects of genetic polymorphisms of Rho-kinase (ROCK) genes on the risk of POAG in a Turkish population. METHODS: Genomic DNA was extracted from leukocytes of the peripheral blood, and 8 single nucleotide polymorphisms in the ROCK1 and ROCK2 genes were analysed in 179 patients with POAG and in 182 healthy controls of similar age by using BioMark HD dynamic array system. RESULTS: Neither genotype distributions nor the allele frequencies for the ROCK1 (rs35996865) and ROCK2 [rs2290156, rs965665, rs10178332, rs2230774 (Thr431Asn), rs2230774 (Thr431Ser), rs6755196, and rs726843] gene polymorphisms showed a significant difference between the groups. There were also no marked associations between the haplotype frequencies and POAG. CONCLUSIONS: This is the first study to examine the involvement of ROCK1 and ROCK2 gene variations in the risk of POAG development. This study demonstrated that the polymorphisms studied are not associated with the increased risk of development of POAG in the Turkish population.
