RESUMO
Ginseng (Panax ginseng) and Ashwagandha (Withania somnifera) are widely used as geriatric tonics. Both individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing subacute toxicity study in rats with 90 days oral administration using three doses. Food consumption, body weight, haematological, biochemical and histopathological parameters were studied. There was significant increase in body weight, food consumption and liver weight, and improved hematopoiesis was observed. Brain, heart, lung, liver, spleen, kidneys, stomach, testis and ovaries were normal on gross examination and histopathologically. Subacute toxicity studies in rats did not reveal any toxicity.
Assuntos
Panax , Extratos Vegetais/toxicidade , Plantas Medicinais , Withania , Administração Oral , Animais , Anti-Inflamatórios não Esteroides/toxicidade , Combinação de Medicamentos , Ingestão de Alimentos/efeitos dos fármacos , Feminino , Hemoglobinas/metabolismo , Fígado/efeitos dos fármacos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Aumento de Peso/efeitos dos fármacosAssuntos
Anfetamina/toxicidade , Eletrochoque , Animais , Masculino , Camundongos , Camundongos EndogâmicosRESUMO
The effect of chronic application of electroconvulsive shocks (ECS) on the time of onset of convulsions and percentage of mice convulsed by the centrally acting drugs picrotoxin and pentylenetetrazol (PTZ) was studied in mice. There was a significant decrease in time to onset of convulsions in the ECS group following PTZ but not after picrotoxin. However, mortality was significantly increased following administration of either drugs after ECS pretreatment. The results support the hypothesis of ECS increasing either postsynaptic sensitivity or neuronal sensitivity.
